All posts by: Sarah Hansen, M.S. '15


UMBC’s Qianqian Song receives FINESST Fellowship from NASA for research on dust clouds and climate

UMBC’s Qianqian Song has just received the Future Investigators in NASA Earth and Space Science and Technology (FINESST) Fellowshipone of just 59 such fellowships granted nationwide this year. The award provides $45,000 per year for three years for her to continue her studies at UMBC with Zhibo Zhang, associate professor of physics.

Song, a fourth-year Ph.D. candidate in atmospheric physics, is studying how dust above clouds affects the global climate. Large amounts of dust enter the atmosphere when strong winds blow across dry areas, such as the Sahara Desert. Previous research from the Zhang lab showed that this dust travels thousands of miles and provides critical nutrients to the Amazon rainforest. Other studies have suggested that the dust has an overall cooling effect on climate, by blocking short-wave radiation coming from the sun. “But they were neglecting the long-wave effect,” says Song. This is where her innovative work comes in.

As long-wave radiation rises into the atmosphere from Earth’s surface, dust can block it from exiting the atmosphere, producing a warming effect. “In our research we found that the dust’s long-wave warming effect cancels about 30 percent of the short-wave cooling effect,” Song explains. Incorporating this new understanding into climate models could have a significant impact on the models’ predictions.

Now Song wants to learn more about how the dust interacts with nearby clouds: How does it affect the size of water droplets in the clouds, or how densely the droplets are packed together? Massive amounts of data obtained by NASA satellites and aircraft and powerful computational tools will assist Song as she works on answering these challenging questions.

Embracing change at UMBC

Qianqian has come a long way since her 2014 arrival in the U.S. from China with her husband, who had obtained a student visa to pursue a Ph.D. in electrical engineering at Johns Hopkins University. Coming to the U.S. “was a big change,” she says. For one, “When we came, our English wasn’t good. It was hard. But now it’s much better.”

After a year, Song decided to pursue her own Ph.D. “When I visited UMBC, I felt like everyone knows each other and supports each other in the physics department,” she remembers. “That’s why I chose here.”

Some of Zhibo Zhang’s lab members, clockwise from lower left: Qianqian Song, Chamara Raja, Kevin Zheng, Zhibo Zhang, and Olivia Norman. Photo by Marlayna Demond ’11 for UMBC.

However, the visa process proved challenging, and she thought she would have to postpone her enrollment another year. But physics graduate program director Todd Pittman stepped in. “He talked to the whole department,” Song says, and got department chair Michael Hayden’s support for a special, temporary scholarship for Song to initially join the UMBC community as a part-time student. She dived into her courses and research rotations, and the next semester Song was able to finalize her visa and begin her full-time studies.

A rotation in Zhang’s lab sparked Song’s interest in atmospheric research. “Before I came here, I did my master’s degree in Beijing. The pollution there is very severe,” Song shares. “So since living there, I am interested in atmospheric science. When I did a rotation with Dr. Zhang, I did research on dust aerosols, and I got very interested in learning about their role in climate change.”

Pursuing her dream

Now, Song is excelling. “I think she is rising to become a future leader in our field,” says Zhang. 

Song shares that UMBC’s supportive network has had a major impact on her experience. “Dr. Zhang is an excellent adviser. He teaches us communication skills and helps us a lot in our research,” she says. In this research group everyone helps each other, not only on our research but also in our personal life.”

That’s been important for Song, who recently welcomed her first child. The flexibility to work and participate in meetings from home, when needed, allowed her to continue her research at full speed while she was pregnant and now, as she raises her baby with her husband. “I was in my third trimester when I was writing the fellowship proposal,” she shares.

Song plans to pursue a career in academia after her Ph.D. “That’s my dream,” she says. With the support of the fellowship, her lab group, and her family, Song will pursue it with confidence.

Banner image: Qianqian Song discusses her research findings with her lab team. Photo by Marlayna Demond ’11 for UMBC.

UMBC’s Tom Cronin, mantis shrimp vision expert, receives international Rank Prize for Optoelectronics

Tom Cronin, professor of biological sciences, and his longtime colleague, Justin Marshall, professor at the University of Queensland in Australia, have received the 2020 Rank Prize for Optoelectronics. The prize honors their pioneering discovery of new ways that eyes can perceive color and a rare type of light that has twisted electromagnetic waves, called circular polarization.

Lord Joseph Arthur Rank established the Rank Funds for Nutrition and Optoelectronics in 1972.  Each year, the fund committees designate prize winners in each category from an international pool of nominees. Past winners have included Mike Land of the University of Sussex, who is considered by many to be the top expert on comparative vision internationally, and Jeremy Nathans of Johns Hopkins University, who was the first to determine the DNA sequence for the visual pigments in human eyes. 

Cronin and Marshall’s award includes an unrestricted £40,000 for each recipient and a trip to London for the award ceremony on January 20, 2020. On receiving the prize jointly, Cronin says, “We’re both very glad that both of us were included. It’s been more than 30 years that we’ve been working side by side.”

Cronin and Marshall’s first joint effort, in 1988, resulted in an article that graced the cover of Nature, generally considered to be the most prestigious scientific journal in the world. With such a strong start to their collaboration, the duo decided to keep a good thing going. Since then, “Justin and I have published almost all of our work jointly. There’s very little that we do that hasn’t involved both labs,” Cronin says.

Marshall sees the collaboration as born out of mutual interests that have only grown over the years. “We see ourselves as a couple of guys interested in nature,” he says, “and the way we study it has made us get to know a fair bit of biology, but also other areas of science, like physics and chemistry, and how it all fits together in a discipline called visual ecology.”

The world’s weirdest eyes

The two researchers focus on the visual system of the mantis shrimp, which is “just extraordinarily strange,” Cronin says. He explains, “Justin and I both work to develop understanding of this very complex, extremely unusual, and very dynamic visual system that’s unlike any other that’s ever been described.”

“Basically,” says Marshall, “we got a prize for describing weirdness beyond our wildest dreams.” For example, mantis shrimps have more color channels than any other animal that humans know of. The colorful critters have at least eight, and possibly as many as 16, channels. In comparison, humans have only three. Some channels allow the shrimps to see ultraviolet light, while the large number of channels in the visual light spectrum may allow them to identify colors more quickly.

On top of that, “Mantis shrimps combine this color vision system with a very complicated polarized light vision,” Cronin says. Light can be polarized linearly—that’s why your camera screen looks black when you’re wearing polarized sunglasses. “There’s another kind of polarization that’s far rarer, and optically complex, but that mantis shrimps can see. It’s called circular polarization,” Cronin explains. In fact, mantis shrimp are the only animals known to be able to see circular polarization.

Some mantis shrimps have circularly polarized markings on their bodies, which has led researchers to hypothesize that mantis shrimps may use their circularly polarized vision to identify other individuals as potential mates or competitors. 

Camouflage, cancer, and mantis shrimps?

One might ask what mantis shrimp vision has to do with optoelectronics. The number of scientists doing basic research who are among the Rank Prize winners speaks to the importance of projects that lay the foundation for work on applications, Cronin says. “A common misconception is that if you don’t work in an optoelectronics lab, or if you don’t work with mice and zebrafishes, you’re not going to discover anything important,” he says. “And that’s just not true.”

Cronin and Marshall’s work to understand how mantis shrimps detect polarized light, and specifically circularly polarized light, has a range of applications. A medical technology for guided breast tumor surgery is currently in development, for example. 

Cronin adds, “Circularly polarized light can also be used to ‘see’ objects that are otherwise camouflaged, which is why we get funded by the military.” The unusual light can also assist in navigation that doesn’t require GPS satellites.

Marshall agrees about the value of foundational research. “We did not set out to solve these problems,” he says, “but we found solutions along the way.”

A lifetime of achievement

Mantis shrimps have rocketed to public fame in recent years, in part due to research out of Cronin’s lab and his appearances in media such as the podcast RadioLab. “I think public outreach is very important,” says Cronin, who estimates he’s contacted by at least one media outlet per month. “You need people to be interested in the fact that science is exciting, and it’s a frontier.”

The selection committee, guests of the Rank Funds, and family members and guests of the recipients will attend the celebration in London. Cronin’s colleagues plan to travel from institutions across the globe to attend the event, where he’ll give a brief acceptance speech on his and Marshall’s behalf.

“We make a great team and have been lucky over the years to work with others who also share our passion,” shares Marshall. 

The prize “recognizes a lifetime of achievement and is an exceptional honor,” Cronin says. “It will be exciting to be there with all my colleagues from 40 years of research.”

Image: Peacock mantis shrimp (Odontodactylus scyllarus) with eggs. Photo by Christian Gloor, used under CC BY 2.0

Leadership Montgomery recognizes UMBC’s Annica Wayman and Sunil Dasgupta

Leadership Montgomery has selected Annica Wayman and Sunil Dasgupta, both of UMBC at The Universities at Shady Grove, to join the newest cohort of the Connecting Our Region’s Execs (CORE) program. Wayman ‘99, M6, serves as UMBC’s associate dean for Shady Grove affairs, in the College of Natural and Mathematical Sciences (CNMS), and Dasgupta is UMBC’s program director for political science at Shady Grove.

As CORE participants, Wayman and Dasgupta will take part in monthly interactive sessions, network with other Montgomery County leaders, and visit unique county businesses to learn more about what makes “MoCo,” as it is affectionately known, tick. They are the first members of the UMBC community to be selected since the program’s inception in 1990, an indication of UMBC’s growing presence in Montgomery County through the Universities at Shady Grove.

Supporting Montgomery County

“As UMBC looks to expand in Montgomery County and serve its residents, my participation in Leadership Montgomery will be instrumental,” Wayman says. “Through Leadership Montgomery, I look forward to gaining a deeper knowledge of the issues facing Montgomery County. I will use that knowledge to develop higher education programs at UMBC-Shady Grove that effectively address the county’s workforce needs. I also hope to make lifelong connections with other area leaders, so that together we can better Montgomery County.”

Annica Wayman ’99, M6, mechanical engineering.

Wayman is already taking action toward these goals. She is spearheading the launch of the Translational Life Science Technology Program, a new CNMS bachelor’s degree. This program directly addresses the needs of the region’s thriving biotech sector, and will help local residents access the growing number of jobs in this field. She looks forward to introducing the master’s of professional studies degree in biotechnology to the Shady Grove campus in fall 2019 and developing future programs.

“UMBC-Shady Grove in MoCo plays a critical role in the strategic vision of the college in supporting the Maryland economy and keeping our talent at home,” says CNMS dean Bill LaCourse. “USG is an ideal location for this work due to its proximity to the cluster of biotechnology companies along the I-270 corridor and the high-quality public schools of Montgomery County.”

LaCourse adds, “Dr. Wayman is a talented and experienced professional, and I am delighted that she has been selected as a member of the latest Leadership Montgomery cohort.”

The Universities at Shady Grove.

Serving students from all backgrounds

Dasgupta has committed himself to higher education at UMBC, and at Shady Grove specifically, because of the population of students the campus serves. When he joined UMBC in 2009, he says, “I saw an opportunity to build a program as part of an innovative university known to be at the forefront of what I like to call the democratization of higher education in America. It’s an institution where a large number of students were first-generation college graduates, new immigrants, minorities, and from other groups traditionally not associated with higher education.” Dasgupta shares, “I was excited to be making a difference.”

And he has. For example, in addition to his courses, Dasgupta offers weekly Wednesday Wipeout opportunities for faculty, staff, and students at Shady Grove to gather for discussions of current events. It’s not required for any class, but the room is always packed. It’s a chance for community members from all backgrounds to discuss sometimes controversial issues in a civil format—a valuable skill for everyone. It’s this kind of “above and beyond” effort that sets Dasgupta apart.

Dasgupta has also founded a non-profit, Conexion Escolar, that makes information ordinarily available only to English-speakers more accessible to speakers of Spanish, such as information about K-12 schools in the county. Multilingual college students use their skills to translate the materials. They make connections with families in local communities to help make sure they get the information they need. Conexion Escolar aspires to expand its language offerings in the future.

Students study together at UMBC-Shady Grove.

“For many years, Sunil Dasgupta has led our political science program at Shady Grove with inspiration and dedication,” shares College of Arts, Humanities, and Social Sciences Dean Scott Casper. “He will bring wide-ranging experience to the Leadership Montgomery cohort, while developing valuable relationships that enhance our work in Montgomery County.” 

UMBC’s very best

As the cohort kicks off its year of activities, Christopher Steele, vice provost for the division of professional studies, is thrilled for Wayman, Dasgupta, and UMBC. “We are so proud of Dr. Dasgupta and Dr. Wayman for being selected as members of the 2020 Leadership Montgomery CORE cohort program,” he says. “We are hopeful that they are the first of many UMBC colleagues who will participate in this excellent civic leadership program.” 

Steele shares, “These two remarkable leaders perfectly reflect the fact that UMBC offers its very best to Montgomery County.”

Banner image: Sunil Dasgupta, political science, with students at UMBC-Shady Grove. All photos by Marlayna Demond ’11 for UMBC.

Phage Hunters: Popular UMBC research program opens doors to biotech careers

Viet Dang ’18, biological sciences, originally imagined pursuing medical school after UMBC. But when he took the Phage Hunters course to fulfill his genetics requirement, that changed. “The Phage Hunters class really opened my eyes to all the possibilities, and that I could potentially do research,” he says. Today he’s a microbiologist at Adaptive Phage Therapeutics. It’s a biotech company in Gaithersburg, MD that identifies viruses that attack bacterial cells, called phages, that can fight antibiotic-resistant bacteria for patients in need. He works alongside four other recent UMBC alumni, all of whom participated in Phage Hunters.

UMBC’s Phage Hunters program is a two-course series in genetics and bioinformatics. It aims to increase students’ awareness of their life science career options, such as the biotech industry, and give them a taste of investigative research. Launched in 2008 and based on the national SEA-PHAGES program funded by the Howard Hughes Medical Institute, it’s making a difference in helping students see new career choices as real possibilities.

Often, if students realize medical, nursing, dental, or pharmacy school may not be for them, they leave science altogether, says Steven Caruso, senior lecturer in biological sciences and one of the Phage Hunters instructors. But the five alumni now working at APT and others “decided to stay in science,” Caruso says. “We’ve sent them into UMBC’s applied molecular biology master’s program, or into jobs in industry, and I think it’s directly because of this experience.”

Bri'Anna Horne '17 works at Adaptive Phage Therapeutics.
Bri’Anna Horne ’17 works at Adaptive Phage Therapeutics. (Courtesy of Bri’Anna Horne ’17)

Affirming experiences

Unlike Dang, Anna Kawa ’18, biological sciences, was already interested in research when she enrolled in the course. “All you had to do was sign up for the class,” she says, “and you got a spot in a lab doing wet lab work—which was exactly what I was looking for.”

The Phage Hunters experience aligns more closely with a mentored research experience than with a traditional course, as students are given significant freedom to design and complete their projects on their own schedule. The projects involve taking water and soil samples and isolating phages, viruses that infect bacterial cells. Every semester, students find phages that have never been seen before. As the organisms’ discoverers, the students also get to name the phages. At the end of the semester, the class selects a few phages to send out for DNA sequencing.

“The phages become their babies,” says Ivan Erill, professor of biological sciences and the other Phage Hunters instructor. In the bioinformatics course, the students dive into analyzing the genetic sequences resulting from their discoveries in the first semester. They learn more about what genes their critters have, and at the end they submit the full genome to GenBank, a massive online database of genetic information. “I believe it’s kind of cool to be able to go to a party and say you have your very own critter genome published in GenBank,” Erill says.

Building independence

Many of the students who enroll in Phage Hunters don’t have previous research experience. So how do they go from rookies to competent, passionate, independent researchers who spend hours in the lab at a time? It’s all about the support system.

During the lab’s open hours (9 a.m. to 4:30 p.m. every weekday), graduate and undergraduate teaching assistants take shifts to provide guidance. “The TAs really motivated students and provided a safety net for students with questions,” says Marty Lee ’17, biological sciences. Lee later became a TA for the course himself.  

Caruso agrees that the undergraduate TAs are one of the secret ingredients for the program’s success. “The students are much more likely to ask their peer-level TAs questions and get help when they need it. Having them there allows me to interact with more students,” he says.

Viet Dang '18 works in the lab at Adaptive Phage Therapeutics.
Viet Dang ’18 works in the lab at Adaptive Phage Therapeutics. (Courtesy of Bri’Anna Horne ’17)

Beyond learning how to employ common lab techniques used in genetics work, the Phage Hunters students are learning how to ask the right questions, take risks, and troubleshoot: They’re becoming scientists.

“I am convinced that the best thing about the SEA-PHAGES program is the ownership aspect of it,” Caruso says. “The students have to be allowed to carry out their own experiments and fix their own problems. You’re there to help them when they fail, but they have to be allowed to fail.”

One day in the lab stands out for Kawa—a six-hour stretch where she was so captivated by the research, she just kept on working. “It was the happiest day thus far in my college career,” she remembers. “At that point I had thought I wanted to become a researcher and go into biotech, but that day my mind was totally made up, 100 percent. This is what I want to do.”

Collaboration on the cutting edge

With five UMBC alumni at Adaptive Phage Therapeutics, which has a total staff of fewer than 20, “Our UMBC family mentality translated directly into our APT family,” shares Bri’Anna Horne ’17, biological sciences. “Because it’s so small, we work together, and we support each other for every single procedure we’re doing…It’s really great to have a team that you already have a working history with in a professional setting.”

The work itself is as rewarding as the atmosphere. “All the techniques we learned in Phage Hunters directly translate to the work we do in the lab on a daily basis,” says Kawa. And executing those techniques is saving lives. APT is working with the U.S. Navy to create a “phage bank” that can speed up the process of finding phages that can treat antibiotic-resistant bacterial infections in patients who have run out of other options.

“It’s exciting for us, because we’re doing cutting-edge research, and we’re actually saving people’s lives,” says Horne.

Dang feels similarly. “Being on the cutting edge of biotech is really exciting… Just being right there, potentially changing history, is really exciting.”

For Joseph Tewell ’17, biological sciences, the work at APT is more personal. “I got more interested in phages because I’m part Filipino and there are a lot of issues with [access to] medicine in the Philippines,” he shares. “I thought phage therapy might be an interesting way to try to expand medical access in developing countries.”

Joe Tewell '17 uses a chemical hood at Adaptive Phage Therapeutics.
Joe Tewell ’17 uses a chemical hood at Adaptive Phage Therapeutics. (Courtesy of Bri’Anna Horne ’17)
Cool connections

The success of these alumni has resulted in a strong connection between the Phage Hunters program at UMBC and other local biotech companies as well. For example, Julie Norton ’15, biological sciences, M.S. ’16, applied molecular biology, works at Intralytix on Baltimore’s Inner Harbor.

Erill first invited Intralytix staff to give a guest lecture for the Phage Hunters students in 2015. Today, Intralytix and APT both regularly guest lecture and advertise job openings to current students involved with Phage Hunters. Current UMBC alumni employees serve as unofficial recruiters, too.

When she meets with current students in the program, Horne highlights both the career opportunities she’s found in biotech, and the broader range of possibilities in the field. “I really love what I’m doing now,” she says. And that feeling is even more meaningful for Horne knowing that as a highly skilled professional in such a quickly growing technical field, there are now “so many options to explore.”

Learning from Ellicott City

In the aftermath of two “1000-year” floods in three years, can experts, officials, and residents agree on a way to prevent the next big one while preserving this historic town?

By Sarah Hansen M.S. ’15

Ellicott City, Maryland, rests in a steep, narrow valley at the confluence of the Tiber River, its smaller unnamed tributaries, and the much larger Patapsco River. All that water power made it the perfect place to build a mill town—as brothers Jonathan and George Ellicott did beginning in 1772.

The mill town flourished in the 1800s and was the first stop on the Baltimore and Ohio Main Line railroad (the first railroad in the United States) beginning in 1831. Housing and shops quickly sprang up along the winding street to service residents and visitors.

Today, Wilkins Rogers Mills still processes flours and cornmeal on the old site, and the B&O rail station at Ellicott City is the oldest surviving rail station in the United States. It was designated a National Historical Landmark in 1968, and the Main Street area, which retains over 200 historic buildings, was listed on the National Register of Historic Places in 1978.

But while much has stayed the same, much has also changed since Ellicott Mills’ 19th-century heyday. Rather than workaday folk gathering sundries on Main Street, droves of tourists and preservation enthusiasts now stroll the charming byway to patronize boutique shops and cafés.

Or, they used to.

Main Street in Ellicott City is seen from above the day after a flash flood devastated the historic city on the Patapsco River. Photo: Jerry Jackson, permission from Baltimore Sun Media. All rights reserved.

In 2016, and then, extraordinarily, again in the spring of 2018, Historic Ellicott City was ravaged by flash floods that trapped diners in restaurants’ upper stories, saw empty cars and trucks careening down Main Street, destroyed homes and businesses, left debris for miles downstream, and, in total, took three lives.

The events, both dubbed “1000-year floods” in the media, have left residents and business owners with the tough decision to stay or go. The Howard County government is faced with a dilemma, too: Ellicott City is a popular attraction and has been an economic powerhouse in the county for decades. But when storms come, as they inevitably do, it becomes very dangerous, very quickly.

The floods are changing

“Ellicott City was put there for a reason, to take advantage of water power,” says Andrew Miller, professor of geography and environmental systems. “Therefore, nobody should be surprised that water power is a potential hazard.”

Faculty in UMBC’s geography and environmental systems (GES) department have been studying the local watershed for years. Miller has a particular interest in the role floods play in shaping stream channels and the local ecosystem. Matthew Baker studies watershed ecology and has been deeply involved with the removal of a dam just downstream from Ellicott City. Jeffrey Halverson is a regular contributor to The Washington Post, where he explains the mechanics of regional storm systems for the general public.

Miller says the dam project and flooding studies provide unique opportunities to study aspects of stream ecology, such as sediment movement, from interesting angles. “It’s very rare to have a research project that falls into your lap that’s two miles from your office,” he says, “and to have multiple research projects within two miles of your office intersect with each other is even more unusual.”

Flooding in Ellicott City is nothing new. One of the worst floods was in 1972, when Hurricane Agnes caused the Patapsco River to overflow its banks by 14.5 feet and fill the lower end of Ellicott City’s Main Street. This was a flood “from the bottom up,” explains Halverson. Most of the town’s previous flooding events have happened in a similar fashion—a massive rainfall event deluges the entire region, and the river slowly rises until it can no longer contain the water. Crucially, residents have plenty of time to evacuate in these storms.

Flood waters on Main Street in Ellicott City, 1972. Photo from the Howard County Historical Society.

But the 2016 and 2018 floods were different. Rather than heavy rain everywhere over an extended period, forecasters predicted potentially devastating, shorter-term rainfall at a hyper-local level in both storms. “But there was never any attempt to localize the storm down to the county or sub-county level,” wrote Halverson for Weatherwise. Why? “Our ability to do so is practically non-existent.”

As a result, when the deluges hit Ellicott City in 2016 and 2018, “people barely had time to get to the second floor of the restaurant,” Miller says.

[rara_call_to_action title=”” button_text=”Read More” button_url=”https://umbc.edu/a-timeline-of-resilience-in-flood-prone-town/” target=”_blank” button_align=”center”]A Brief History of Major Ellicott City Floods[/rara_call_to_action]

“It’s not just the rain that makes a flash flood, it’s also the terrain and the nature of the landscape,” Halverson wrote. Considering this, other changes since the 19th century come into play. Ellicott City has become a highly desirable place to live, and suburban development now sprawls in all directions from Main Street.

Development means more impervious surfaces—roads, rooftops, driveways, patios—and impervious surfaces make it harder for a landscape to absorb rainfall. So, in the 2018 flood, when the center of the storm was a bit upstream from Ellicott City, Halverson wrote, “the torrent of stormwater runoff cascaded downslope into the topographic bowl of the town, flooding it from the top down.”

The floods are “an example of effectively a small tributary watershed ‘wagging the dog,’ making the entire Patapsco River flood before the rest of the drainage area contributed,” says Baker.

In both floods, “upslope development undoubtedly made things worse,” Miller says, but isn’t fully to blame. These events “would have exceeded any kind of storm water management that you could have put in,” he says.

Because of the way heavy rainfall on a small section of the watershed can cause severe flash flood events, Baker says, “the Patapsco River is now behaving much more like an urban river…than its general land use would suggest.” Why is less clear. It could be increasing development, or it could be changes in rainfall patterns influenced by climate change. More likely, it’s a combination of both as well as other factors.

What to do?

The local government is grappling with what to do with this beloved—and sometimes deadly—section of town. They commissioned the McCormick Taylor Report to provide a menu of options that could keep the town safe in future events similar to 2016 and 2018 while keeping the town as-is. The recommendations included $35 million in immediate improvements, plus $60 to $85 million more for longer-term projects. It’s hard to imagine anyone being willing to spend that much to protect such a small parcel of property. The plans included everything from “pipe farms” underground to store storm water until it could be released more slowly, to tunneling through bedrock to create a pathway for water through town that wouldn’t disturb the street above.

In September 2018, the county government announced a plan that would involve removing up to 10 of the historic buildings to take people out of harm’s way and improve water flow for the next major flood. The public outcry was swift and powerful, and no demolition has occurred.

[rara_call_to_action title=”” button_text=”Read More” button_url=”https://umbc.edu/an-ounce-of-prevention/” target=”_blank” button_align=”center”]UMBC Experts Discuss Preventing Future Floods[/rara_call_to_action]

Most UMBC scientists prefer not to engage in local politics, but based on their work, they can inform conversations on what the county should consider as they’re making decisions. In the days immediately following both storms, Miller and Halverson were in high demand with the news media. One question that kept coming up was whether another storm of this strength could happen again, and when.

Miller is currently working on a paper using evidence to make the case that “it’s an extraordinary event, but it’s not as extraordinary as we think it is. There’s some evidence, although right now it’s not completely conclusive, that we are seeing greater frequency of large floods,” says Miller. “So you cannot assume something like this just won’t happen again.”

Parts of Main Street are returning to life in summer 2019. Many stores remained shuttered. Photo by Marlayna Demond '11.

In its current state, “There’s not enough room for Main Street and the river—that’s why the river flows underneath,” explains Miller. “It’s a pipe dream that you can just make this problem go away.” In fact, dealing with the danger of water is a challenge that will only get worse as climate change leads to more strong storms and rising seas. “This is a microcosm of the much bigger problem that we face on a massive scale in this century,” Miller says.

As a local and a hydrologist, Baker sees both sides of the argument. “I appreciate the historic nature of the community, and I think something would be lost if they tore all those buildings down. At the same time, I can understand why any administrator would want to minimize the risk of loss of life, so that’s totally reasonable as well,” Baker says. “I don’t think there’s a real clear solution here, it’s just a value judgment that people have to decide what is most important in this situation.”

And so, the debate rages on. In the meantime, visitors continue to stroll, shop, and snack at the bright and cheery storefronts along Main Street, albeit in reduced numbers. Some establishments, however, remain shuttered, and storm damage is still visible through dirty windows. The contrast reinforces the fragility of this charming historic oasis, reminding tourists, scientists, and public administrators alike what happened here, and what could happen again.

How the community chooses to proceed is still uncertain, but one hopes the expertise of elected officials, scientists, and the public will all be brought to bear in a way that keeps people safe and allows Ellicott City—in whatever form it eventually takes—to thrive for years to come.

****

Header photo by Mark Baxter @SkySightVIP

CNMS celebrates a year of growth in partnerships to support student success

When Bill LaCourse became dean of UMBC’s College of Natural and Mathematical Sciences (CNMS) in 2012, he had three top priorities in mind: innovate undergraduate science education to boost learning outcomes, forge new partnerships, and develop and support a diverse group of faculty. This year, the college took several steps forward in realizing this vision.

“The college has laid the foundation, and now is really in a strong position for growth,” LaCourse says. “It’s all about paying attention to the people and their needs,” he explains, so faculty, staff, and students can do their best work and create a thriving community together.

Student success at the center

This year, CNMS received a $1.4 million grant from the National Science Foundation for Improving Undergraduate Science Education. Faculty at UMBC and community college partners will use the funding to improve the undergraduate experience in biology—the major of one in six UMBC students. This includes focus areas like enhancing the alignment of curriculum across institutions and making sure advising meets the needs of transfer students, both before and after they come to UMBC.

The CNMS Active Science Teaching and Learning Environment (CASTLE) is a classroom designed for team-based instruction. It has tables to facilitate group work, devices set up for screen sharing with large screens at the front and back of the room, and walls covered with whiteboards.

“We’re building community, trust, and relationships with the community colleges,” LaCourse says, and that has huge benefits for students.

The Active Learning Inquiry Teaching (ALIT) certificate offered to UMBC STEM faculty is another growing partnership focused on supporting students. It includes CNMS, the College of Engineering and Information Technology, the Faculty Development Center, and CNMS’s Building Infrastructure Leading to Diversity (BUILD) program. To earn the ALIT certificate, faculty attend a series of workshops on teaching in an active learning style, which has been shown to more effectively engage students and boost performance. They also participate in a teaching observation and other activities.

Initiatives like the Science and Mathematics Advising Resource Team (SMART) are also coming into full swing now. “The program formalizes the relationship between pre-professional advisors, CNMS advisors, and faculty advisors,” explains SMART director Michelle Bulger. “Everyone knows a little about everything,” so no matter which resource they start with, students get the support they need to find their best path through UMBC and into a career.

Celebrating student pioneers

The UMBC STEM BUILD program reached an exciting milestone this academic year: graduating its first program participant, Alexis Waller, in December 2018. Additional BUILD students earned their degrees in May 2019.

BUILD Trainees Ashley Majekodunmi ’21 (center left) and Avantika Krishna ’21 (center right) work in the lab with their faculty mentor, Weihong Lin (right).

BUILD is a CNMS initiative funded by the National Institutes of Health. It is designed to help UMBC learn best practices for engaging large numbers of students in mentored research and other practices that support student success in STEM. At some institutions, mentored research experiences are reserved for a select few, often in scholars programs. At UMBC, faculty and staff are actively working to make research accessible to all students.

Three students just became the first to complete another new path through UMBC. Just one day after graduating from UMBC, they were commissioned as officers in the U.S. military. CNMS administers UMBC’s Naval science department, which supports the Naval Reserve Officer Training Corps (NROTC) program. UMBC’s NROTC program was the first of its kind in Maryland when it was launched in 2015.

This spring, ENS Ghazi Nazzal ’19, business technology administration, and ENS Ryan Simpson ’19, environmental science, were commissioned as officers in the U.S. Navy. 2nd Lt Benjamin Dunlap, modern languages, linguistics, and intercultural communication, was commissioned as an officer in the U.S. Marine Corps.

“We’re proud to have them on campus,” says LaCourse, who has a family history of Navy service.

Ghazi Nazzal ’19 (right) assists another midshipman in using UMBC’s state-of-the-art virtual reality naval training system.

Connecting every angle

One of the most exciting CNMS partnerships emerging this year—with the potential to significantly impact students and employers in the region—has a complex name: the Translational Life Science Technology (TLST) program. The program focuses on preparing UMBC students at the Universities at Shady Grove for careers in Montgomery County’s rapidly growing biotech industry. TLST is UMBC’s first undergraduate STEM program at Shady Grove, and this year welcomed its first students.

With this program as well as the professional master’s degree in biotechnology, CNMS is pioneering UMBC’s expansion at the Shady Grove campus to serve the over one million people in Montgomery County,” says Annica Wayman ’99, M6, mechanical engineering, the new associate dean for Shady Grove affairs for CNMS.

Dean Bill LaCourse (left), Annica Wayman ’99 (right), and some of the first students in the TLST program.

LaCourse sees the new program as the beginning of “a new way of working with Shady Grove.” He shares, “It puts us in a position to bring applied STEM programs to the doorstep of businesses in Montgomery County.”

Constructing collaboration

Perhaps the most visible representation of the college’s commitment to forging partnerships is the Interdisciplinary Life Sciences Building (ILSB), now in the final phases of construction. It will open for classes in fall 2019.

The building includes spacious and bright teaching labs, open faculty laboratory space that promotes collaboration, and classrooms designed for active teaching and learning. Unlike other buildings on campus, faculty who wish to conduct research in the ILSB must propose interdisciplinary projects to be completed there, and the lab spaces are designed to facilitate a variety of kinds of work equally well, from genetics to environmental engineering.

An artist’s rendering of the completed Interdisciplinary Life Sciences Building.

The new building will also house UMBC’s second Maryland Public Art installation: a colorful sculpture that emerges from a large wall and features abstractions of elements found in UMBC research, from bird flight to microscope images of individual cells.

The ILSB is open for use by any department on campus, and is administered by CNMS. “It’s exciting for me to be involved in the operations of the ILSB,” says building manager Dennis Cuddy. “It will be a transformative facility and allow UMBC scientists and students to do important work and cutting edge research in a flexible, state-of-the-art facility.”

Josh Wilhide, manager of UMBC’s Molecular Characterization and Analysis Complex, is particularly excited about new research equipment in the ILSB. One instrument will streamline the process of generating information about the proteins in a sample. It will be “used for drug discovery and genetic exploration for researchers ranging in fields from chemistry to biology to engineering,” Wilhide says. “The ILSB truly is a building designed to drive multi-discipline research.”

Faculty forward

CNMS has also made significant structural changes in the last year to better recruit and support a diverse faculty, and to enhance advancement opportunities and research support for faculty at every level. In addition to Wayman’s new role as associate dean, Kathleen Hoffman, professor of mathematics, now also serves as the CNMS associate dean for faculty advancement. Chuck Bieberich, professor of biological sciences, serves as the associate dean for research.

CNMS Associate Dean for Research Chuck Bieberich

“Our college has a strong history of performing cutting-edge research. However, in recent years, the federal funding climate has created new challenges for even the most seasoned researchers,” Bieberich says. “So one dimension of my role as associate dean is to connect our faculty, both newly hired and long-serving, with resources that can increase the likelihood of funding success.”

Hoffman has been supporting faculty advancement, particularly for women in science, for years. She was a key player in developing UMBC’s ADVANCE program, an initiative funded by an NSF Institutional Transformation Grant in 2003 that has led to a 60 percent increase in the number of women faculty in STEM. At a more granular level, ADVANCE has led to a 75 percent increase in women at the associate professor level and a 140 percent increase at full professor.

CNMS Associate Dean for Faculty Advancement Kathleen Hoffman

As of fall 2018, 24 percent of faculty in STEM at UMBC are women, which shows both how much progress has been made and how much growth is still needed.

“In this position, I will support CNMS faculty through college-wide workshops and initiatives focused on faculty success,” Hoffman says. She adds that she and Bieberich “will ensure that CNMS faculty have the support they need to fulfill their potential as faculty members in their departments, in the college, and as members of the university community.

Diversity drives success

This year, CNMS hired two more pre-professoriate fellows. The fellows program is designed to enhance the diversity of CNMS faculty to better reflect the college’s diverse student body and actively welcome faculty who prioritize the value of diversity. Adriana Lima will join physics, and Joseph Bennett will join chemistry and biochemistry.

The biological sciences department led the way with this program, having previously hired Fernando Vonhoff and assistant professor Mercedes Burns. Mathematics and statistics followed with the hire of Yehenew Kifle, who had previously spent a year at UMBC as a visiting professor. Vonhoff and Kifle will successfully convert to assistant professors in August 2019.

Arachnologist and evolutionary biologist Mercedes Burns (right) and her postdoc, Sarah Stellwagen, transfer a harvestman (commonly known as daddy-long-legs) between them.

“We want to make sure that UMBC can be a good home for faculty from all backgrounds,” says LaCourse. The pre-professoriate program offers incoming faculty two-year appointments as research assistant professors, with structured mentoring and other scaffolds for success. There is the option to convert the fellowship to an assistant professor position.

This year UMBC also partnered in the launch of the PROMISE Academy. This new initiative will draw on the expertise of universities around the nation and evidence-based best practices to recruit and retain a diverse group of faculty members in STEM fields.

With the 15th anniversary of its formation just one year away, “CNMS is coming into its own,” LaCourse says. “We’re ready to move to the next level.”

Banner image: CNMS pre-professoriate fellow Fernando Vonhoff works in the lab with Abby Cruz ’18.

All photos by Marlayna Demond ’11 for UMBC unless otherwise noted.

UMBC’s Jeff Leips receives NIH grant to explore how genes affect immune system function as we age

As we age, our immune systems don’t work as well as they did when we were younger. That phenomenon is called immunosenescence, and it’s not exclusive to humans. The decline of the immune system with age has been found in every organism scientists have tested. But why does it happen? And why do some individuals age more quickly than others? While factors like our diet, exercise level, and the air and water quality where we live play a role in our long-term health, so do our genetics, says UMBC’s Jeff Leips.

With funding from a new National Institutes of Health grant, Leips, professor of biological sciences, is on a mission to identify genes that play a role in the decreasing efficacy of the immune system with age. The fourth-leading cause of hospitalization among the elderly is an infection that their immune system can’t handle on its own, Leips says, and being hospitalized poses its own risks, “so it’s a big problem.”

Leips’s lab uses Drosophila, or fruit flies, to study the genetic basis of aging across a range of traits, from immune system function to walking speed, endurance, and strength. While it may seem strange to use an organism so different from us, “We know many aspects of the innate immune system in Drosophila—a lot of the signaling pathways—are conserved between flies and humans,” he explains. “So the idea would be to identify candidate genes that we could then test for their effects on human immunosenescence.”

The grant will allow Leips and his team of students to compare how quickly 200 different strains of flies, each with a unique genetic makeup, can clear an identical infection. Within each strain, the lab will test at least 20 flies of different ages. All the strains they’ll use have already had their entire genome sequenced, so “we can associate differences at the DNA level with differences in their ability to clear infection,” Leips explains.

With the extensive sequencing and ease of raising flies in the lab, “If you want to know something about basic biology, in an aging context, there’s arguably no species that’s this good.”

Focusing on the first step

Vertebrates, including humans, have a two-stage immune response: innate and adaptive. The adaptive system is the one that “remembers” being infected with a disease, which is what makes vaccines work. Leips is focusing on the innate response, which researchers know less about. The two systems interact in vertebrates, but flies only have an innate system.

“In invertebrates, we can look at effects on the innate system without the complications of the adaptive component feeding back into it,” Leips says. “It’s a simpler system, and maybe more useful.”

The innate immune system also comes in two stages. In the first stage, circulating blood cells engulf bacteria or other invaders and destroy them. If needed, the organism’s innate immune system activates stage two and deploys antimicrobial proteins to tackle the problem. Leips will focus specifically on the first stage, called phagocytosis, “because that’s the first thing that happens,” Leips says. “It’s only if that system is overwhelmed that the antimicrobial proteins respond.”

A tricky technique

Leips and Michelle Starz-Gaiano, associate professor of biological sciences, worked together to develop an imaging technique that allows them to count the number of bacteria swallowed by a fly’s blood cells. Using this method, “We can compare the ability of different genotypes to engulf bacteria across different ages,” Leips explains.

When they found that older flies had more bacteria in their cells, it came as a surprise. But even phagocytosis has multiple stages: the cells must swallow the bacteria, and then digest them. When Leips and Starz-Gaiano injected the flies with microscopic, non-digestible beads, they found that old and young flies had the same number of beads in their cells.

“We think the reason the old cells have many more bacteria in them is because the bacteria are accumulating in the cells, but not being processed,” Leips says. As part of the new grant, they’ll look at genes that might affect how the bacteria are trafficked into the cell and how it digests them.

Thinking big

This work is one of many projects in Leips’s lab. Another involves collaborating with Peter Abadir at Johns Hopkins University to see how flies with different genetic material respond to human medications for high blood pressure.

There’s evidence that some human patients (but, notably, not all) experience improved strength and endurance on these medications in addition to lower blood pressure. Leips and his colleague would like to know if differences in how people respond to these medications are genetically driven. If so, the findings could lead to more precise personalized medicine.

“We’d like to be able to identify genes that would predict if you’re going to respond in a positive, negative, or neutral way to a drug,” Leips says. “We’ve gotten some really cool results.” They found that flies respond to the drug even though they don’t have a circulatory system. They do have the same genes that the drug targets, he says, “which means effects of the drug on these traits might be through some other mechanism.”

With his new NIH grant, Leips says, “Ideally, I want to understand the mechanisms—what goes wrong with age and immunity? Once we know that, the next question is whether we can find ways to try to ameliorate the effects of aging on those traits.”

Leips hopes the research will provide data that will fuel future work on aging and immunity with implications for human health. “Getting sick is one of the worst things that happens to people,” he says. “So if you can minimize that when you’re old, it’s going to improve your quality of life. And that’s really what the lab is all about.”

Banner image: Jeff Leips works in the lab with students at UMBC for summer research through the UMBC STEM BUILD program. From left to right: Moriah Thompson, Anne Arundel Community College; Teiona Sanders, Morgan State University; and Bolutife Baiyewu, Morgan State University. 

All photos by Marlayna Demond ’11 for UMBC.

UMBC’s Hua Lu works to decode plant defense system, with an eye on improving farming and medicine

UMBC’s Hua Lu, professor of biological sciences, and colleagues have found new genetic links between a plant’s circadian rhythm (essentially, an internal clock) and its ability to fend off  diseases and pests. The findings were 10 years in the making and published in Nature Communications this week. The results could eventually lead to plants that are more resistant to disease-causing pathogens and better treatment for human diseases.

“It’s quite cool,” Lu says, “because, in both plants and animals, people are beginning to study the crosstalk between the circadian clock and the immunity system.”

Timing is everything

In response to daily attacks from bacteria, fungi, and other pests, plants have evolved various strategies to protect themselves. Plants may close their stomatasmall openings in the waxy coating on their leavesto prevent entry by some bacteria. They might produce chemicals such as salicylic acid and  jasmonic acid to repel bacteria and insects. They also make a large number of proteins that are important for successful defense.  

Actions like closing stomata, producing salicylic acid, and more happen on a daily schedule, often peaking at the times when certain pathogens and pests are most likely to be active. The rhythmic nature of plant defense suggests plants are coordinating their internal clock with their defense system to increase the effectiveness of their defensive actions.

In this study, Lu and colleagues found for the first time that LUX, a central gene in the plant circadian clock, is important for regulating the opening and closing of the stomata at specific times of day, and also for activating defense mediated by salicylic acid and jasmonic acid.

In a typical plant, the stomata open during the day, to enable exchange of gases required for photosynthesis. Then they close at night, to prevent water loss. The stomata also close in response to daytime pathogen attacks. They respond minimally to an attack at night, because they’re already closed.

However, in plants with a non-functional version of the LUX gene, Lu found that the stomata are open both day and night. During a daytime attack, the stomata stay open wider than normal plants. During a  nighttime attack, though, some of the stomata close. This means that plants lacking a functional LUX gene have less control over when their stomata open, allowing more opportunistic pathogens to get in. This distinction indicates that LUX is critical for the timing of the stomata-driven defense response, tying defense to the circadian clock in a new way.

Lu’s research also dives into the relationship between the LUX gene and the defense chemicals salicylic acid and jasmonic acid. While it was known that the circadian clock can regulate defense responses, this paper shows that the reverse is also true: “A properly tuned circadian clock is important for defense activation. When defense is activated, it then can feed back to regulate the circadian clock,” Lu says.

The research team specifically showed that the presence of LUX is needed for normal jasmonic acid signaling. In turn, jasmonic acid also affects expression of LUX and the circadian clock. This reciprocal regulation between the circadian clock and defense signaling helps plants balance their energy use for normal growth and development and defense responses.

From farms to pharma

Lu is interested in pursuing further research to figure out how timing influences the plant defense system. How does the circadian clock affect multiple aspects of defense responses? What molecules from pathogens and pests interfere with a plant’s circadian clock and subsequently limit its ability to protect itself? Better understanding how clock genes control plant defense and how pathogens interact with plant defense systems could benefit agriculture and beyond.

“Pathogens are everywhere all the time. Often the most active form of a pathogen varies during a day. Also, plants could have different defense strategies at different times of day,” explains Lu. “So, when is the best time to apply pesticides? That could depend on the pathogen, its infection mode, and the behavior of your crop plants. I think that field tests are needed to figure out the best time to apply chemicals to achieve the most efficacy in preventing infection or the spread of infection.”

Less pesticide use overall would reduce runoff of chemicals into waterways and lower costs for farmers. Reduced use of antibiotics could help stem antibiotic resistance, which would benefit humans, too.

Plus, plants aren’t the only ones whose immune system activity fluctuates throughout the day. Animal systems also have daily cycles. So, “similar ideas can be applied to the medical field,” Lu says.

There are similarities between the ways plants and animals interact with their pathogens and pests at the molecular level.  Maybe in the future, your prescription will come with specific timing instructions, or your surgery will be scheduled based on your immune system activity.

Science in action

Lu says all of her research, and this multi-part paper in particular, is driven by her lab members. “It’s great to work with this many dedicated people,” she says. “Without them, I couldn’t do it.”

That includes postdoctoral fellow Chong Zhang, who is now employed by the USDA, and current postdoc Min Gao, who are co-first authors on the new paper. Five undergraduate students and a high school student also contributed to this long-term project. Some of the experiments required testing every four hours over a 24-hour period, which meant someone was sleeping on a couch in the lab when they were underway.

Overall, Lu’s team members are driven by the potential benefits their work could contribute to society. They are excited by the prospect of improving crop yields to feed a growing population, reducing  pollution, or reducing side effects for human medical treatment through improved timing and dosing.

“This field interests me because I can see my work have some practical applications, and I think that’s important,” Lu says. “That should be every scientist’s goal—to use your knowledge in real life.”

Banner image: Jessica Allison, a graduate student in Hua Lu’s lab (left); Linda Wiratan ’19 (center); and Hua Lu. Photos by Marlayna Demond ’11 for UMBC.

UMBC’s Sarah Stellwagen first in world to sequence genes for spider glue

Today in Genes, Genomes, Genetics, UMBC postdoctoral fellow Sarah Stellwagen and co-author Rebecca Renberg at the Army Research Lab published the first-ever complete sequences of two genes that allow spiders to produce glue—a sticky, modified version of spider silk that keeps a spider’s prey stuck in its web.
The innovative method they employed could pave the way for others to sequence more silk and glue genes, which are challenging to sequence because of their length and repetitive structure. Better understanding of these genes could move scientists closer to the next big advance in biomaterials.

Sticky solutions

Spider silk is what spider webs are made of, and it’s been touted for years as the next big thing in biomaterials because of its unusual tensile strength combined with its flexibility. There are more than 45,000 known species of spiders, each of which makes between one and seven types of silk. However, despite many partial sequences, less is known about the full genetic structure of spider silk: Only about 20 complete genes have been sequenced. “Twenty pales in comparison to what’s out there,” Stellwagen says.
Plus, spider silk has proven tough to produce in large amounts. Spiders convert liquid blobs of silk into solid, spindly fibers in a complex process inside their bodies. Scientists can make the liquid, but “we can’t replicate the process of going from liquid to solid on a large industrial scale,” Stellwagen says.

Sarah Stellwagen with her pet baby orange-kneed tarantula.
Sarah Stellwagen with her pet baby orange-kneed tarantula.

Spider glue, however, is a liquid both inside and outside the spider. While the glue “does have its own challenges,” Stellwagen says, that difference might make spider glue easier to produce in a lab than silk.
Stellwagen sees great potential for spider glue applications as organic pest control. After all, she says, “This stuff evolved to capture insect prey.”
For example, farmers could spray the glue along a barn wall to protect their livestock from insects that bite or cause disease, and then could rinse it off without worrying about polluting waterways with dangerous pesticides. They could use glue similarly to protect crops from pests. It could also be applied in areas where mosquito-borne illnesses are prevalent. “It could also just be fun to play with,” Stellwagen says.

A “behemoth of a gene”

Before Stellwagen and Renberg’s work, which was funded by the Army Research Lab, the longest silk gene sequenced was about 20,000 base pairs. When she started this project, Stellwagen was expecting to sequence the glue genes quickly and then move on, building on what she learned from the sequence. Instead, it took her and Renberg two years just to finalize the sequence.

Ph.D. student Tyler Brown and his (and Stellwagen's) advisor Mercedes Burns, assistant professor of biological sciences, conduct genetic testing on harvestmen DNA. Harvestmen (often called "daddy-long-legs") are close relatives of spiders.
Ph.D. student Tyler Brown and his (and Stellwagen’s) advisor Mercedes Burns, assistant professor of biological sciences, conduct genetic testing on harvestmen DNA. Harvestmen (often called “daddy-long-legs”) are close relatives of spiders.

“It ended up being this behemoth of a gene that’s more than twice as large as the previous largest silk gene,” Stellwagen says. It was a long, hard road to the day she found Renberg in the lab and said, “I think our gene is 42,000 bases long. I think we finished it.” And in the end, it was taking a risk on a cutting-edge technique that finally yielded the complete sequence.
Not only was the gene exceptionally long, but, like spider silk genes, it has many repetitions of the same sequence of bases—A, T, G, and C—in the middle. Modern sequencing techniques (called “next generation sequencing”) work by generating DNA sequences for all of an organism’s genes, but chopped up in little pieces. Then, like solving a puzzle, scientists must match up the overlapping ends of the short sections to determine the entire sequence.
However, if your gene is repetitive, you need a single sequence, or “read,” that extends from before the repetitious region to beyond the end to know how many repetitions there are. If your repetitious section is long, as it is in the glue genes Stellwagen and Renberg studied, the chance that you would get the read you need with next-generation methods is slim.

Sarah Stellwagen discusses spider biology with Tyler Montgomery '20, biochemistry and biological sciences, and Genevieve Ahearn '19, biological sciences and environmental science.
Sarah Stellwagen discusses spider biology with Tyler Montgomery ’20, biochemistry and biological sciences, and Genevieve Ahearn ’19, biological sciences and environmental science.

Fortunately, “third-generation” sequencing techniques are now available. Third-generation sequencing produces longer reads, but fewer of them. Only by repeating the experiment several times do you have a chance of getting the reads you need to determine the number of repetitions and finally define the gene’s entire sequence. “It’s challenging,” says Stellwagen. “You’re picking a needle from a haystack.”
But it worked. After two years of going to the computer and not seeing positive results, Stellwagen and Renberg finally got the reads they needed to define the entire gene’s sequence.
Stellwagen is already thinking ahead to what comes next. “Now that we have a protocol for discovering full-length silk genes, what do silks from other species look like?” she asks.
“I’m super excited that I was able to finally figure out the puzzle, because it was just so hard,” Stellwagen says. While it was a much bigger challenge than she expected, “Ultimately we learned a lot, and I am happy to put that out there for the next person who is trying to solve some ridiculous gene.”
Banner image: Sarah Stellwagen (left) and her postdoctoral advisor Mercedes Burns work together in the lab. All photos by Marlayna Demond ’11 for UMBC.
Read the complete article in G3: Genes, Genomes, Genetics.

The Family Connection: Paying it Forward

“To whom much is given, much is required.” Meyerhoff scholars internalize this message, which is introduced during Summer Bridge and is almost as ubiquitous as “Focus, Focus, Focus,” and Langston Hughes’ “Dreams” at Meyerhoff gatherings. For many of the scholars, giving back has become a foundational principle in their lives, as they mentor colleagues, students, and interns in their roles as researchers, medical professionals, biotech entrepreneurs, and more.

This extension of the Meyerhoff program beyond UMBC amplifies its impact. Like a family tree, the DNA for the Meyerhoff program’s values and practices travels through generations of researchers as scholars graduate from UMBC and carry their experiences with the program wherever they go, cultivating the Meyerhoff culture in their new environments. Perhaps no simile is required—members of the Meyerhoff community feel that it is, indeed, a family.

“We truly are a family, full of people who accept and love each other as we are,” says Rhea Brooking-Dixon ’02, M10, biological sciences. After UMBC, she earned her Ph.D. from Duke University in experimental pathology, and today she is a scientist at Booz Allen Hamilton. She is married to Jason Dixon ’02, M10, computer engineering, so for them, Meyerhoff means family in multiple ways.

Families always help each other out, and that stuck with Dixon and Brooking-Dixon after graduation. They remember being asked by advisors at UMBC about participation in a study group, both to receive and give support to their classmates. “That showed us that the Meyerhoff Scholars Program wanted us to consider not just what a community could do for us,” they share, “but what we could also do for our community, whatever the scale, to help everyone develop into their best selves.”

Cultivating each Meyerhoff cohort as a family begins with Summer Bridge, a six-week experience that combines academics and social activities. Students learn together, eat together, and play together, forming bonds that buoy them through their years at UMBC and beyond.

“We’re developing a community. So to generate this concept of a community, they’ve got to have a shared experience,” says Keith Harmon, director of the Meyerhoff Scholars Program. “So a big part of Bridge is doing everything together. You do nothing in Bridge as an individual.”

The mentality of giving back and supporting one’s community has been inherent to the program since its early days. Crystal Watkins-Johansson ’95, M3, biological sciences, earned her M.D./Ph.D. at Johns Hopkins University and now serves as director of the memory clinic in the neuropsychiatry program in the Sheppard Pratt Health System, and as an assistant professor of psychiatry at the Johns Hopkins School of Medicine.

“When we recruit, we don’t talk a lot about Ph.D.s and M.D./Ph.D.s. We talk about legacy,
and we talk about service. We talk about leadership. We talk about being a part of
something that’s bigger than yourself.”
– Keith Harmon, Director, Meyerhoff Scholars Program

“As a graduate of the Meyerhoff Scholars Program at UMBC, I have developed a tradition of mentoring undergraduate and graduate students from the Meyerhoff program,” Watkins-Johansson says, “as the mentoring I received through the program continues to be the foundation of my success.”

Isaac Newton said, “I have only seen farther by standing on the shoulders of giants,” and that phrase, too, has resonated with Meyerhoff Scholars. Erwin Cabrera ’10, M18, biological sciences, shares, “The Meyerhoff staff, program alumni, and UMBC faculty were my giants, so I strive to be a giant for those students who come after me.”

Cabrera’s current role aligns directly with his commitment to mentoring the next generation of biomedical professionals. After earning his Ph.D. at the New York University School of Medicine, he now serves as the associate director for the Research Aligned Mentorship program at Farmingdale State University, a program that provides additional supports—similar in ways to the Meyerhoff Scholars Program—to annual cohorts of Farmingdale students.

For some Meyerhoff scholars, it was the group experience that helped them see their true potential. “Being surrounded by a critical mass of high-achieving African Americans was extremely important to my growth as an individual,” says Kamili (Shaw) Jackson ’97, M5, M.S. ’99, mechanical engineering. “It gave me confidence and humility at the same time.”

Mentoring the next generation of scientists and engineers, and changing their lives in the process, is a worthy goal and a laudable outcome of the Meyerhoff Scholars Program. But the ripple effect goes even farther. Those researchers, many of whom are from underrepresented groups in STEM, bring fresh perspectives and energy to their work, and the results of their efforts can impact an even larger set of people.

“My research experience in Dr. [Michael] Summers’ lab helped me recognize the lasting impact that biomedical research could have on the lives of patients,” shares Chelsea Pinnix ’99, M7, biochemistry and molecular biology. “I began to envision myself as more than a future physician, and instead as a young woman with the potential to heal patients in my clinic and improve medical care for patients that I would never meet through meaningful research.”

As the Meyerhoff Scholars Program enters its fourth decade, the emphasis on paying it forward is just as strong as it was at the program’s founding in 1989. Except now, there already exists a network—a family—of hundreds of Meyerhoff alumni ready to support upcoming students in all that they wish to pursue, which goes far beyond earning a degree (or three).

And that message of changing the world is part of the conversation from the start. Teaching students to think beyond the degree toward thinking about a career where they can make real change in the world, both by doing meaningful research and mentoring others, is an important part of the Meyerhoff program.

“When we recruit, we don’t talk a lot about Ph.D.s and M.D./Ph.D.s.,” Harmon says. “We talk about legacy,
and we talk about service. We talk about leadership. We talk about being a part of something that’s bigger than yourself.”

Learn more about the Meyerhoff Scholars Program at meyerhoff.umbc.edu.

Photos courtesy of the Meyerhoff Scholars Program.

UMBC’s Glenn Wolfe develops new method to gauge atmosphere’s ability to clear methane, a potent greenhouse gas

New research by UMBC’s Glenn Wolfe and collaborators is shaping how scientists understand the fate of methane, a potent greenhouse gas, in Earth’s atmosphere.

Of the greenhouse gases, methane has the second greatest overall effect on climate after carbon dioxide. And the longer it stays in the atmosphere, the more heat it traps. That’s why it’s essential for climate models to properly represent how long methane lasts before it’s broken down. That happens when a methane molecule reacts with a hydroxyl radical—an oxygen atom bound to a hydrogen atom, represented as OH—in a process called oxidation. Hydroxyl radicals also destroy other hazardous air pollutants.

“OH is really the most central oxidizing agent in the lower atmosphere. It controls the lifetime of nearly every reactive gas,” explains Wolfe, an assistant research professor at UMBC’s Joint Center for Earth Systems Technology. However, “globally, we don’t have a way to directly measure OH.” More than that, it’s well understood that current climate models struggle to accurately simulate OH. With existing methods, scientists can infer OH at a coarse scale, but there is scant information on the where, when, and why of variations in OH.

New research published in Proceedings of the National Academy of Sciences and led by Wolfe puts scientists on the path to changing that. Wolfe and colleagues have developed a unique way to infer how global OH concentrations vary over time and in different regions. Better understanding of OH levels can help scientists understand how much of the ups and downs in global methane levels are due to changing emissions, such as from oil and natural gas production or wetlands, versus being caused by changing levels of OH.

A flying laboratory

NASA satellites have been measuring atmospheric formaldehyde concentrations for over 15 years. Wolfe’s new research relies on that data, plus new observations collected during NASA’s recent Atmospheric Tomography (ATom) mission. ATom has flown four around-the-world circuits, sampling air with the aid of a NASA research aircraft.

This “flying laboratory,” as Wolfe describes it, collected data on atmospheric formaldehyde and OH levels that illustrates a remarkably simple relationship between the two gases. This did not surprise the scientists, because formaldehyde is a major byproduct of methane oxidation, but this study provides the first concrete observation of the correlation between formaldehyde and OH. The findings also showed that the formaldehyde concentrations the plane measured are consistent with those measured by the satellites. That will allow Wolfe’s team and others to use existing satellite data to infer OH levels throughout most of the atmosphere.

inside a research aircraft

“So the airborne measurements give you a ground truth that that relationship exists,” Wolfe says, “and the satellite measurements let you extend that relationship around the whole globe.”

Wolfe, however, is the first to acknowledge that the work to improve global models is far from done. The airplane measured OH and formaldehyde levels over the open ocean, where the air chemistry is relatively simple. It would be more complicated over a forest, and even more so over a city.

While the relationship the researchers determined provides a solid baseline, as most of Earth’s air does, indeed, float above oceans, more work is needed to see how OH levels differ in more complex environments. Potentially, different data from existing NASA satellites, such as those tracking emissions from urban areas or wildfires, could help.

Wolfe hopes to keep refining this work, which he says is at “the nexus of the chemistry and climate research communities. And they’re very interested in getting OH right.”

Getting it right

The current study did consider seasonal variations in OH, by analyzing measurements taken in February and August. “The seasonality is one aspect of this study that’s important,” Wolfe says, “because the latitude where OH is at its maximum moves around.” Considering seasonal shifts in OH concentrations, or even multi-year shifts caused by phenomena like El Niño and La Niña, could be one angle to explore when trying to improve global climate models.

Looking further at OH levels on a global scale using satellite data validated by airplane data could also help scientists refine their models. “You can use the spatial variability and the seasonality to understand at the process level what’s driving OH, and then ask if the model gets that right or not,” Wolfe says. “The idea is to be able to poke at all these features, where we haven’t really had any data to do that with before.”

This new research is one step in the journey to enhancing our understanding of the global climate, even as it is rapidly changing. More accurately understanding how, for example, cutting methane emissions would affect the climate, and how quickly, could even influence policy decisions.

“It’s not perfect. It needs work,” Wolfe says. “But the potential is there.”

Image: The NASA research aircraft used for the ATom mission. Photo by Susan McFadden for NASA.

From dream to drive to degree: Five UMBC journeys

Earning a degree isn’t just a milestone, it’s a special kind of growth experience full of challenges and doubts, inspiration and opportunity. Depending on their path, some students face particular challenges. They may be the first in their family to attend college, or need to work full-time or more to make ends meet while pursuing their degree. Some students are raising a family while working and taking classes.
At UMBC, students from all backgrounds are finding strength in community. They are building networks of support with peers and mentors to reach toward goals together, whether that goal is making a difference in Baltimore City, pursuing graduate school, or setting a powerful example for younger generations.

“You really have no idea what you’re capable of, until you do it.”

Vanessa Gonzalez ’19, American studies, has been completely independent since age 17 and is the first member of her family to graduate from college.
Gonzalez has worked several jobs at once since she left home, and has struggled with health challenges. And still, she’s earned an associate’s degree from Anne Arundel Community College (AACC) and is now poised to graduate from UMBC as a Sherman STEM Teacher Scholar with a 4.0 GPA. She has big dreams that she’s on the path to achieving: to teach math in Baltimore City and one day travel with the Peace Corps. And she’s happy.

Vanessa Gonzalez ’19, American studies, works on a project with Lakeland Elementary School students. Photo by Marlayna Demond ’11 for UMBC.

Gonzalez worked at the YMCA of Central Maryland while she was at AACC. That experience “helped me find my passion for child care and educating children,” Gonzalez says. Since then, she’s continued to grow in confidence and in her commitment to her work.
“Every now and then there are hiccups, but I went from never believing that I would make it past 18 years old to being 24 and accomplishing so much…And I’m pursuing exactly what I love,” she says. “I’m excited every day. It’s just nice having happiness.”
How did Gonzalez accomplish this? “Embrace the hard times,” she says. “Accept the tears. Because you’re going to think: I’m dropping out. I give up. I quit. But the important thing is to not get to that point.”
She tells other students facing challenges: “You’ve gotta push through when you really don’t want to, so you can be where you want to be in the future. You really have no idea what you’re capable of, until you do it, and then you have this overwhelming sense of accomplishment.”
In addition to focusing on a powerful inner drive, Gonzalez notes the importance of being able to access support. Josh Michael, assistant director of the Sherman Scholars, has been one of her greatest champions. Michael juggles a busy schedule, including working one-on-one with several students in the scholars program, “but then he’s still coming in to observe me teach, and giving me feedback, and working with me through my struggles,” Gonzalez shares.

Young woman leads children in a lesson
Vanessa Gonzalez ’19 works on a project with Lakeland Elementary School students. Photo by Marlayna Demond ’11 for UMBC.

When she suffered a concussion and couldn’t use a computer for weeks, faculty members printed class materials for her and worked with her to create a long-term make-up schedule.
Another faculty member “has been exactly where I am,” shares Gonzalez. “Everything she says and she’s done for me is just to make me better and help me achieve my goals.” Seeing her mentor’s success has been encouraging for Gonzalez, especially in the most challenging moments.
Now that she’s made it this far, with the support of the Sherman Scholars staff and her American studies mentors, Gonzalez wants to give back to the community. In Baltimore, she says, “I see homelessness. I see hungry people. I see a lot of struggle. And it hurts.”
“My goal is to be a part of the change that I’d like to see,” says Gonzalez, voicing the goal of so many UMBC students graduating alongside her. “I want to be part of helping lift up a community that deserves more.”

“[My] parents came here to give me a better life, and I’m living it.”

Ashley Batista ’19, biological sciences, is the first member of her family to graduate from college. Her parents emigrated from the Dominican Republic in search of new opportunities, and Batista was determined to make the most of her college experience. She chose to attend UMBC after hearing a woman of color speak at a UMBC event about the opportunities she was able to access as a UMBC alumna.
“I felt like she represented me,” Batista says. “I just felt really empowered, and I enjoyed how rigorous the coursework would be here. I thought it would challenge me but also prepare me well for whatever I choose to do after.”

Ashley Batista ’19, biological sciences, presents her first research poster at SURF 2018. Fernando Vonhoff (left) is her research mentor. Photo courtesy Ashley Batista.

Once on campus, Batista was particularly excited to hear about the Louis Stokes Alliance for Minority Participation summer research fellowship—a program that supports students in historically underrepresented groups in STEM. But because she didn’t have a faculty mentor or research project lined up, she put the application aside. That was until Peter DeCrescenzo, project coordinator in the Office of Academic Opportunity Programs, reached out to encourage her to apply, offering to help connect her with a mentor.
That summer, Batista started working on Alzheimer’s research with biology professor Fernando Vonhoff, and it’s changed her life.
Being in the lab “opened a lot of doors for me to network and to figure out opportunities and programs I could be involved in after graduation,” she shares. She notes that the research itself “was really gratifying. It changed my whole perspective and my goals.” A reproductive health-focused Alternative Spring Break also helped Batista identify her path forward toward an obstetrics or pediatrics career.
On top of her research experience, Batista began organizing multicultural learning events for the UMBC community as a sister in the Zeta Sigma Chi Multicultural Sorority, Inc. That work “helped me understand and teach others about different perspectives, and create an environment where people can be open to discussion, respectful, and nonjudgmental,” she shares. “ I think that’s something that I can transfer wherever I go.”
She adds that her sorority sisters have been a huge source of support during her time at UMBC.
Batista says that while it adds challenges, being a first-generation college student has been motivating. “Whenever I’m feeling overwhelmed, I remember that my parents came here to give me a better life, and I’m living it,” she says. “It motivates me to keep going and make them proud—and to make myself proud, because I know it will be rewarding in the end.”

Ashley Batista ’19 (standing, second from right) and sorority sisters from across the East Coast volunteer at the non-profit Share Baby. Photo courtesy Ashley Batista.

“I’m not alone in the struggles…or alone in my successes.”

Damarius Johnson ’19, Africana studies, is also a first-generation college student as well as a transfer student from the Community College of Baltimore County. Like Batista and her sorority, for Johnson, finding close-knit communities within UMBC has been the key to success. “UMBC has supportive communities that have helped me see college graduation as feasible,” he shares, “and then allowed me to go through the ups and downs that happen as a college student.”
“The McNair Scholars Program has been instrumental as far as focusing my attention on what I’d be pursuing after graduation,” says Johnson. That attention has paid off—he’ll begin a Ph.D. in history at the Ohio State University this fall.
The Transfer Engagement and Achievement Mentoring (TEAM) Program has connected Johnson with mentors and peers who have had experiences he can relate to, such as being the first in their family to attend college, transitioning from community college to a four-year school like UMBC, or experiencing college as a young black man, he says.
Johnson shares, “Having that support has been really helpful in knowing that I’m not alone in the struggles that I have, or alone in my successes. These are people I celebrate with, too.”
Several mentors have helped Johnson through his UMBC journey, and determining his next steps, including Michael Hunt, assistant director of the McNair Scholars Program; Gloria Chuku, professor and chair of the Africana studies department; and James Hamilton, an academic advisor in the College of Arts, Humanities, and Social Sciences. He started at UMBC not knowing what he might do afterward. But now, Johnson says, “I’m most excited about my transition from being an undergraduate to being a scholar in history. I’m excited for what that journey will be like, and to be learning in a new environment.”
“Hopefully it’s the beginning of something good for my family,” says Johnson, who has younger siblings. “I’m really happy to be able to honor them by getting to this point, because they’ve done a lot to support me.”

At UMBC “you can get to where you want to go.”

Like Johnson, Blake Hipsley ‘19, a dual degree recipient in physics and mathematics, was a McNair Scholar. Since his sophomore year, Hipsley has pursued research through the program with Michael Hayden, professor of physics. “Research helped me open up to what I want to do in the future,” Hipsley says. “I had the chance to see if it was something I wanted to do, and I decided it is.” This fall, he’ll begin a Ph.D. in physics at the University of Michigan.
Hipsley’s parents didn’t graduate from college, but always encouraged him to pursue higher education. “My mom always encouraged us to do our best and work hard,” he shares. “I think that’s why I have this drive to always be doing so much, and I put it on myself to pay for my own school.” By applying for a multitude of scholarships and working as a tutor, Hipsley was able fund his UMBC education on his own.
Without family members who had attended college, “The only people I really could talk to about graduate school were my professors,” he says. “They really helped me a lot with getting funding, writing a personal statement, and preparing for the GRE.”

Blake Hipsley ’19, physics and mathematics, talks about his research at URCAD 2019. Photo by Marlayna Demond ’11 for UMBC.

Hipsley also served as the McNair Scholars Program’s inaugural teaching fellow, a role where he advises other McNair students and provides feedback to program leadership. “McNair has helped me not only get into graduate school,” he says, “but also help others who may be struggling.”
The McNair Scholars also supported Hipsley’s personal growth. “One of the benefits of the program is that you get to meet people from all different backgrounds,” he says. As a result, he tried his first sushi and watched his first Bollywood film.
With such a caring community of support, Hipsley says, at UMBC, “If you work hard and keep at it, no matter where you’re from you can get to where you want to go.”

“They’re going to see you finish what you started.”

Nicole Katsikides, Ph.D. ’19, public policy, began her doctoral journey 12 years ago while working full-time for the Maryland Department of Transportation on highway freight transport efficiency. During her Ph.D. studies, she’s had two children, now 6 and 8, and her husband was deployed with the Air Force to the Middle East several times. Two years ago, based on the skills she’s gained through her graduate studies, she was also recruited for a demanding new job with the Texas A&M Transportation Institute (TTI), which she’ll continue after officially earning her doctorate this month.
“There were many times along the journey that I truly didn’t think it would happen,” Katsikides reflects. “I think the way I got through was with very gracious support from my advisor and my committee.” John Rennie Short, public policy; Tim Brennan, public policy; and Scott Farrow, economics, “wanted to see me succeed,” she shares, “and that really helped.”

Nicole Katsikides, Ph.D. ’19, public policy, says by “continuing to plug away” and with the support of “my boss, my family, and my committee, I’ve been able to make it.” She’s pictured here with her husband and children. Photo courtesy Nicole Katsikides.

For Katsikides, the public policy program’s active effort to be accessible to working professionals made all the difference. “Under Dr. [Susan] Sterrett’s leadership, the program has evolved to be something that’s really helpful for people in public positions like I had to succeed,” she says, “and to bring Ph.D. level knowledge into the public sector working environment.” Katsikides also notes that her TTI supervisor, Bill Eisele, was very supportive, especially as she approached the finish line.
Still, Katsikides struggled to balance motherhood with pursuing her career and her education. “It’s very easy for people to say, ‘Why are you doing that?’ or ‘You should be spending more time with your kids.’ There’s still a lot of cultural norms,” she says. She stayed motivated by remembering how her own parents pursued advanced degrees when she was a child.
“I hope that when my kids think about this as they grow up, that they saw what it takes to achieve something. That it’s an example for them,” she shares. “So block out the noise, and keep going—the kids are gonna be alright. They’re going to see you finish what you started.”
Banner image: Vanessa Gonzalez ’19 works with a student at Lakeland Elementary School. Photo by Marlayna Demond ’11 for UMBC.