All posts by: Sarah Hansen, M.S. '15


UMBC biologists discuss human health applications of studying plants’ circadian rhythms in The Conversation

Humans have been observing the circadian rhythms of plants for millennia, even if they couldn’t fully explain what they saw. In a new piece for The Conversation, Hua Lu, associate professor of biological sciences at UMBC, and Linda Wiratan ’19, biochemistry and molecular biology, survey current knowledge of plants’ daily rhythms and how recent findings could influence human medical care.

“The internal time-sensing mechanism,” known as the circadian clock, “allows many living organisms to keep track of time and coordinate their behaviors along 24-hour cycles,” write Lu and Wiratan. Important advances in circadian clock research led to the 2017 Nobel Prize in physiology or medicine being awarded for work that explained the molecular basis of circadian rhythms.

Lu and Wiratan, among others, are studying plants’ circadian clocks “for insights into how they affect the health and well-being of all life on Earth,” they write. They point out that bacteria, fungi, insects, plants, and mammals are all affected by circadian rhythms, which are regulated by the circadian clock’s central oscillator, “an elaborate network of genes that turn each other’s activity on and off,” forming “complex feedback loops that accurately calibrate time.”

While the exact genes involved differ across organisms, the basic feedback-loop mechanism is the same. “Such amazing balancing acts reflect organisms’ abilities to anticipate changing environment throughout the day,” Lu and Wiratan write, which includes everything from herbivore activity to light availability.

Researchers have found evidence that improper circadian clock function plays a role in human diseases such as diabetes, obesity, and depression, so a fuller understanding of the clock is important for human health. Plants’ circadian clocks also regulate the function of their immune systems. First-line defenses include ever-present physical features like protective hairs and waxy coatings, but plants also have more sophisticated ways of fending off their foes. Some plant cells can detect the presence of pathogens, triggering a cascade of defense responses such as production of antimicrobial compounds.

“Even in the absence of pathogens, many of these responses show low but rhythmic changes that are influenced by the circadian clock,” Lu and Wiratan say. “When a real attack arrives, the plants’ daily rehearsal of their defense systems ensures a strong and concerted timely defense. Plants with misaligned clocks succumb to the attack.” Their clock allows the plants “to time their defense, which allows them to anticipate likely attacks before they occur and modulate defense responses to real attackers.”

For example, Arabidopsis (a small flowering plant ubiquitous in plant science laboratories) peaks its production of jasmonic acid, a hormone associated with the defense response, at noon, to prepare for the predictable onslaught of cabbage looper caterpillar feeding a few hours later. It’s unknown how in-sync pathogen and plant clocks are, but evidence suggests that some pathogens can manipulate the Arabidopsis clock.

These relationships aren’t limited to plants and their pests. “In humans and mice, some populations of gut microbiota oscillate daily, depending on the host circadian clock,” Lu and Wiratan write, adding that “interestingly, gut microbiota are capable of re-programming the host clock […] Research in this area represents a fascinating and unexplored level of host-invader dynamics.”

All of this research on plants has provided a great deal of knowledge about circadian rhythms “and their role in modulating everything from development to defense,” Lu and Wiratan write. “As researchers continue to untangle more about how these clocks work—including how they influence interactions between hosts and their invading pathogens and pests—new forms of specially-timed precision medicine could be on the horizon.”

 

The original article, Studying circadian rhythms in plants and their pathogens might lead to precision medicine for people, has been viewed more than 4,750 times and republished in outlets such as Smithsonian Magazine, World Economic Forum, and at Phys.org.

Image: Floral clock in Edinburgh, Ireland. Photo by Patrick Down, used under CC BY-NC 2.0.

 

Philip Graff ’08 named Outstanding Young Scientist by Maryland Science Center

Throughout his career, Philip Graff ’08, mathematics and physics, has conducted research at Cambridge University on a prestigious Gates Cambridge Scholarship, developed an algorithm that enabled experiments confirming the existence of gravitational waves, and worked to improve cybersecurity measures for the U.S. armed forces and Department of Homeland Security.

This fall, the Maryland Science Center named Graff their 2017 Outstanding Young Scientist – Non-academic Track. At a ceremony held November 15, the center honored two scientists and two engineers, including UMBC’s Lee Blaney, associate professor of chemical, biochemical, and environmental engineering. Researchers younger than 35 in academia and younger than 40 in other sectors who have distinguished themselves with accomplishments in science and engineering are eligible for the awards.

Graff’s research career began at UMBC in the lab of Markos Georganopoulos, associate professor of physics, who noted his potential early on. “Once I gave Philip a suggestion on how to solve a key issue with the stability of our code, but my suggestion was wrong in a subtle way,” Georganopoulos remembers. “Philip found my error by himself, modified my suggestion, and fixed the code in two days.”

Yet, Graff maintained his humility as a new researcher. “When you’re starting out in research, there’s a lot to learn in the beginning,” he says, “and [Georganopoulos] definitely put in the time to help me work through that,” especially pertaining to scientific writing. Graff and Georganopoulos published a paper with Graff as first author—a rare accomplishment for an undergraduate—and Graff presented the findings at an academic conference. The paper dealt with modeling blazars, a variety of quasar that Graff describes as “bright and energetic beams of radiation coming from black holes at the centers of galaxies.”

“As an undergrad, Philip took on and completed a computational astrophysics project that was practically at the level of a heavy Ph.D. thesis,” shared Georganopoulos. “Many astrophysicists at conferences had a hard time believing that the problem we worked on was solved by an undergraduate student.”

Graff’s research experience at UMBC catapulted him to a summer internship at CalTech’s Laser Interferometer Gravitational-Wave Observatory (LIGO) Lab, a leading center for gravitational wave research. After that, he received the Gates Cambridge Scholarship, a younger version of the prestigious Rhodes Scholarship, to pursue a Ph.D. at Cambridge University. Nancy Lloyd Miller ’74, political science, M.P.R. ’85, policy sciences, and the recently-retired associate director of academic and pre-professional advising, provided significant support throughout Graff’s application process, he says.

Graff’s work at Cambridge continued to focus on LIGO, this time developing software tools to analyze data from LIGO and beyond. “We were very focused on making sure any new software we developed for data analysis would be generally applicable,” Graff says, “and that other people would be able to take it and use it to solve their problems as well.”

After completing a Ph.D. in physics at Cambridge, Graff continued his LIGO work at NASA Goddard Space Flight Center in Greenbelt, Maryland. In 2015, he transitioned to the Johns Hopkins Applied Physics Laboratory, where he is working primarily on projects for the U.S. government.

Graff’s years at UMBC, which also included involvement in student government and Greek life, provided the foundation for his success. “UMBC prepared me for the Gates [Scholarship] to get me to Cambridge, and […] set me on the path that I’m on now,” he shares. “It was one of the important steps on the way.”

The award, Graff says, “is a real honor. I hadn’t expected it. Now I just hope I can continue to live up to it, so that I’m not just an outstanding young scientist, but can continue to do good work in the future.”

Undergraduate Research Symposium award winners embody success of UMBC STEM BUILD program

This fall, hundreds of students from across the East Coast gathered to present their research and compete for awards at UMBC’s Undergraduate Research Symposium in the Chemical and Biological Sciences (URS). Fifty-two of the student scientists attend UMBC and participate in a program designed to provide research opportunities to a broad range of students in STEM and boost their confidence, increase the likelihood they pursue STEM graduate degrees, and set them on a path to success.

The program is UMBC STEM Building Infrastructure Leading to Diversity (BUILD).  Eight BUILD students won awards, which is a good sign for the effectiveness of this relative newcomer among UMBC’s cohort programs. UMBC is one of 10 lead institutions on the STEM BUILD initiative nationwide and received $18 million from the National Institutes of Health to launch it in 2014 with the goal to “create a national model of comprehensive support to expand and increase the success of students in STEM.”

“The BUILD participants at URS exemplify the objectives of the program,” says Laura Ott, STEM BUILD active learning coordinator and director of UMBC’s Science Education Research Unit. All BUILD participants complete summer research, either in opportunities they arrange themselves or in small groups on campus organized by the program. BUILD students also receive financial support and extensive academic advising.

STEM BUILD is also a scientific study, so participants’ progress is carefully tracked to try to tease out which supports have the biggest impact on student success. “By participating in the BUILD program, they’re helping us explore novel strategies to increase participation in undergraduate research for all students,” Ott says.

Teodora (“Roxie”) Danaila ’20, biological sciences, Arjun Sharma ’20, biological sciences, and Amber Thompson ’20, biochemistry and molecular biology and mathematics, worked together to characterize antibiotic resistance genes present in local freshwater samples. Their team won second place in their biochemical and molecular biology group at URS. Mohammed Arafat ‘20, psychology; Yasmin Khan ‘20, biological sciences; and Sharanja Mathyvannan ‘20, pre-mechanical engineering, completed a similar project and won second place in their group.

Caitlin Kowalewski ’14, biological sciences, M.S. ’15, applied molecular biology, and now research coordinator for the College of Natural and Mathematical Sciences; Josh Wilhide, M.S. ’10, chemistry, and manager of UMBC’s Molecular Characterization and Analysis Complex; and their assistants, Dave Varisco and Tim Cain ’18, chemistry education, mentored the students in the on-campus, three-week “Summer Bridge” experience.

“Ms. Kowalewski was able to get me to step my game up and allowed me to see what I was capable of,” Arafat shares. “If you ever had questions or were having trouble,” Danaila says, “they were there.” The mentors “allowed us to relay ideas back and forth with people who had much more experience and knowledge than us,” adds Sharma.

Presenting at the symposium had benefits, too. “It allowed me to explore fields of research that may interest me, and also helped me improve my presentation and research methods,” Sharma says. Thompson appreciated the opportunity to speak with students from other schools. “I was interested in how they got into their labs and what it was like for them in a different lab environment,” she shared.

“I felt that my role in mentoring the students was not only to teach them the laboratory skills, but to help them grow as scientists and researchers,” Kowalewski says. She was impressed by their rapid progress in the content-intensive program. “The fact that they were able to understand the information and present it well enough to win an award at URS was a testament to all of their hard work,” she says. Overall, the summer experience under Kowalewski’s tutelage is intended to build the students’ proficiency in a wide range of scientific techniques and prepare them for independent research opportunities.

Temiloluwa Okusolubo ’19, biological sciences, and Ifeoma (“Fefe”) Azinge ’19, biological sciences, are in their second year of BUILD participation and both earned first place in their biochemical and molecular biology groups at URS for independent research. Okusolubo studied the folding of serpin proteins, which are implicated in various diseases related to lung function, at the University of Massachusetts Amherst. Azinge’s research at the National Institute on Aging in Baltimore focused on calcium transport in sweat glands, which is critical for temperature regulation.

Okusolubo and Azinge’s successes are the kind of outcomes that UMBC STEM BUILD hopes to facilitate, using systems that other schools can eventually adopt. Ott is proud of the students in the program, she says, “and I have high hopes for where they’ll go in the future.”

Image: Students and faculty at the 2017 UMBC Undergraduate Research Symposium. Photo by Mohammed Arafat ’20.

20th Undergraduate Research Symposium shines a light on students’ diverse contributions to science

UMBC’s Undergraduate Research Symposium for the Chemical and Biological Sciences has become a destination for young researchers across the Eastern Seaboard, and it’s still growing. This year’s 20th running of the event was the largest yet, with 307 students from 47 institutions presenting 245 distinct research projects to 54 faculty judges, on topics from ecology to molecular biology to inorganic chemistry.

Nearly 100 UMBC students participated in the flagship event, which offers a rare opportunity for undergraduates to gather in large numbers to discuss their work with one another and practice presenting their findings to a wide range of people.

UMBC President Freeman Hrabowski described UMBC’s culture in his morning address, emphasizing the importance of persistence. “Success is about grit—the determination to never never never give up,” he said. “It’s that passion for continuing to learn.”

At UMBC, he continued, which welcomes students from more than 100 countries, “we are interested in making the point to America through you and others that science is exciting, that anyone who is willing to put in the effort can do it, and that you can never ask enough questions.”

Those questions can lead to important answers that impact the lives of others. “The nobility of scientific research is that you work on problems to help people you may never see. Something about that gives me goosebumps,” Hrabowski shared, adding, “What you are doing will save humankind.”

That includes research by students like Emily Bush, from Elmira College in Elmira, New York.  She’s studying the effects of eugenol, an oily substance extractable from various herbs, on cancer cells. The scientist who judged her poster conducts research on the same cell lines, so Bush is heading home armed with useful feedback, inspired to “go back to the lab and really get some results and draw conclusions.”

Myra Dickey, of Salisbury University in Maryland, studied endangered spotted turtles in her research. By examining their DNA, she found that both sexes tend to disperse from their birthplace, which reduces the risk of inbreeding, but populations are so small and isolated that inbreeding’s detrimental effects are still a major concern. That means habitat conservation for the turtles is critical to their long-term survival.

Steven Lawrence and Moises Ridriguez, students at Medgar Evers College in Brooklyn, New York, presented research they conducted through the Research Initiative for Scientific Enhancement (RISE) program at Columbia University and New York University, respectively. Lawrence learned new coding skills to analyze data collected from surveys of Dominican women about their concerns related to HIV. His findings will inform educational programs in Dominica, and he says the experience encouraged him to pursue health outreach activities. Rodriguez studied the relationship between the presence of a molecule called RAGE and the shape of cells in the brain called microglia. His results suggest that RAGE is involved in the inflammatory response, which is part of aging.

Ryan White, associate professor of chemistry and Ohio Eminent Scholar at the University of Cincinnati and former associate professor of chemistry and biochemistry at UMBC, encouraged attendees to recognize the value of their work in his plenary talk. “Undergraduate research projects are not just side projects to give you experience and something to put on your resume,” he said. “Small discoveries you make along the way can really build momentum and lead to something bigger.”

White rebuffed rhetoric in the media suggesting millennials are “lazy” or “hopeless.” “You’re doing research, you’re critically thinking about what you’re doing, you’re solving problems,” he shared. “So my charge to you is to go out there and continue to do that—to prove all these articles wrong.”

White’s interdisciplinary lab is developing a range of bio-inspired sensors, with the broad goal of “building sensors that can help people by providing information to inform personalized medicine,” he said. To do that, he’s employing knowledge and techniques from nanoscience, electrochemistry, and biology—and several undergraduate students.

Dean Bill LaCourse, of the College of Natural and Mathematical Sciences, was also optimistic, and echoed Hrabowski’s sentiments about the value of diversity in science. “When I do my research, I ask questions from the world from which I came,” he shared. “What’s beautiful about a room like this, and all your faces, all your backgrounds, is that the number of problems that can be addressed, the number of questions that can be asked, is multiplied.”

Looking out at the next generation of scientists, he reminded them, “You can answer questions to change the world that you grew up in. You have the power to create the future.”

Image: Students and guests explore the research posters in the University Center Ballroom. Photo by Mohammed Arafat ’19.

UMBC scientists measure plant productivity from space, with applications from farming to forest conservation

Two researchers at UMBC’s Joint Center for Earth Systems Technology (JCET) and colleagues have found that instrumentation on the International Space Station (ISS) can collect data measuring the photosynthetic activity of various ecosystems and landscapes in a way that is both more comprehensive and more nuanced than standard land-based techniques.

“We’re laying the groundwork for developing ways of monitoring vegetation,” says Fred Huemmrich, JCET scientist and lead author on the new study. High-resolution monitoring of photosynthesis on landscapes such as agricultural fields, forests, and grasslands could inform everything from farming practices to our understanding of climate change.

Being able to detect productivity at high resolution could help farmers “evaluate how the field is doing, where there are problems, and perhaps identify things like insect damage and stress responses,” says Huemmrich, noting that similar techniques have successfully detected differences in fertilizer application on corn fields. The same information could be gleaned for managed forests, for example, to detect stress caused by destructive bark beetles.

On a larger scale, Huemmrich says that “most of what we know about how ecosystems respond to climate change and increased carbon dioxide in the atmosphere is from models,” rather than concrete data. If scientists could use satellites, like the ISS, to track photosynthesis in real-time around the globe, that could greatly increase our understanding of how climate change is affecting vegetation. Plants are crucial for managing the global climate, because they take carbon dioxide out of the atmosphere and release oxygen during photosynthesis.

The current gold-standard method for measuring photosynthesis relies on a network of hundreds of “flux towers” around the globe—structures on the ground that detect the flux of carbon in the area by “sniffing the air,” explains Huemmrich, but “the towers can’t be everywhere.” Remote sensing from a satellite would allow scientists to measure carbon fluxes in other places, even those that are inaccessible from the ground.

The new JCET study demonstrates an effective way to do just that, using images taken by the hyperspectral imager for coastal ocean (HICO), which is mounted on the ISS. Petya Campbell, a JCET scientist who was second author on the study, analyzed 26 total HICO images of three sites. Her analysis determined the photosynthetic productivity of vegetation canopies by detecting their reflectance of different wavelengths of light. Reflectance is a reliable measurement of photosynthesis because the amounts of different compounds present in leaves (such as chlorophyll and water) determine the plant’s photosynthetic activity, and each reflects differently.

The team found that multiple algorithms they used with the HICO data matched well with the tried-and-true data coming from the towers, providing strong evidence that this method of remote productivity monitoring can work well in both grasslands and forests. After further confirmation, researchers will be able to trust data about areas not also covered by flux towers. That’s an important advance, Campbell explains, because remote imaging spectroscopy “provides the only practical approach to map canopy functional traits, which are impossible to frequently measure on the ground and comprehensively map across space.”

In some cases, the measurements deduced from HICO data also provide information that flux towers can’t. Remote sensing does a better job distinguishing boundaries in a landscape, such as where a farm field transitions to a forest, and it also performs better on slopes. Plus, data collected by instruments on the ISS are unique because the space station is not in a “sun-synchronous” orbit, which means it passes over the same locations on Earth at different times of day. That allows researchers to detect differences in photosynthesis between morning and afternoon, as well as throughout the growing season and from many viewing angles.

Since the submission of Huemmrich and Campbell’s study, HICO has gone offline, but that doesn’t mean this kind of work is over. A new spectrometer is headed to the ISS in 2018, as well as other instruments that can measure water evaporating from leaves, plant fluorescence, and heat stress. “If NASA had asked me what four instruments I would want in space to study plants, that’s what I would have told them,” Huemmrich says. “Now we’re looking forward to having all four of these instruments on the space station and being able to do something with them.”

Learn more from the full article published in IEEE Journal of Special Topics in Applied Earth Observations and Remote Sensing.

Image: The international space station, provided by NASA.

President Hrabowski signs letter urging U.S. Congress to take action on DACA

UMBC President Freeman Hrabowski has joined nearly 800 other college and university presidents in signing a letter to Congressional leaders urging them to pass a long-term, legislative solution to protect “dreamers”—undocumented immigrants brought to the United States as children—from deportation. The move follows President Trump’s decision to rescind the Deferred Action for Childhood Arrivals policy implemented by President Obama in 2012.

The letter, coordinated by the American Council on Education (ACE), does not put forth specific legislation, but cites polls that show a majority of Americans support a permanent solution that would allow dreamers to remain in the United States. It reminds Congress that DACA recipients are “Americans in every way but immigration status” and “have made incredible contributions to our country and its economy and security.”

“Over the past several decades, researchers have found that students who attend culturally diverse colleges and universities experience greater intellectual benefits than those who do not,” says David Di Maria, associate vice provost of international education at UMBC. “As a world-class university, UMBC is strengthened by the diverse perspectives dreamers bring to our classrooms, the discoveries they make in our laboratories and the service they provide to communities based here in Maryland, across the United States and around the world.”

The ACE letter is one of several ways UMBC has shown support for dreamers and the positive contributions they make to the United States. As early as November 2016, President Hrabowski co-signed a statement urging business, civic, religious and non-profit sectors to support DACA and undocumented immigrant students, and offering to meet with government leaders to discuss the issue. More than 700 higher education institutions have joined the statement since then. President Hrabowski also co-signed a similar letter to President Trump in March with more than 560 college presidents. In addition, he has signed on to the CEO Action for Diversity and Inclusion pledge, a broader commitment to advance diversity and inclusion in the workplace.

As an institution with students, faculty, and staff from more than 100 countries, UMBC knows the value of bringing diverse minds together in the pursuit of knowledge and solutions to society’s greatest challenges.

“At UMBC, we are committed to supporting all members of our community, and we recognize that each person brings a valuable perspective and set of  experiences to our campus,” says President Hrabowski. “It is important for our country to support dreamers, not only so that they can live fulfilling and purposeful lives, but also so that our country can benefit from the ideas and skills they bring to society.”

Visit UMBC’s Diversity and Inclusion site for more information about resources available to the UMBC community, programs and student organizations dedicated to supporting diversity and inclusion, and related UMBC policies. 

GRIT-X talks showcase experiences of outstanding faculty and alumni “from outer space to inner space”

Nine distinguished faculty and alumni shared their stories at GRIT-X, a TED talk-style event during UMBC’s Homecoming. Karl Steiner, UMBC vice president for research, introduced the event, which debuted at last year’s 50th anniversary celebration. “We’ll take you from outer space to inner space,” he said, “from black holes in the universe to a pacemaker for the brain.”

Kafui Dzirasa ’01, chemical engineering, kicked off the program by discussing the latter. Now associate professor of psychiatry and behavioral sciences at the Duke School of Medicine, Dzirasa has a personal connection to his groundbreaking work. “My family has struggled with mental illness for generations,” he shares. While much mental health research has focused on chemical imbalances in the brain, Dzirasa is using new tools and techniques to detect rhythmic waves of electric pulses in the active brain.

“These rhythms work together in the same way that a conductor can allow all the instruments in a symphony orchestra to work together to produce music,” he says. “These little rhythms allow brain cells to coordinate—to produce motions, and thoughts, and feelings.” He calls these rhythms the “metronomic system” of the brain, and is investigating whether psychiatric disorders, such as bipolar and schizophrenia, are a result of faulty metronomes. Dzirasa’s lab is learning about how these metronomes function through animal studies, and he hopes to one day apply the results to humans.

“In the future that I see, our family members would have lived out their life’s greatest dreams,” he says, “because we won’t simply treat psychiatric disorders by tuning electricity, we will cure them.”

Christine Mallinson, professor of language, literacy, and culture, is looking to cure a different ill: the negative biases teachers may harbor against students who speak differently than they do, even if they’re speaking English. Hearing “coffee” pronounced several different ways as a child sparked Mallinson’s lifelong interest in linguistic diversity, which she says “is a resource, not a deficit.”

Demonstrating the value of diverse linguistic patterns in the classroom shows students they are valued, which makes them likely to value school, Mallinson explains. Overall, educators must “give the students the tools they need to succeed on the tests that we require of them, while sustaining and empowering their diverse voices,” she says, “so that we can have all our students with all their diverse voices right here in the front row of our classes at UMBC.”

Nilanjan Banerjee, associate professor of computer science and electrical engineering, is working on wearable sensors—communication of a very different kind. After the iPhone revolutionized “smart” technology in 2007, he says, “Ten years later, we are at the brink of yet another revolution: the revolution of the next generation of wearables.”

Banerjee explained how these tiny computers can make people with spinal injuries more independent, by allowing them to control appliances or communicate via motions as minute as tongue movements. Ankle straps could track health-related statistics from sleep patterns to cardiac conditions, reducing the strain on clinics facing an ever-increasing demand for services as the population ages. Banerjee also sees applications in driving safety, with sensors able to detect whole-body movements that may indicate distracted, drunk, or drowsy driving.

Banerjee acknowledges that “all of these sensors are useless unless people use them,” so this work requires perspective from an array of disciplines, such as human-centered computing, design, software development, and materials science. And of course, privacy and ethics concerns loom large when devices are collecting this much data. To conclude, Banerjee encouraged audience members to “think about what you want these next-generation wearables to do, and more importantly, think about what you want them not to do.”

The second session began with Sean Pang ’09, English, and M.A. ’11, teaching, who recounted his “fortune of misfortunes,” including culture shock and a language barrier upon his immigration to the U.S. as a small child, and poverty and eviction during his undergraduate studies. When he started teaching in Baltimore City after graduating from UMBC, he was the only Asian person in the room, but his background of challenges helped him connect with students. “When they see me come into the classroom, with a smile on my face, with passion, and dedication, and kindness, they see hope,” he shares, “hope that they can make something better from their lives.”

Pang, who was The Washington Post’s 2017 Teacher of the Year, had three recommendations for audience members. First, he said, be kind. In kindergarten, a classmate gave him a plastic dinosaur that Pang keeps to this day—it was the first act of kindness he remembers from a peer in the U.S. Second, “Try everything, because that will lead you to find your passion.” And once you find it, “use it to give hope, because hope is the greatest gift you can give.”

Gymama Slaughter, associate professor of computer science and electrical engineering, is hoping for a future of implantable medical devices that are safe, environmentally friendly, and powered by the metabolism of our own bodies. Her lab has created thin membranes made of nanocellulose—a flexible, permeable, transparent, biocompatible material produced by genetically engineered bacteria—and tiny attachable circuits that harness the body’s energy. Because the byproduct of the energy production process is simply water, it’s completely safe.

So far, Slaughter’s bio-power devices, only a few millimeters on a side, can light up an LED light. “This gives us hope that eventually, with such a small device, we can develop a power system that harnesses the biochemical energy of glucose within our body,” she says, “to power implantable devices that can monitor disease, diagnose diseases, and one day deliver therapeutics into our body to enable our bodies to heal.”

Kate Brown, professor of history, closed the second session with a talk on radioactive blueberries. Brown traveled to the Chernobyl zone expecting to find sadness and isolation. Instead, she found a booming, revitalized economy based on foraging—blueberries in the summer, cranberries and mushrooms in the fall.

“These women and children pickers have made it happen with human-powered resourcefulness. So economically it’s a good idea,” Brown says. “What about biologically? That’s a trickier question.” Brown explains that berries are extremely efficient at absorbing radiation from the soil, and limits have been set on the radiation level allowed in the EU market. But the berries are simply marked as “wild and organic,” so consumers have no idea they are ingesting radiation. There is very little research on the effects of long-term, low-dose exposure to radiation, but in the area surrounding the berry picking region, birth defects are six times as high as the European average.

“I’m here to tell you that even though we think of Chernobyl as something that’s very far away, it’s being brought to us by the global market that’s been so successful,” Brown says. She recommends paying the pickers the same amount to pick the berries, except then disposing of them as waste in the effort to reduce radiation in the area.. Brown even speculates that tourists might be willing to pay to experience picking radioactive berries. “That might be a better way of solving this problem, than just pretending it’s not happening.”

Next, Jane Turner, director of UMBC’s Center for Space Sciences and Technology and professor of physics, took listeners much, much farther away to black holes at the centers of galaxies. The Milky Way contains a black hole 2.6 million times as massive as our Sun, she explained, and “there’s evidence for supermassive black holes at the center of all galaxy nuclei. This is one of the big discoveries of the last decade or so in astronomy.” These black holes are proportional in mass to the mass of the galaxy they’re in, so “these things must grow together,” she says.

Most of the black holes at the centers of galaxies are dark and only detected by their gravitational influence, but a few percent emit an incredible amount of light—these are called “active nuclei.” Turner’s work involves investigating why those few are so bright, by looking at X-rays coming from very close to the black hole “event horizon,” beyond which we cannot make observations. These X-rays can tell scientists about what material is present close to the black hole and how that material is moving. Astrophysicists like Turner have found that black holes are pulling in about one star’s-worth of material per year, which is “enough to feed these active nuclei.”  The black holes are also pushing some of that material back out —enough to affect star formation in the surrounding galaxy. It’s by analyzing results like these, Turner says, that “we’re going to be able to understand the connection between the growth of the black hole and the host galaxy, and from that the growth of structure in the universe on the whole.”

While black holes are helping build galaxies far away, Corey Fleischer ’08, mechanical engineering, is helping people build things in Maryland. As co-founder and general manager of The Foundery, a makerspace in Baltimore, Fleischer’s goal “is to have anybody walk in with a hand sketch on a napkin, for a product or an invention they want to build, and with our tools and classes be able to walk out with a polished, professional-looking prototype.”

Fleischer’s career path has been largely informed by his experience on UMBC’s mini-Baja team, which involved designing and constructing a one-person vehicle and then navigating it around an obstacle course at competitions. “We were learning textbook knowledge in classrooms, but at the same time we were learning firsthand how to build things,” he says. The Foundery provides a space for people with ideas to make them reality, and quickly, by speeding up the design feedback cycle—which involves a lot of failure. “Failure is an empowering way to learn,” Fleischer says. “And makerspaces allow people to fail faster.”

Finally, Doug Hamby, associate professor of dance, and two UMBC dance students, Emily Godfrey ’20 and Samantha Siegel ’18, created an original dance right before the audience’s eyes. Hamby gave them instructions and they absorbed them on the spot, performing turns, rolls, and pliés to the audience’s delight. “When I make a dance,” Hamby shared as he moved fluidly across the stage, “I like to think of it as an investigation of the human body in motion, and in space, and in time.”

After the dancers performed the full sequence to close the program, Hamby tied all the GRIT-X talks together. “That’s one of the ways art is made,” he said, “through serendipity and experimentation.” Replace “art” with language, science, or technology, and the statement holds. UMBC faculty and alumni are creatively exploring the edge of knowledge, and the physical and mental world, from inner to outer space—from black holes to brain pacemakers, from language usage to radioactive fallout, from driver safety to dance—and sharing it with the world.

Watch videos of the complete GRIT-X presentations to learn more.

Banner image: Sean Pang ’09, English, and M.A. ’11, teaching, chats with his wife (right) and President Hrabowski (left) after his presentation. All photos by Marlayna Demond ’11 for UMBC.

UMBC’s comprehensive partnership with Lakeland School boosts math performance

UMBC’s partnership with Lakeland Elementary and Middle School in Baltimore has grown steadily over the last five years, and it bore measurable results this spring: Lakeland performed much above the Baltimore City average, and slightly better than the state average, on the math portion of the PARCC, Maryland’s state test. While less than 20 percent of students in Baltimore passed, almost 50 percent of Lakeland students did, and Lakeland saw big improvements from the previous year. Everyone involved agrees the partnership with UMBC played a major role in the achievements.

“This is not your average partnership,” Carly Harkins, Lakeland math teacher, shared with The Baltimore Sun in a feature story that appeared on the front page. “This is my 16th year teaching, and I’ve never seen anything where the schools are so connected in so many ways.”

The relationship includes professional development for Lakeland teachers, especially around how to use testing data to guide instruction to more effectively address students’ learning gaps. In collaboration with Northrop Grumman, a $1.6 million STEAM (science, technology, engineering, arts, and math) center is currently under construction, and STEAM activities, like family nights at the school, are already taking place. Lakeland students attend UMBC basketball games and special events like the “Hour of Code,” which focuses on computer science, and there are summer and after-school enrichment programs for students and parents. Last year, the partnership expanded to include a math coaching program, where UMBC students travel to Lakeland and work with small groups of students during the school day.

“We love the term math coaching, because not only are we there to help build the skills and help students develop their math processing, but it’s a lot about building a culture of math and STEM at Lakeland,” Josh Michael ’10, political science and education, and assistant director of UMBC’s Sherman STEM Teachers Scholars Program, told Sheilah Kast on WYPR’s On the Record. “A coach may pump you up or help motivate you, and that’s the way we approach math and STEM in our partnership.”

Many of the 26 coaches this year are Sherman scholars, while others are STEM or education majors who have an interest in giving back to the community. Michael says the goal of the scholars program is to develop “culturally responsive and compassionate” teachers. Several are Spanish speakers, which is helpful at Lakeland, where 48 percent of students are Hispanic and one-third of students are English language learners.

A few former coaches are now teachers at Lakeland, such as Jasper Barnes ’17, interdisciplinary studies, whom the students refer to simply as “Coach.” Whether a math coach pursues a career at Lakeland or not, they’re “having an awesome experience in a community school, and they’re contributing to the learning needs and learning engagement of the young people at Lakeland,” Michael told WYPR.

The benefits radiate in every direction. “Some of these children one day should be able to come to UMBC and then go on to work at Northrop Grumman,” President Freeman Hrabowski told the Sun. “It’s almost like an ecosystem that goes all the way from early education through a career.”

“It’s an incredible program and an incredible partnership with UMBC,” shared Lakeland principal Najib Jammal with CBS Baltimore. “It’s the difference of the students getting that extra support and building that confidence to feel like they can be successful in the classroom and in life.”

Learn more in the complete coverage:
UMBC students coach Lakeland Elementary/Middle School students with positive results (Baltimore Sun)
A partnership ignites a STEM spark (WYPR’s On the Record)
UMBC partnering with Baltimore school to improve students’ math skills (CBS Baltimore)

Image: UMBC students volunteer at Lakeland. Photo by Marlayna Demond ’11 for UMBC.

Noemi Petra first UMBC graduate to receive NSF Career Award in Mathematics

Noemi Petra, Ph.D. ’10, M.S. ’07, applied mathematics, has always been a hard worker. In her dissertation research at UMBC, she forayed into engineering applications, mathematical theory, and computational techniques to answer questions about sensors that detect trace gases, such as carbon monoxide.

“Most math students delve into one of these three general areas of research during their Ph.D.,” explains one of her mentors, John Zweck, former UMBC faculty member in mathematics and statistics. Petra tackled all three.

Petra’s grit has paid off. The National Science Foundation has recognized her ongoing research success with the NSF Career Award, intended to support early-career faculty “who have the potential to serve as academic role models in research and education and to lead advances in the mission of their department or organization.” It is one of the most prestigious awards an early-career STEM researcher can receive. Petra’s award, the first for a UMBC graduate in mathematics, provides $400,000 for her work over five years. Previous UMBC Career Award recipients have supported faculty projects in areas as diverse as developmental biology and artificial intelligence.

The first in her family to attend college, at the University of Babes-Bolyai in Romania, Petra’s willingness to take on new challenges has served her well throughout her career. After UMBC, she was a postdoctoral fellow and then a research associate at The University of Texas at Austin within the Institute for Computational Engineering and Sciences (ICES)  in the prestigious Center for Computational Geosciences and Optimization led by Professor Omar Ghattas, who was also Petra’s postdoctoral mentor. From there, Petra transitioned to the University of California, Merced, where she is now an assistant professor and maintains collaborations with a variety of renowned institutions.

“I think the experience of having to make progress on a very applied problem turned out to be an excellent training ground for Noemi,” explains Zweck, now professor of mathematical sciences at University of Texas at Dallas, “because it gave her the confidence and experience to tackle much harder applied problems in her postdoc and now in her faculty position.”

Her research interests have evolved from gas sensors to other applications for similar mathematical techniques. One of her current projects seeks to model how ice sheets flow using differential equations—a very difficult problem, considering it’s impossible to directly observe some of the required parameters. She applies the same type of problem-solving to model power distribution in electrical grids, which could help make them more efficient in the future.

Petra sees the award as “the result of a long, but extremely exciting and rewarding professional journey.” In particular, she says, UMBC “offered the perfect environment to grow as a researcher and educator. The careful mentorship during my Ph.D. and the diverse set of graduate classes I took at UMBC helped me obtain a very successful postdoctoral fellowship, which led to where I am today. For this I am very grateful.”

“Noemi was a wonderful student to work with,” shares another of Petra’s mentors, Susan Minkoff, faculty in the UMBC math and statistics department from 2000 – 2012 and now at the University of Texas at Dallas. “I felt like we were losing a friend when she graduated.”

Petra says Minkoff “helped me a lot to build confidence and not feel intimidated in a male-dominated environment such as STEM,” and now she plans to support future generations of mathematicians. The award will allow her “to undertake an ambitious agenda that includes cutting-edge research and mentoring for students at the undergraduate and graduate levels,” and she is particularly looking forward to dedicating “a significant part of my efforts toward mentoring and preparing students for careers in applied mathematics and computational science.”

Part of that mentorship will involve teaching students how to handle the uncertainty inherent to her field. “Finding the right problem to solve goes hand-in-hand with the solving process,” she says, which is part of what makes the work exciting. “It is like going on a trip without knowing a specific destination.”

– Sarah Hansen M.S. ’15

Photo credit: Veronica Adrover for UC Merced

UMBC participates in national study on Ph.D. career pathways at pivotal moment for new grads

UMBC is one of 29 universities nationwide joining forces to better serve Ph.D. students by examining the broad range of pathways they take from graduate school to career. The Ph.D. Career Pathways study is backed by the National Science Foundation and Andrew W. Mellon Foundation and organized by the Council of Graduate Schools. It will provide much-needed data on graduate students’ experiences and perspectives at a pivotal moment when career possibilities for Ph.D.s are changing substantially and universities are searching for ways to better prepare students for opportunities and challenges ahead.

“The assumption that the Ph.D. is primarily a pathway to the professoriate is just not the case,” says Janet Rutledge, dean of the UMBC Graduate School. “We’re hoping that by being part of this study, we will determine the best ways to focus our time and our resources to most effectively guide our students.”

UMBC and Morgan State University are collaborating as partners in the study, which will include students in graduate programs across the humanities and STEM. Morgan is the only participating HBCU, and UMBC is one of only six Minority-Serving Institutions, and the only one outside of the University of California system. The diversity of participating institutions will be essential to the study’s success, Rutledge notes, explaining, “If we’re trying to get a view of what the pathways are for students then we need to have a variety of universities represented.”

In addition to the Ph.D. Career Pathways study, UMBC is participating in the Coalition for Next Generation Life Sciences, which will investigate graduate program alumni pathways specifically in the life sciences. This study is led by Johns Hopkins and University of California, San Francisco, and also includes UMBC, Cornell, MIT, University of Michigan, University of Pennsylvania, and University of Wisconsin.

Of course, Rutledge points out, “Before you can survey alumni, you need to find out where they are.” Funding from the two projects together will support a graduate student research assistant to gather that information through contacting alumni networks, scouring social media, and interviewing department chairs and faculty.

In addition to supporting current UMBC students, Rutledge hopes UMBC’s participation in the Ph.D. Career Pathways study will help students considering pursuing a Ph.D. at any institution. “People undertake Ph.D.s without always having a full sense of what the experience will be like or what it could mean for their future,” she says. “We want to have more transparency for current and prospective students to help them understand job and career pathways with a Ph.D., and how you go about finding opportunities.”

Rutledge also sees great potential for this kind of research to help grow universities’ relationships with companies, government agencies, and other non-academic research institutions, which are often trying to reach talented researchers early in their careers. Connecting UMBC graduate students with internship and work opportunities through these partners could help those students access broader career opportunities, help employers access a highly skilled and diverse talent pool, and boost research collaborations and resource sharing among partners.

Already, successful partnerships of this kind have been “a win-win for the mentor and the student,” says Rutledge.

Ph.D. Career Pathways surveys, developed by the Council of Graduate Schools, will be implemented this year, with the first data coming in next fall. Rutledge and her team are excited to be part of such an important national study in graduate education, but their focus always comes back to the scholars they work with every day. “We really want to understand the pathways of our current students and our alumni, as well as learn how other universities support their graduate students, so that we can better serve UMBC graduate students of today and of the future.”

Image: New UMBC graduate students get to know each other and learn about ways to become involved at the Graduate Student Information Fair. Photo by Marlayna Demond ’11 for UMBC.

UMBC researchers win USDA grants to improve safety and efficiency of fish farming industry

Global demand for fish is growing quickly, but many species are already severely overfished, leaving scientists and industry experts searching for ways to more safely and efficiently farm fish. In response, two UMBC research teams are developing revolutionary innovations for off-shore fish farming, to help mitigate the risks of disease and escapes in captive fish populations. Both recently received extremely competitive awards from the U.S. Department of Agriculture (USDA) to pursue their work further.

Yonathan Zohar, professor and chair of marine biotechnology, explains that the teams’ work “makes the point of how you can use advanced approaches and strategies of biotechnology to open some of the major bottlenecks in the aquaculture industry.”

Any time a large number of individuals of any single species is in a confined space—from fish to chicken to trees—disease can spread easily, as all members of the group share the same vulnerabilities. That’s why farmers vaccinate their animals against each species’ most common foes. For rainbow trout and salmon, two of the most popular food species in the United States, one danger is infectious hematopoietic necrosis virus (IHNV).

An effective vaccine to protect fish from IHNV is available, but it must be injected individually into every fish at a cost of $0.30 per dose. That makes its application extremely labor-intensive and expensive. Vikram Vakharia, professor of marine biotechnology, has taken on the task of developing a new oral vaccine for IHNV that can be delivered in fish food, which would drastically reduce labor and costs.

To produce the vaccine, Vakharia infects cabbage looper larvae (a common moth species) with a virus that is genetically engineered to produce the protein that comprises the outer shell of IHNV, surrounding its genetic material. By freeze-drying and grinding up the larvae, sprinkling the powder on fish food pellets, and feeding the augmented food to fish, the protein gets into the fish’s system and triggers immunity to the disease without making them sick. “I’m using insect larvae as a factory” to produce the protein, which serves as a vaccine, Vakharia explains.

A new USDA grant Vakharia has received will enable him to focus on improving the delivery mechanism’s efficiency to ensure all fish in a treated population are protected. “Here is an approach to provide a new generation of vaccines that are edible,” says Zohar. “The possibility of delivering the vaccine through the feed is a major breakthrough.”

Ten-Tsao Wong, assistant professor of marine biotechnology, and Zohar are tackling a different issue facing off-shore fish farms: the risk of escapee fish. Wong’s project doesn’t prevent fish from escaping from their pens, but it renders them sterile, limiting the ecological damage they can do if they ever escape.

Because escaped farmed fish would be unable to mate with wild fish, wild populations would be protected from taking up genetic material from captive fish, which could be detrimental to the wild populations’ survival. This also would prevent captive fish from acting as an invasive species that eventually eradicates native individuals.

Just recently, thousands of non-native Atlantic salmon from a floating net pen farm in the Pacific Northwest escaped, with the potential to out-compete native salmon, causing widespread concern in the fishing industry as well as among scientists and environmentalists. “We want to limit this kind of risk,” Wong says. “Once you have a sterile fish, even if they escape, they’re not able to reproduce.”

In addition, sterile fish “can be more cost-effective,” says Wong. “Because they don’t develop gonads [reproductive organs], they can put more energy into muscle development.” In addition, reproductive hormones can weaken a fish’s immune system, so sterile fish can be more robust in the face of health threats.

Rather than genetically modifying the fish, which would make them a GMO food and alienate some consumers (as well as be illegal in the U.S. aquaculture industry), Wong simply places fish eggs in a bath containing a drug that, at a specific, early window in development, prevents their reproductive organs from growing later on. In an initial trial, Wong’s technique had an 84 percent efficacy rate in salmon. “The technology is working, and the conditions need to be optimized,” he says. “The new funding will help us move forward and enhance the efficiency.”

Vakharia and Wong were selected as the only award recipients in their respective categories in a call for proposals from the USDA this spring, and both projects were supported at maximum funding levels—an expression of the agency’s belief in the importance of the work.

For both projects, “the proof of concept is there,” says Zohar. “Now it’s about optimizing the system so it can be a tool for the industry.”

Image: The Institute of Marine and Environmental Technology on Baltimore’s Inner Harbor, which houses UMBC’s marine biotechnology department. Photo by Marlayna Demond ’11 for UMBC.

UMBC marine biologist Colleen Burge works to save world’s oysters from deadly herpes virus

Colleen Burge, UMBC assistant professor at the Institute of Marine and Environmental Technology, made a splash with her new article in The Conversation warning of the danger posed by a herpes virus that is decimating oyster populations around the world. Burge conducts research seeking out genes that trigger disease resistance in oysters, potentially offering one path toward protecting this valuable, and vulnerable, marine animal.

Infection by the herpes virus, known as OsHV-1, is usually fatal for Pacific oysters, “the world’s most popular and valuable oyster species,” Burge writes. The Pacific oyster is native to Asia, but the virus has been wreaking havoc on transplanted oyster populations worldwide, from Tasmania to France, since its emergence in the 1990s. Making things worse, the virus has recently mutated to form several “microvariant” strains that are even more deadly. Burge was a member of the team that discovered the virus in two bays along the California coast for the first time in the early 2000s, but so far no microvariants have been found in North America.

“Given the spread of the OsHV-1 microvariants elsewhere around the world, it may only be a matter of time until they reach U.S. coastal bays or other non-impacted oyster growing areas,” Burge writes. That means finding a way to prevent massive oyster die-offs, which have already happened in other parts of the world, is important to save the species.

Beyond their economic and cultural value to the fishing industry, oysters are also prized for the work they do to support aquatic environments. Each oyster can filter up to 50 gallons of water per day and oyster reefs provide habitat and food for fish, including popular commercial species. The spread of a deadly infection among oysters could put all this at risk.

Oysters can’t be vaccinated against the virus, because their immune systems lack the “memory” that benefits more complex organisms, Burge explains. “The most effective strategy to date has been developing disease-resistant oyster lines, which can limit both mortalities and oysters’ susceptibility to infection,” she says, but even that technique comes with caveats.

To test disease resistance, scientists must infect oysters with the virus. Placing those oysters into a wild population that hasn’t previously been exposed to the virus is too great a risk, so scientists are only able to try this technique in areas where the virus already exists, limiting its use. Traditional selective breeding could also produce disease-resistant oysters. Burge is taking it one step further, looking directly for genes involved in resistance.

Burge emphasizes that “the most effective way to limit damage in new locations from OsHV-1 is to limit its spread.” If that becomes impossible, however, introducing resistance will be critical. “Oysters can’t move themselves out of harm’s way, nor can we move all susceptible oysters,” she writes, “so we need to protect them where they grow.”

Colleen Burge’s article, “A deadly herpes virus is threatening oysters around the world”, has been viewed  more than 146,000 times and republished by Smithsonian Magazine, The Raw Story, Phys.org, The New Food Economy, and others.

Image: Oysters. Photo by Paul Asman and Jill Lenoble, used under CC BY 2.0.