All posts by: Sarah Hansen, M.S. '15


International team led by UMBC identifies new bird species in the South Pacific

In the 1930s, famed biologist Ernst Mayr became the first to study Pacific Robins. Based on his observations of the robins and other birds on Australia and its outlying islands, he developed foundational concepts that continue to inform the study of evolution. He took copious notes on the birds’ physical characteristics, behaviors, and habitats. Always, he described the robin populations as a single species, albeit with significant variation from island to island. Ernst Mayr made lasting contributions to evolutionary biology—but like most scientists, he wasn’t right about everything.

Bold new claims

Anna Kearns is a former UMBC postdoctoral fellow now at the Smithsonian Institution’s Conservation Biology Institute. With her UMBC postdoc advisor Kevin Omland and other colleagues, she has conducted new investigations into the relationships among Pacific Robins on various islands using many of the same bird specimens Mayr himself used. The difference is, “He would have mainly been just using his eyes” to compare specimens, Kearns says. She and her colleagues have had the advantage of major advances in technology since Mayr’s time. Kearns has built on Mayr’s work by using techniques like DNA sequencing and spectrophotometry, which quantitatively compares the hue, brightness, and saturation of feathers. She has come to a more nuanced understanding of the relationships between, say, a robin on Fiji and one on the Solomon Islands. As a result of this research, Kearns and colleagues from UMBC, the Australian National Wildlife Collection, Australian Centre for Ancient DNA, and the Smithsonian National Museum of Natural History are making bold new claims about the relationships between these birds. In a 2015 paper in Conservation Genetics, Kearns demonstrated that robins living on Norfolk Island, directly east of mainland Australia, are a distinct species from the rest. A new paper in the Journal of Avian Biology published this month indicates two more unique species—one that inhabits the Solomon and Bougainville Islands, and another that lives on Fiji, Vanuatu, and Samoa.

Preserving biodiversity

The new work demonstrates just how much is still unknown about avian biodiversity. “Even in this well-studied group of birds, that’s been a textbook example since 1942, we did not really know what the units of biodiversity were,” says Omland, professor of biological sciences at UMBC, and senior author on the new paper. Understanding those “units of biodiversity” is critical for conservation. When all the Pacific Robins and mainland Australia’s Scarlet Robin were considered a single species (a single unit of biodiversity), the loss of the birds on one or two islands would be unfortunate, but not necessarily very impactful. If those birds were actually the only remaining members of a unique species, however, the same loss becomes catastrophic. “What Anna’s work is showing is that the bird populations on these islands have very distinctive traits,” Omland adds, “so just knowing what the biodiversity is that we want to conserve is super important.”

Unpredictable patterns

The team’s work indicates that all the Pacific Robins are descended from an ancestral Australian population where males were brightly-colored and females were dull-colored. But as small groups of robins colonized the outlying islands, the population on each island took its own evolutionary path. Today, some island groups still maintain the bright male and dull female pattern, but on other islands both sexes have evolved bright coloration. On other islands, both sexes have evolved dull coloration.    “When you look at the genetics, you find two distinct lineages” leading from the common ancestor to all the island populations that exist today, Kearns says. “So that means these patterns have evolved independently multiple times.” Kearns and Omland think the changes have more to do with random forces than evolutionary adaptation. “If we flipped two coins, this is about what we’d expect,” Omland says.  For example, the pattern an island’s population ended up with could depend on the color of the individuals that happened to get blown onto that island initially. Also, in a very small population, the random way genes are redistributed from generation to generation can have a significant impact—as much of an effect or more than natural selection.

Detective work

Kearns and Omland are both excited to have the opportunity to suggest names for the new species they’ve identified. Kearns suggests “Mayr’s Robin” for the Fiji/Vanuatu/Samoa population, in honor of Ernst Mayr’s pioneering study of these birds. But their contribution to ornithology is more than a name. “Because these birds are all on very small isolated islands, and Pacific birds are often on many, many, many isolated islands, collecting is very difficult. So there haven’t actually been that many comprehensive studies,” Kearns says. Revealing the complexity of the relationships among these robins adds much-needed information to the field. It also raises the prospect that other birds—especially those on islands—might have undergone similar, as-yet-unstudied, evolutionary processes.   The work is a unique blend of past and present. “You really wouldn’t be able to do this study without using these old collections,” Kearns says. At the same time, discovering the new species also wouldn’t have been possible without modern techniques.  “It’s kind of like detective work in a way,” Kearns says. “I feel like there’s just so much more we need to know about it. But we feel like we have made a big step forward.” Banner image: Kevin Omland (rear) goes birdwatching at UMBC’s Library Pond with a group of his students. Photo by Marlayna Demond ’11 for UMBC.

UMBC Alumnae Racing to Develop Coronavirus Vaccine 

Kizzmekia Corbett ’08, M16, biological sciences, says it feels like she’s “living in a constant adrenaline rush.” Maybe that’s because she and her team at the Vaccine Research Center at the National Institute of Allergy and Infectious Diseases have been working around the clock for weeks. They’re racing to develop a vaccine for the coronavirus faster than it can race across the globe.

“To be living in this moment where I have the opportunity to work on something that has imminent global importance…it’s just a surreal moment for me,” Corbett says.

Despite it feeling surreal, the advances Corbett and her team are making are very real, and they’re setting records. “We are making better progress than I could have ever hoped for,” she says. After three months of studies in test tubes and in animals, the vaccine her team developed is about to enter a phase I clinical trial, a crucial hurdle on the way to FDA approval.

“Focus, focus, focus”

Corbett says her experience as a Meyerhoff Scholar at UMBC helped prepare her and another core team member, post-baccalaureate researcher Olubukola Abiona ‘17, M25, biochemistry and molecular biology, for a moment like this. “Discipline is one of the biggest things that Meyerhoff taught us,” Corbett says. “And it matters—a lot—in these instances of being pulled in multiple directions and really trying to understand what the priorities are.”

Corbett, who came to UMBC from North Carolina, and Abiona, who attended Eleanor Roosevelt High School in Prince George’s County, also draw on UMBC President Freeman Hrabowski’s consistent exhortation to “Focus, focus, focus,” Corbett says. “The UMBC connection and the training we received there, for both of us, has been instrumental in how we are operating right now,” she adds.

A couple of years ago, Corbett and Abiona were the only members of their team. It’s since grown, but their relationship remains special. “Essentially we started out being the team alone, and as a result, there is this level of trust and understanding that we have with each other,” Corbett says. “It’s extremely rewarding to watch someone exponentially grow into a scientist in the course of a few years,” Corbett reflects. “I think next to getting data, mentoring young scientists is the most exciting and rewarding part of what I do here.”

As an African American woman in STEM, Corbett says she has also experienced people thinking she’s only there because of diversity initiatives. “That’s been a cloud around my movement in science,” she shares. So, she says, “showing up, particularly in a moment like this, and setting a standard about what people from different backgrounds can contribute” is just as important as mentoring the next generation of scientists. 

“Hopefully we will open people’s eyes to the credibility of people who look like us as real scientists.”

Setting the standard

While that message is always in the back of their minds, right now, Corbett and Abiona are deeply focused on the work at hand. “For me, I’m very interested in looking ahead to the kinds of data we’ll get from human trials,” Corbett says. “Yes, we have tons of data that will support this vaccine being a fruitful one and a protective one, but it’s always just a hypothesis until we get some real human data.”

Read about Corbett and Abiona’s work in the New York Times.

If the phase I trials are successful, that will be a huge step toward an FDA-approved vaccine for the coronavirus—and also set a new benchmark for future disease outbreaks. 

“I’m really excited about fulfilling this proof-of-concept for pandemic preparedness, where we can literally go from receiving the genetic sequence of a virus all the way through to a vaccine clinical trial in less than three months,” Corbett says. “I think that’s somewhat of an unprecedented standard to set, and I’m looking forward to helping to standardize it. I hope that it will get even shorter.”

 

UMBC’s Suzanne Ostrand-Rosenberg recognized for 40-year career advancing cancer immunotherapy

After 41 years at UMBC, Suzanne Ostrand-Rosenberg, professor emerita of biological sciences, retired in August 2018 and moved to Utah to enjoy the mountains with her spouse. But she couldn’t stay away from her research and mentoring for long. “I just can’t quit it,” Rosenberg says. “I realized I really did not want to stop.”

That attitude is emblematic of Rosenberg’s dedication to the field of cancer immunotherapy—using the human immune system to fight cancer. It also reflects her commitment to the next generation of researchers. Now, she has been recognized by the American Association of Immunologists (AAI) as a Distinguished Fellow, a very small, international group of scientists known for their deep and lasting contributions to immunology.

“This honor correctly recognizes Sue as a leader in the field of cancer immunotherapy and her early insight that the immune system could be made to target cancer cells more effectively,” says Philip Farabaugh, professor and chair of biological sciences. “It was exciting for me, over the last 20 years, to watch how her lab homed in on this target.”

Part of the reason for Rosenberg’s unabated enthusiasm is that “right now the whole cancer immunotherapy field is at such an exciting stage,” she says. Rosenberg started on this work in the 1970s, and at that time, “nobody thought that the immune system would have any efficacy against cancer.” But in just the last 10 years, a lot has changed. Major advances have led to immunotherapies being used successfully with real patients.

“My generation of researchers in cancer immunology really set the groundwork to enable the type of advances that we’re seeing now in the clinic,” Rosenberg says. “For the people who’ve been in this field a long time, it’s very rewarding.”

Students at the center

For Rosenberg, the success of her research and the success of her students have always been inextricably linked. “The students are the ones that made the success possible,” she says. 

Lucas Horn, Ph.D. ’17, biological sciences, was one of Rosenberg’s final UMBC graduates and is currently a postdoc at the National Cancer Institute. “The lab environment really was a synergistic blend of ideas from all the students and Sue,” he reflects. “The open flow of ideas was often crucial in solving complicated problems, but also helped the students to develop the confidence to suggest ideas and control the direction of their projects.”

Rosenberg equally valued all members of the lab. “I always felt like an important part of the team,” says Lydia Grmai ’11, M19, biochemistry and molecular biology, who participated in undergraduate research with Rosenberg. Rosenberg’s high expectations of her students “gave us the chance to rise to the occasion,” Grmai adds. “She taught me how to really take ownership of a research project, which was instrumental as I began to envision and plan my career as an independent scientist.”

Grmai gives her experience in Rosenberg’s lab, and especially the frequent opportunity to travel to conferences, credit for her rapid advancement through graduate school at the New York University School of Medicine and to her current role as a postdoc at Johns Hopkins University.

“Science communication and professional networking remain two of the most valuable skills in my research career,” Grmai says, “and getting to hone these skills as an undergrad accelerated my growth that much more once I got to grad school.”

Lydia Grmai

The ideal combination

Rosenberg is grateful for the UMBC environment that emphasizes both research and education. That’s why she made UMBC her home for her 41-year professorial career. Many immunology labs are located in medical schools, research institutes, or hospitals , outside of undergraduate academic settings, but Rosenberg knew that connecting with undergraduate students would be a significant part of her career. 

“It was really a combination of the quality and enthusiasm of the students, and being in an environment where I could both be involved with student activities and do research,” she reflects. “The undergrads drive the intellectual atmosphere of the lab as much as the grads and the postdocs do. I’ve been incredibly fortunate to have had undergraduates in my lab who have just been dynamite people.”

Despite her long-term commitment to her field, and significant contributions to immunotherapy research, Rosenberg remains humble. “I was shocked by the company I’m keeping as a Distinguished Fellow,” she says. “I think UMBC is in very good company. It feels good to be right up there with some of the other major players.”

Rosenberg held the Robert and Jane Meyerhoff Chair for Biological Sciences at UMBC for many years, which provided significant financial support that allowed her to send students to conferences and otherwise enhance the lab’s impact. That experience, and the generally supportive environment at UMBC, are top of mind for Rosenberg. “I never would have gotten this award if it hadn’t been for UMBC,” she says. “That’s absolutely true—providing the resources, the support, the students…I’m very grateful to UMBC.” 

Driven by her endless curiosity and inspired by her time at UMBC, Rosenberg is involved in research, writing grants, and graduate education at the University of Utah School of Medicine. With the next big breakthrough in cancer immunotherapy right around the corner, she says, “I just can’t bring myself to quit.”

Banner image: Sue Rosenberg opens the super-cold sample storage. Photo by Marlayna Demond ’11 for UMBC.

Teaching among trees: Field research project grows UMBC partnership with community colleges

When Caitlin Beckjord stepped onto campus for the first time as a UMBC student in fall 2019, she felt energized and prepared to succeed, thanks to a unique, new summer program on urban forestry.

Earlier in the summer, six Howard Community College (HCC) students, including Beckjord, participated in the Baltimore Forest Patches Summer Research Collaboration. This unique pilot project between UMBC and HCC is designed to expand research opportunities for community college students, provide important data on urban forests, and ease students’ transition to UMBC. It also serves to build and strengthen the kinds of relationships that were forged between UMBC and HCC faculty during the STEM Transfer Student Success Initiative (t-STEM).

During the provost-funded pilot, HCC students enrolled in research courses instructed by HCC faculty Will Gretes and Cheryl Campo. Then they participated in fieldwork under the mentorship of UMBC faculty and graduate students. Once they learned about research design and forest ecology in the classroom, they headed outdoors to work in patches of green space across Baltimore City. During their fieldwork, they participated in a practicum course through UMBC’s Shriver Center to help them reflect on their experience.

The students are encouraged to return to this forest project for multiple summers, developing more expertise and taking more responsibility each time. Those who transfer to UMBC come in already engaged in a research project and connected to members of the campus community. 

“It’s a great example of the relationships we’re building with the community colleges,” says Sarah Jewett, director of transfer innovations in research and practice. “What I love about this program is that it utilizes curricular infrastructure that’s in place at the community colleges, and networks and research expertise here at UMBC. We’re really drawing on the assets at both institutions to make this work.” In particular, Howard Community College’s Dean of Science, Engineering, and Technology Patti Turner was an instrumental partner who made the pilot possible and continues to collaborate with UMBC on a variety of projects. 

At home in the forest

The experience opened students’ eyes to the life of an urban forest. After learning about what species they might find, the students took inventory of the plants present and their abundance in forest patches across Baltimore City. Carol Frimpong, who is studying life science and computer science at HCC, became particularly interested in fungi and bacteria along the way.

“This introduced me to environmental microbiology,” she says. “I didn’t realize there was a subfield of microbiology that focuses on the environment. So I hope to go into more of that.” 

For Laura Wortman, the experience has changed her relationship with nature. “I feel like I know more about the forest,” she shares, “and I feel more at home there now that I know different trees and groundcovers.”

Matthew Baker, professor of geography and environmental systems (GES) at UMBC, mentored the students in the program. “Hearing these stories is the best part of my job,” he says. “Most professors get involved in the work that they do because they want to see others be inspired the way they were. It’s really rewarding to listen to students who have found something they enjoyed in this experience.”

Connections across campuses

The program created opportunities for faculty, graduate student mentors, and participating students to build meaningful relationships with one another. For Beatriz Shobe, who is in the GES Ph.D. program at UMBC, the program confirmed her interest in teaching and fieldwork. “I found that teaching in an interactive, hands-on way is a good skill to have that can be beneficial for both traditional classroom teaching as well as community outreach and engagement,” Shobe says.

Shobe’s teaching resonated with Wortman. “Just hearing Beatriz talk about her research was really interesting, because I’d never talked to someone in a casual context before about their research,” Wortman says. “She told us what had gone wrong with her research, and how that changed the entire trajectory of the project.” She explains, “I learned all this stuff that you wouldn’t hear from someone just presenting on their paper, and that was really enlightening.”

As a result of participating in the program, Wortman is now interested in transferring to UMBC to pursue a combined bachelor’s/master’s degree in GES.

Caitlin Beckjord ‘22, geography and environmental systems, already knew she was passionate about research when she joined the program, and it helped her make connections at UMBC. “Meeting with Dr. Baker and Dr. Jewett allowed me to ask questions about UMBC’s classes and opportunities, and get more in-depth campus tours where I was introduced to several other UMBC professors, students, and advisors,” she shares. 

This fall, Beckjord transferred to UMBC, and the experience continues to offer benefits. “Learning how to identify trees and ground cover and work with soils has put me at an advantage in my forest ecology class at UMBC,” she says. Beckjord also has a built-in community on campus; she connects with students and faculty she met during the program on a daily basis.

Commitment to conservation

In addition impacting the students and educators involved, this program also contributes to scientists’ understanding of urban forests, through the data the students collect. 

Baker has been working for the last seven years “to study urban forest patches and understand their composition, their structure, how they’re managed, and how these factors will affect their future,” he says. “We work to provide information to the public through Baltimore Green Space so that they can inform forest stewards and local community members,” such as private landowners whose property includes forest patches. “At the same time, we’ve been asking questions about urban forest patches in general, and developing techniques for studying them and mapping them in concert with the USDA Forest Service.”

This work is important because urban green space and cohabitation of humans with wildlife are critical to modern environmental conservation. Sometimes the research manifests as big findings about the makeup of urban woods and how to preserve or restore them. At other times, the results are more personal. 

As they were gathering important scientific data and learning about research methods, the students in this program also enjoyed the chance to connect with nature in their daily lives. Growing evidence suggests this kind of experience is critical for our physical and mental health, and for growing the next generation’s commitment to conservation.

“I often go on walks, and there is this one beautiful tree I always sit under, but I never knew what it was before this summer,” Frimpong shares. “But then I looked at it recently and I realized it was a red maple.” She’s also learned the names of local birds and, with her new interest in fungi, mushrooms. Growing thoughtful, she shares, “It’s good to know them by name.”

Banner image: A scene from Patapsco Valley State Park in Baltimore County. Photo by Matthew Beziat, used under CC BY-NC 2.0.

All other photos are courtesy of Caitlin Beckjord.

UMBC researchers find many countries will not meet ambitious forest restoration goals without support

The U.N. and other international organizations agree that forest restoration is a critical part of the collective global effort to combat climate change, reduce extinctions, and improve the lives of people in rural communities. Dozens of nations have pledged to restore 230 million hectares of forest so far as part of projects such as the Bonn Challenge and REDD+. The Bonn Challenge goal is to restore 350 million hectares by 2030.

The leaders behind this work agree that ambitious goals are important if humanity is going to avoid the worst effects of climate change. However, a new paper in Conservation Letters has generated the first comprehensive data set that describes how countries are doing so far—and it’s not looking good. The paper looked at 62 countries that have made restoration commitments, and reports that 54 percent of the Bonn Challenge’s goal area for 2020 has not yet been pledged. It then digs into the data to understand why some countries are doing better than others, and what could help those that are struggling.

Maggie Holland in the Amazon region of Ecuador, where she have conducted forest conservation research for the past decade. Photo courtesy Maggie Holland.

Aiming high

The authors found that most of the gap between goals and reality exists in the global South, a group of nations generally south of the equator previously referred to as developing countries. These are also the countries that pledged to restore the greatest amounts of land, the paper reports. For example, Rwanda pledged to restore 81 percent of its total land area, and Burundi pledged 79 percent. One-third of the countries pledged greater than 10 percent of their total area, which would require significant shifts in land use and food production.

The authors hypothesize multiple reasons for the large pledges from global South countries. “It could be that global South countries are more aware of the risks they face from climate change, and are therefore more interested in doing something about it,” says Matthew Fagan, assistant professor of geography and environmental systems at UMBC and lead author on the paper. “They also generally have lower labor and land costs, making it easier for them to do restoration.” On the other hand, they could be trying to access more dollars from international donor organizations to reach these aspirational goals, or could have underestimated the challenges of restoration at that scale.

Maggie Holland in the Amazon region of Ecuador, where she has conducted forest conservation research for the past decade. Photo courtesy Maggie Holland.

The paper also attempted to predict which countries would have the greatest difficulty meeting their goals based on a dozen factors the team analyzed, such as population growth, government corruption, and previous deforestation rates.

Justin Drew ’20, computer science, and a co-author on the paper, compiled the data for all 12 factors by writing computer code to pull quantitative information from public international databases. He also scoured the internet for information on individual countries’ progress. Drew collected reliable information on the 12 factors for all 62 countries making restoration commitments, and progress information for 12 of them. “When we asked how they did based on these twelve factors, we found they did about as well as we expected,” says Fagan. Countries with the lowest combined score considering all the implementation factors tended to be farther from meeting their goals.

Local engagement

But all is not lost. “We’ve identified countries that need help” to achieve their ambitious environmental goals, says Fagan. “It’s clear that there’s a whole set of countries that are facing headwinds, and if we expect them to be able to accomplish their goals, then the international community needs to support them.”

Increased financial aid is important, but so are other means of support. That might mean providing technical tools and training to help governments and local communities make informed decisions about restoration efforts. Above all, it means listening to local communities’ needs and working in collaboration to create solutions.

“Restoration efforts have a better chance of achieving sustained improvement when local communities have a voice early in the process, feel empowered to participate actively throughout, and can experience direct and long-term benefits from these efforts,” says Maggie Holland. She is an associate professor of geography and environmental systems at UMBC and a co-author on the paper.

Maggie Holland (center, rear) interviews a group of farmers in the Amazon about the forests on their properties. Photo courtesy Maggie Holland.

In one location, the best solution might be planting trees on agricultural land, such as shade-grown coffee. Other places, it might be tree plantations, reclaiming agricultural land for forest, or thinning existing forests to prevent fires.

“Different efforts will yield different benefits for mitigating climate change, for helping people, for restoring ecosystem health and conserving biodiversity,” Holland says. She suggests that more social science research on the results of different strategies is needed to deploy them most effectively.

There are other, less direct, efforts that can also have a huge effect on forests. “Even if countries haven’t necessarily made big strides in restoration, in some cases they’re making big policy changes that will hopefully result in restoration in the longer term,” Fagan says. For example, bringing electricity to more rural communities reduces the need for fuel wood and charcoal. That reduces forest loss while also improving human health by removing smoke from homes.

Investing in the foundation

Ultimately, the researchers argue that while it may sound good to pledge huge areas of land, that might not be the best strategy to reach the goals of combating climate change, improving people’s lives, and protecting species from extinction. If countries feel pressured to meet their ambitious goals, they might employ the easiest restoration strategies, such as thinning forest. The U.S., for example, has already met its goal of 15 million hectares, and the vast majority of it was through this method. That may have some beneficial effects, like decreasing the chance of forest fires, but it’s not the same as planting trees on agricultural land or shifting land use patterns.

Maggie Holland runs a focus group with farmers in Ecuador. Photo courtesy Maggie Holland.

In addition to supporting countries in need, “I think the wealthier countries need to get on this bandwagon and do more themselves as well,” Fagan says. Ambitious, but realistic, and locally appropriate goals are the best way to succeed, Fagan and Holland agree.

Overall, Fagan is “guardedly optimistic.” “There’s a lot of potential and a lot of interesting policy work going on. I believe, though, that there’s a time to build your castles in the air, and now it’s time to put foundations under them. We’re underinvesting in the foundations, and we need to spend more international aid money on helping countries figure out how to meet these commitments,” he says.

“I’d like to hope that this article helps generate more support for that kind of work,” Fagan shares, “because I think it is possible to make this kind of change.”

Banner image: Maggie Holland (far left) and Lee Blaney (second from right), associate professor of chemical, biochemical, and environmental engineering, about to plant trees at a coffee plantation in Costa Rica with a group of UMBC students. Photo courtesy Maggie Holland.

UMBC’s Pelton and Daniel are developing light-driven chips to enable super-fast computing

By combining their expertise in physics and chemistry, Matt Pelton and Marie-Christine Daniel are working toward the next big leap in computing. Both are engaged in photonics research, which is “the idea of using light—photons—to do information processing instead of using electrons like you do in electronics,” explains Pelton, associate professor of physics at UMBC.

Using light rather than electrons, as in fiber-optic telecommunication cables, is “faster, and you can send a lot more information,” Pelton says. However, no computer today runs exclusively on photons. “The huge pipeline of data coming down optical fibers all has to be converted to an electrical signal and then distributed to all the different processors in the computer. That’s the big power and time bottleneck,” Pelton says.

“If you could do as much of the function of the computer chip as possible using photons instead of electrons, then you would be able to use less power and do things more efficiently,” he says. “So there’s a big push to try to bring photonics down to the single chip scale.”

That’s where this interdisciplinary duo comes in. They’re working to develop a unique combination of existing chemical structures to enable photon-driven computer functionality even in the computer’s most fundamental building blocks. A new three-year grant from the National Science Foundation will enable Pelton and Daniel to make faster progress on their project and involve more students.

A new kind of switch

Daniel and Pelton’s novel technique depends on being able to reliably create very specific chemical structures. By binding two types of known structures in a particular arrangement, they can create a kind of on-off switch. 

At its most basic level, a computer is just a lot of these switches. Whether they use ones and zeros, light and dark, or something else, the pattern of the switches encodes information. The new kind of switch that Daniel and Pelton are devising is different from what computers use now, because it relies on photons rather than electrons.

The light-driven structures Daniel and Pelton are working to build are made of quantum dots and metal nanoparticles. Quantum dots are tiny crystals only about 20 atoms in diameter. They’re made of semiconductor elements, similar to the silicon that powers electronics, and they can be designed to emit certain wavelengths (colors) of light. They’re even used in some televisions. The metal nanoparticles are larger, usually a few thousand atoms in diameter. They also appear as different colors based on the light they reflect and absorb, but they don’t emit their own light.

Through computer simulations, Pelton and Ph.D. student Vijin Veetil have demonstrated that by binding two rod-shaped nanoparticles (“nanorods”) and a quantum dot together in a specific way, their interaction can produce a structure that allows light to pass straight through both the dot and particle, when it would normally be scattered. Transmitting the light creates a transparent state rather than an opaque one. That switch from transparent to opaque, which can be controlled by an external beam of light, is exactly the kind of switch that could encode information in a computer.

Getting it just right

For this to work, Pelton and Daniel need to successfully construct molecular structures consisting of a single quantum dot stuck between two nanorods.

“It needs to be that configuration,” says Daniel, associate professor of chemistry and biochemistry, who is bringing on chemistry Ph.D. student Chanda Lowrance to help her tackle this project. “The quantum dot alone, or the nanoparticles alone, will not induce the transparency effect.” 

And just any quantum dot bound to any nanoparticle is not sufficient. They need to have specific sizes and shapes, so that the wavelength of light that the quantum dot absorbs, and the wavelength that the nanoparticle scatters, are very similar, Daniel explains. Then, “they can interact very efficiently and create that transparency.”

“That’s essentially the goal of this project—to take these structures from a cartoon to something we can actually make,” Daniel says. “And making this is not easy.” If Daniel, Pelton, and their students can do it, though, they’ll be setting the stage for a revolution in computing.

From random to reliable

Previous research has shown that it’s fairly straightforward to get the nanoparticles and dots to clump together in groups. “But we need to get just one of them. And we don’t want it to bind just anywhere. It has to be right there,” Pelton says. “That’s the big challenge.”

A procedure that allows metal particles and dots to bind together randomly does result in a very small number of structures in the desired configuration. When scientists tested those lucky few for the transparency effect, they matched results predicted by Pelton’s simulations, proving this technique can work.

Now, the challenge is producing a larger number of these structures. “When we’re synthesizing these things, we don’t want just a few of them to be the right structure; we want the majority of them to be the right structure,” Pelton says. “We need the ability to make them in much larger numbers, in order to be able to optimize them.” 

This is what the team is working on now. Their goal is that “by the end of the project we’ll have shown that we can make these things reliably, in larger numbers, and that we can use them as an on-off switch,” Pelton says.

The power of teamwork

“I didn’t know if this was going to work when we started,” Pelton says. But considering their progress so far, and the impact this new funding will have on accelerating their work, today Daniel and Pelton are optimistic about the future of light-based computing and other applications for their joint research.

While the work poses significant challenges, “of course it’s a big opportunity, too,” Pelton says. In addition to the duo’s goal to create light-driven computer chips, there could be other scenarios where it would be beneficial to combine nanoparticles. Different configurations could generate new and useful physical and chemical properties for all kinds of applications. 

Daniel and Pelton recognize the importance of their collaboration for the success of this work. Pelton’s theoretical and simulation expertise as well as his ability to do single-particle measurements, and Daniel’s in-depth knowledge of the chemistry and ability to find a way to make specific structures, have all been critical. 

“This is not something that any physicist or chemist could do alone,” Daniel reflects. “It takes both.”

Banner image: Matt Pelton (right) and Haixu Leng, Ph.D. ’19, physics. Photo by Marlayna Demond ’11 for UMBC.

Preparing for impact: Four new UMBC grads share what drives their research

It’s 3 a.m., and Cindy Chelius rolls out of the pull-out couch in the grad student lounge. Time to check on her fungi. For this experiment, measurements must be taken every four hours for forty hours. Thankfully, the undergraduates she mentors took the day shift. Tonight, as the lead on the project, it’s her turn.
“I think it just makes you feel like you really earned it when those results come back,” Chelius says. She has earned it—on December 18, she’ll walk across the stage to receive her Ph.D. in chemical and biochemical engineering from UMBC. The signaling pathways of fungi might seem like niche research, but fungal species are commonly used in industry as tiny, living factories. They can produce substances found in an array of products, including medications.

Cindy Chelius, Ph.D. ’19 (third from left) with her advisor Mark Marten (far left) and the rest of their lab group. Photo courtesy Cindy Chelius.

After graduation, Chelius will take her skills to Bristol-Myers Squibb’s upstream processing development team in Devens, Massachusetts. She’ll help the company improve the ways they use organisms to produce therapeutic compounds. 
Chelius’s UMBC experience has prepared her well for a research career in ways that go beyond a successful dissertation. Encouraged by her Ph.D. advisor, Mark Marten, professor and chair of chemical, biochemical, and environmental engineering, Chelius learned how to use bioreactors. “These industry positions really like someone coming in with that working knowledge,” she explains.

Chelius also took advantage of the Biochemical Regulatory Certification program at UMBC, organized by Tony Moreira, vice provost for academic affairs. It’s a four-course series including training in FDA regulations and good manufacturing practices, local lab tours, and more. “I think it really helped with my job interviews, because I was able to understand the acronyms they were talking about and reference the literature on these topics,” Chelius says.
She’s also expanded her cultural awareness by being active in a dynamic, diverse department with students and faculty from across the U.S. and the world. By participating in department intramural basketball and soccer teams and other departmental social events, “I definitely learned a lot more about different cultures and opinions,” Chelius shares. “Everyone comes from different places here, and it’s been awesome.”

Cindy Chelius, Ph.D. ’19, fourth from left, with her intramural soccer team. The team includes members of the labs of Mark Marten and Lee Blaney (third from right). Photo courtesy Cindy Chelius.

Freedom to explore

Miranda Marvel, who is graduating with her Ph.D. in marine and estuarine environmental sciences, studied zebrafish development at the Institute of Marine and Environmental Technology with Yonathan Zohar, professor and chair of marine biotechnology. Her research focused on the role of a fish hormone, revealing that it plays important roles in feeding and reproduction. Understanding both processes is critical to optimize the aquaculture industry. After she defended her thesis in August, Marvel assumed a new post as a postdoctoral fellow at the National Institutes of Health, where she continues to study zebrafish development.
“Yoni encourages independent thinking and gave me the freedom to come up with my own experiments and be the leader on their execution,” Marvel says. “Ten-Tsao Wong was also always willing to drop whatever he was doing to help me.” Wong was a postdoctoral fellow when Marvel joined the lab, but later transitioned to assistant professor of marine biotechnology at UMBC. 

Miranda Marvel, Ph.D. '19, center in front row, with the IMET REEF program participants. Photo courtesy Miranda Marvel.
Miranda Marvel, Ph.D. ’19, center in front row, with the IMET REEF program participants. Photo courtesy Miranda Marvel.

Like Chelius, Marvel also took advantage of opportunities to receive training beyond her research. She participated in the Ratcliffe Environmental Entrepreneurship Fellowship (REEF), which offers training in business skills. “The skills you learn—like networking, public speaking, and making an elevator pitch—can be applied anywhere,” Marvel says.
As a result of the program, Marvel developed SensorFish, a line of fish bred to change color when they first experience common stressors, and took third place in UMBC’s 2018 Cangialosi Business Innovation Competition. The color change allows people to take action quickly to keep their fish healthy, even before symptoms may be apparent.

Miranda Marvel, Ph.D. '19, gives her pitch at the 2018 Cangialosi Business Innovation Competition. Photo courtesy Miranda Marvel.
Miranda Marvel, Ph.D. ’19, gives her pitch at the 2018 Cangialosi Business Innovation Competition. Photo courtesy Miranda Marvel.

When she arrived at UMBC, Marvel says she was quiet and shy. But the REEF training and supportive university environment changed that. “Seeing how helpful and friendly everyone was during my time here really helped me come out of my shell,” she says. “I attribute that to the collaborative nature of UMBC and IMET, and especially the researchers’ willingness to support young scientists.”

Creating positive change

Naqiya Ghulamali ‘19, psychology, has also been transformed by her research and service-learning experiences, which she sees as going hand in hand. Her research with Bronwyn Hunter, assistant professor of psychology at UMBC, focused on factors that influence the experience of re-entering society after incarceration. In an internship at the International Rescue Committee, Ghulamali says, “I got to work directly with clients on their paths to self-sufficiency during resettlement.”
As a result of these experiences, Ghulamali shares, “I am pursuing careers where I can apply my skills and knowledge to create positive social change.”

Naqiya Ghulamali '19, psychology, during her internship at the International Rescue Committee. Photo courtesy Naqiya Ghulamali.
Naqiya Ghulamali ’19, psychology, during her internship at the International Rescue Committee. Photo courtesy Naqiya Ghulamali.

UMBC mentors like Hunter and Ghulamali’s academic advisor Nkiru Nnawulezi, assistant professor of psychology, have influenced her future path. “They supported me and encouraged me to pursue my goals,” Ghulamali says. “Dr. Hunter and the graduate students in the lab helped me with projects and conference presentations, and generally created an environment conducive to critical thinking.”
Leaders of UMBC’s Alternative Spring Break and the STRiVE program, a five-day leadership retreat organized by the UMBC Center for Democracy and Civic Life, also shaped Ghulamali’s UMBC experience, and her future. “I’m grateful for how they’ve contributed to my sense of my own civic agency,” she shares.
As a member of the Honors College and a Sondheim Public Affairs Scholar, Ghulamali not only met mentors and established her career path, but also forged friendships “with others deeply invested in public service,” she says.

The power of an open door

Ryan Oliver ’19, biological sciences, also met life-changing mentors at UMBC. After struggling with addiction for almost four years at a college in another state, he took a year off to begin recovery with family in Maryland. When he was ready to return to college, Oliver chose UMBC because of what he had heard about the rigorous academics and supportive atmosphere.
It was a good choice for Oliver. This December, he will graduate with a 4.0 GPA. Next fall, he’s headed to his first-choice graduate school, Hebrew University in Israel.
Oliver’s master’s degree will focus on neuroscience using bees as a model organism. This builds on research he completed with UMBC’s Fernando Vonhoff, assistant professor of biological sciences, for which he received an Undergraduate Research Award. That project explored environmental factors that affect how fruit flies respond to alcohol exposure, and whether or not they become addicted.

Ryan Oliver '19, rear, green shirt, with members of Fernando Vonhoff's lab. The lab members include undergraduates, graduate students, and a high school student. The UMBC students affiliate with programs such as STEM BUILD, LSAMP, MARC U*STAR, and the Meyerhoff Scholars. Photo courtesy Fernando Vonhoff.
Ryan Oliver ’19, rear, green shirt, with members of Fernando Vonhoff’s lab. The lab members include undergraduates, graduate students, and a high school student. The UMBC students affiliate with programs such as STEM BUILD, LSAMP, MARC U*STAR, and the Meyerhoff Scholars. Photo courtesy Fernando Vonhoff.

The connection between his personal experience and academic research is no accident. “I would say my history has opened the door into neuroscience for me,” Oliver shares.
When he came to UMBC, Oliver knew he wanted to pursue undergraduate research, so he started knocking on doors. The first open office door he came to belonged to Vonhoff, who welcomed him in for an impromptu meeting. “By the end of that first conversation, he told me I could develop any project I wanted, and he would support me,” Oliver recalls. “I think him letting me do that is what really sparked so much enthusiasm and dedication on my part.” 
During his time at UMBC, Oliver traveled to University of Chicago to present his research at the Society for Neuroscience Annual Meeting. Oliver is drafting the manuscript for a scientific paper on which he will be the first author.

Ryan Oliver presents his research at UMBC's Undergraduate Research and Creative Achievement Day 2019. Photo courtesy of Fernando Vonhoff.
Ryan Oliver presents his research at UMBC’s Undergraduate Research and Creative Achievement Day 2019. Photo courtesy of Fernando Vonhoff.

Regarding his identity as a person in recovery, “I’ve been able to create more opportunities by being open about it than if I had hidden it. And I don’t think most people realize that,” Oliver says. “I think it needs to be destigmatized, and hopefully I’m doing my part in that by being as open as I can so that other people can get help, be embraced, and be given a chance in the real world.”
“My message would be that UMBC is a place that encourages and enables success through connection with and discovery of a real, personal identity,” he shares.
As they move beyond UMBC, Chelius, Marvel, Ghulamali, and Oliver all remain driven to contribute to positive change in their communities through their research. They also hope to carry forward the support they found at UMBC as mentors to a future generation of researchers.

Banner image: Ryan Oliver, second from left in back, with Fernando Vonhoff, third from right in back, and members of the lab in summer 2019. Oliver served as a mentor to members of the UMBC STEM BUILD program. Photo courtesy Fernando Vonhoff.

UMBC’s Lisa Kelly receives NSF grant to develop a safer, greener chemical production method

At some point in its development, every drug, high-tech piece of clothing, and synthetic building material was touched by a chemist. However, getting the atoms attached to each other in just the right way to treat infection, keep you dry in the woods, or construct your home often requires extreme measures. Harsh chemicals and dangerous byproducts from those manufacturing processes have the potential to cause environmental damage and impact the health of lab workers.

Lisa Kelly, associate professor of chemistry and biochemistry at UMBC, is developing techniques to make some of those same chemicals in much safer ways. The National Science Foundation has funded her with $450,000 for three years to further this work, which also has biomedical applications.

“The approach that we propose will induce chemical reactions that would otherwise need a lot of harsh reagents and organic solvents, and just a lot of nasty stuff,” Kelly says. “This is a greener route.”

Radical reactions

The technique Kelly is using can be very helpful for inducing the formation of strong chemical bonds between two molecules, when their interaction would typically be much weaker. 

The first step is to chemically attach a special compound to one of the two molecules you want to connect. Shining UV light on the compound causes it to release a single atom with a negative electric charge, called a radical. Because it is charged, that atom will react strongly with molecules around it. In this case, the radical initiates the formation of a strong bond between the two molecules you want to connect. The only byproduct of the reaction is carbon dioxide, and it can be carried out in water, so it’s much safer than existing methods.

This process can be used for a variety of purposes. For example, you can induce strong bonds between a drug and its target to better understand the drug’s mechanism. This essentially freezes their fleeting interaction in time, giving a scientist the chance to observe it. 

“It’s a photochemical tool to be able to visualize where the drug actually bound,” Kelly says. “That lets you say, ‘This drug is so powerful because it binds here and this one is less powerful because it binds here.’” That kind of insight could lead to more effective pharmaceuticals.

This technique can also be used in a more general biological context, to better understand how an enzyme and its target protein interact. And it could increase the efficiency and safety of generating polymers—long chains of molecules—used in various industries, like adhesives or flame retardants. It could also be used to add molecules to surfaces to give them desirable properties.

Adding to the biological toolbox

With the NSF funding, Kelly’s lab will look at how efficiently different compounds can create radicals, and what kinds of reactions the radicals are best at initiating. She’s hoping that their findings will be useful for researchers in a range of fields, including medicine. “They could take the information that we’ve disseminated and then use it in their bigger biological toolbox,” Kelly says.

Kelly is also involved with a startup in Utah using a similar technique to create a natural alternative to the metal stents that treat heart disease. Staining the artery with the special compounds and then exposing them to light creates a rigid structure that avoids the need for a traditional stent. The product is currently undergoing FDA approval.

“We’re able to give guidance to the drug discovery companies based on our insight into the chemical mechanisms,” Kelly says. “That’s what’s really exciting to me: We can actually come up with practical information to help guide better drugs and structural biology tools.”

Creating opportunities for students

Kelly is also excited about how her new funding will impact UMBC students. “Part of the grant support is not just doing the lab work, but also disseminating it, so my team and I can travel to present the work at national conferences,” she says. “It’s really important to me to be able to bring graduate students with me when I go to meetings and have them share the same sort of networking opportunities that I benefited from.”

Kelly has cultivated rich connections within the photochemistry community, a field she chose intentionally. “It struck me as a way to be able to do everything that I was interested in without having to be this or this or that,” she says. “It was a multidisciplinary, practical field that’s served me well in my career.” And now, she’s introducing UMBC graduate students to this unique field and how scientists can bridge multiple disciplines to impact society.

As a photochemist, “It’s not good enough for me to make something and show that it does something cool,” Kelly says. “I want to map out all the driving forces that control it, and when I understand that, then I can make the process happen better.” 

Banner image: Lisa Kelly, right, Ryan Grant, center, and Gabriella Pozza work with the laser setup in Kelly’s lab. All photos by Marlayna Demond ’11 for UMBC. 

Team led by UMBC’s Mehdi Benna is the first to map a planet’s global wind patterns, and they weren’t Earth’s

Today, a paper published in Science documents for the first time the global wind circulation patterns in the upper atmosphere of a planet, 120 to 300 kilometers above the surface. The findings are based on local observations, rather than indirect measurements, unlike many prior measurements taken on Earth’s upper atmosphere. But it didn’t happen on Earth: it happened on Mars. On top of that, all the data came from an instrument and a spacecraft that weren’t originally designed to collect wind measurements. 

In 2016, Mehdi Benna and his colleagues proposed to the Mars Atmosphere and Volatile EvolutioN (MAVEN) project team that they remotely reprogram the MAVEN spacecraft and its Natural Gas and Ion Mass Spectrometer (NGIMS) instrument to do a unique experiment. They wanted to see if parts of the instrument that were normally stationary could “swing back and forth like a windshield wiper fast enough,” to enable the tool to gather a new kind of data. 

Initially, the MAVEN project team was reluctant to implement the modifications Benna and his colleagues requested. After all, MAVEN and NGIMS had been orbiting Mars since 2013, and they were working quite well collecting information about the composition of the Mars atmosphere. Why put all that at risk? Benna and his colleagues argued that this project would collect new kinds of data that could shape our understanding of the upper atmosphere on Mars, inform similar studies on Earth, and help us better understand planetary climate. 

Benna, a planetary scientist operating out of the NASA Goddard Space Flight Center with the UMBC Center for Space Sciences Technology (CSST), came up with the windshield-wiper idea while brainstorming how to create an instrument that could collect information about global circulation patterns in Earth’s upper atmosphere. It occurred to him that, together, MAVEN and NGIMS could do the same thing on Mars—and they were already in space.

With some persistence and a lot of preliminary analyses, Benna and his colleagues convinced the MAVEN mission leadership to give their idea a try, after Lockheed Martin, the spacecraft manufacturer,  determined the modifications might be possible without damaging the satellite. “It’s a clever reengineering in flight of how to operate the spacecraft and the instrument,” Benna says. “And by doing both—the spacecraft doing something it was not designed to and the instrument doing something it was not designed to do—we made the wind measurements possible.”

Ripple effect

The new paper was completed in collaboration with Yuni Lee, also of UMBC’s CSST, and colleagues from the University of Michigan, George Mason University, and NASA. It is based on data collected two days per month for two years from 2016 to 2018. Some results were expected, and others were big surprises. “The refreshing thing is that the patterns that we observed in the upper atmosphere match globally what one would predict from models,” says Benna. “The physics works.”

Overall, the average circulation patterns from season to season were very stable on Mars. This is like saying that on the East Coast of the United States, throughout the year, weather systems generally flow from the West to the East in a predictable way. 

One surprise came when the team analyzed the shorter-term variability of winds in the upper atmosphere, which was greater than anticipated. “On Mars, the average circulation is steady, but if you take a snapshot at any given time, the winds are highly variable,” Benna says. More work is needed to determine why these contrasting patterns exist.

A second surprise was that the wind hundreds of kilometers above the planet’s surface still contained information about landforms below, like mountains, canyons, and basins. As the air mass flows over those features, “it creates waves—ripple effects—that flow up to the upper atmosphere” and can be detected by MAVEN and NGIMS, Benna explains. “On Earth, we see the same kind of waves, but not at such high altitudes. That was the big surprise, that these can go up to 280 kilometers high.”

Benna and colleagues have two hypotheses for why the waves, called “orthographic waves,” last so long unchanged. For one, the atmosphere on Mars is much thinner than it is on Earth, so the waves can travel farther unimpeded, like ripples traveling farther in water than in molasses. Also, the average difference between geographic peaks and valleys is much greater on Mars than it is on Earth. It’s not uncommon for mountains to be 20 kilometers tall on Mars, whereas Mt. Everest is not quite nine kilometers tall, and most terrestrial mountains are much shorter. 

“The topography of Mars is driving this in a more pronounced way than it is on Earth,” Benna says.

Forging ahead

Continuing to analyze the data from this study may help scientists figure out whether the same basic processes are in action on Earth’s upper atmosphere. Ironically, “We had to go take these measurements on Mars to eventually understand the same phenomenon on Earth,” Benna says. “Ultimately the results will help us understand the climate of Mars. What is its state and how is it evolving?”

But the team isn’t satisfied with the current data set. “We want to keep measuring. We have two years of data, but we’re not stopping there,” Benna says. Even with the data set they already have, “We have many years of modeling and analysis ahead of us.” It’s a trove of information that can be examined in ways not yet imagined, to learn even more about how planets work.

Banner image: The MAVEN spacecraft orbits Mars (artist’s concept), courtesy of NASA.

Climate Shift

From Eritrea to UMBC, this physicist is cultivating a diverse generation of climate scientists. 

It’s a nearly cloudless afternoon at UMBC in early October. A group of physics students and their two faculty advisors, Belay Demoz and Ruben Delgado, make their way to the roof of the physics building to continue their conversation about atmospheric research. Earlier, gathered in a small, dimmed lecture hall, the students engaged their advisors and each other in robust discussions about their research while practicing their presentation skills.

In that session, Amanze Ejiogu ’22, physics, had the chance to explain his findings on the Bay Breeze. Rather than an adult beverage, it refers to breezes coming in off the Chesapeake Bay that redirect back to land air masses (and the pollutants they contain) that would otherwise blow offshore. 

The Bay Breeze effect is a complicated phenomenon. Many factors contribute to it, from precipitation to wind speed to the overall quality of the air. Understanding it is a multidisciplinary effort, requiring chemistry, fluid dynamics, statistics, and meteorology skills. That’s exactly the kind of challenge that Demoz, physics professor and director of UMBC’s Joint Center for Earth Systems Technology (JCET), likes to help his students tackle.

After Ejiogu’s presentation, Demoz asks questions. His elbow leaning casually against a railing, he breaks into a grin—he is in his element. Of a certain result, he asks, “Is that expected?” And a minute later, “That’s for you to figure out,” his Eritrean accent inflecting his speech.

Demoz engages his students in robust discussions about their research. Photo by Marlayna Demond '11.

Climate change and other environmental issues like air and water quality disproportionately affect people of color. Today, Demoz sees his role at UMBC as empowering students, especially students from underrepresented backgrounds, to take ownership of their research and contribute to their communities. Eventually, he hopes his graduates will also become mentors and advocates for their own students and colleagues—behaviors he models for them every day.

This wasn’t always Demoz’s idea of what his life’s work would be. After a challenging childhood in what is now the East African country of Eritrea, Demoz came to the United States for graduate school in the 1980s. His original goal was to learn how to seed clouds—to bring rain to his drought-stricken homeland. He’s still doing climate research, but his focus has shifted. His experiences as a youth in Eritrea and his years as an African in the United States have shaped who he has become and what he seeks to achieve.

Graduates from all backgrounds have left Demoz’s lab and taken roles at places like NASA, the National Oceanic and Atmospheric Administration (NOAA), the Environmental Protection Agency (EPA), and other research institutions. These alumni create a ripple effect that will continue to enhance diversity in atmospheric research and answer questions that have the potential to change the lives of people around the globe, in part because of Belay Demoz.

Maurice Roots, a graduate student in atmospheric physics, has already felt the effects of Demoz’s efforts. Roots, who graduated from Hampton University, only applied to UMBC for graduate school because Demoz approached him at a conference. “Belay has a great set of stories to tell,” Roots says. “His journey shows that perseverance is possible.”   

A changing homeland

“It’s where the desert and the green are always fighting.”

That’s how Demoz describes the location of Eritrea. It’s a small African country on the Red Sea, sandwiched between Sudan and Ethiopia, right where the Sahara Desert and the jungles of central Africa meet. Many people there are subsistence farmers, including generations of the physicist’s family.

It used to be that when drought or floods hit, Eritrean farmers moved to where the grass was literally greener. But that changed after their land was colonized by the Italians and later the British. Strict political borders limited movement. “Once you put a wall, that valve of mitigating drought disappears,” Demoz says.

His childhood and youth in Eritrea, in the 1960s and ’70s, was one of the most volatile times for the region, when an internal resistance movement was fighting Ethiopia to gain independence. “My time was a time of coups, a time of drought, a time of war,” Demoz says. “Those are the times when a lot of heartache happened.”

Many people died because they weren’t allowed to migrate. Their crops failed in the drought, and some starved. Some died when they attempted to migrate and met violence along the way. Demoz’s older brother and many of his friends perished fighting in the resistance.

An unlikely advocate

Belay Demoz knew the challenges his people were facing. So in 1980, when he finished high school and was assigned to study physics as an undergraduate at the University of Asmara in what was to become Eritrea, he knew he wanted to find a way to use his education to make things better for his family.

At first, he struggled. He failed his first three exams. And then the first of several major turning points in his life happened, the first time help came from where he least expected it. 

Demoz and his roommate frequently played soccer together. Both were highly talented but knew there was no career for them in the sport. So, after Demoz failed his third physics exam, his roommate decided it was time for an intervention.

“You can play soccer so well, but you’re going to let physics twist you?” he asked Demoz. “No, you study with me.” So he did. And by the next semester, Demoz was at the top of his class. “Part of me was afraid,” Demoz admits. Why? His roommate had recently been released from prison on a murder conviction. But “if I didn’t find him, I don’t think I would have made it.”

As his undergraduate career was coming to a close in 1984, another severe drought hit Eritrea. Demoz wanted to do something, but he didn’t know how his nuclear physics degree could help the situation. Then, he learned about cloud seeding in a Physics Today article.

In the 1980s, cloud seeding seemed like the next big revolution in weather modification. In order for clouds to produce rain, the water molecules they contain need to condense into liquid form. That happens around tiny solid particles inside the cloud. Cloud seeding adds these particles, creating more opportunities for raindrops to form.

“That’s when I switched from nuclear to atmospheric physics,” Demoz says. “I wanted to help make it rain.”

He applied and was accepted to the atmospheric physics program at the University of Nevada, Reno, but to leave Eritrea, he had to promise that he would come back. Without the required funds to guarantee that promise, his parents had to put their family home on the line so that he could study in the U.S.

“I was given $50 and a plane ticket,” Demoz remembers. “My dad didn’t blink. He just said, ‘Go. We will find a way.’”

Peaks and valleys

In Nevada, everything was new and different. “At 22, it was my first time to see snow,” Demoz says. And not just through his dorm room window—his courses and research involved spending ample time in the Sierra Nevada Mountains. After replacing his dress shoes with snow boots and skis, Demoz began to learn his way around the mountains.

In addition to the new climate, there were other steep learning curves for Demoz in graduate school. One of the core courses required computer programming skills. One day, Professor Jim Telford—Demoz refers to him as a “cloud giant”—called Demoz into his office.

Telford devised the stochastic rain theory when he was a master’s student in the 1960s, which describes why and predicts when clouds will produce rain. Today there is still no better theory. Demoz describes him as an arrogant, brilliant Australian scientist, who also went to great lengths to ensure his students’ success. Demoz remembers their first conversation going something like this:

“You must be pretty good in programming,” Telford says.

“No, I’m not.” Demoz replies.

“Well, have you used a computer?” Telford asks. 

“No.” 

“Have you touched a computer?” 

“No.” 

As Demoz recalls, Telford roared with laughter and rushed to another room to share with a colleague the ridiculousness of a Ph.D. student in physics who had never touched a computer.

“At this point, I’m thinking, I’m doomed!” Demoz remembers. “But there’s something inside me saying, I am an Eritrean, and others are fighting for independence. There’s something instilled in me. And so I stood there.” And instead of throwing him out, Telford agreed to give Demoz a crash course in computing.

Demoz in grad school, after mastering the necessary computing skills. Photo courtesy of Demoz.

For two weeks, Demoz sat with a clunky 1985 desktop and a pile of Fortran books in Telford’s office, learning how to program. Today, Demoz tells his students, “If you cannot compute, you cannot compete. Everyone who has achieved something in our field is good in programming.” But his experience with Telford was about more than programming. It was about a mentor making a special effort to help a student succeed. Belay carries that memory with him today and strives to pay it forward to his own students.

In addition to learning all about clouds and weather modification, and completing a dissertation titled, “Sierra Nevada Winter Storms Using Microwave Radiometry, Ice Crystal, and Isotopic Techniques,” Demoz learned something else important in Reno—what it felt like to be black in the United States, especially in higher education and especially in physics. 

In front of the Desert Research Institute circa 1991 with a fellow graduate student. Photo courtesy of Demoz.

He noticed it right away in his courses (he was the only black person) and in the city. “It takes a toll,” he says. “Reno had a very tough police force.” He was stopped on many occasions as he drove home late from doing research in the mountains, seemingly for nothing. “I tend to be an outlier,” he reflects. “You don’t see a lot of black people doing cloud seeding and working with snow.”

Only later would he find out that the graduate program had accepted him as a “test case”—he was the first African accepted to the program and the first to graduate with a Ph.D. He remembers John Hallett (another “cloud giant” and another of Demoz’s important mentors) telling him, years later, “We wanted to see if those schools [in East Africa] were any good. That’s why we admitted you.” That, of course, didn’t sit well with Demoz and stayed with him as his future in physics unfolded.

Shifting the landscape

Once he finished his Ph.D., Demoz pursued postdoctoral studies at the University of Illinois in cloud chemistry. In 1997, UMBC finally entered his experience. He completed a second postdoc with UMBC at the NASA Goddard Space Flight Center in Greenbelt, Maryland.

Demoz continued his work at NASA after his postdoc ended. Then, another life-changing moment: He got a call from Howard University to help create a new atmospheric research center there in 2006. “The whole reason I studied this field was to go back and seed clouds,” Demoz reflects. “That wasn’t happening, but I realized, there is plenty to be done here.” So Demoz jumped at the chance to contribute to the historically black university while continuing his research program at NASA. 

“It was around that time that I started to be conscious of my status as a minority in the field,” Demoz remembers. “It bothered me, being one of the only ones.”

At a conference around then, Demoz and a handful of other atmospheric researchers of color met in the lobby. “And we asked, OK, what is our part?” Their first step was to join efforts in developing the Howard research center together. 

In 2005, Demoz was awarded a NASA Administrators Fellowship—a two-year sabbatical during which recipients are expected to build up a program at a minority-serving institution. The fellowship allowed Demoz to focus full time on building up the research center in Beltsville, which is administered by NOAA. When the two years were up, Demoz didn’t go back to his research program at NASA, choosing instead to commit himself permanently to the work of increasing the success of minorities in atmospheric science.

“Most people thought I was crazy because NASA is a stable job for life,” Demoz says. “But thinking about all the support that I had growing up, I decided my place was there.”

Building the pipeline 

Over the next several years, Demoz and colleagues built up the NOAA Center for Atmospheric Science (NCAS) at Howard University’s campus in Beltsville, Maryland. The NCAS is a “super-site” among the Global Climate Observing System (GCOS) Reference Upper Air Network (GRUAN), a set of sites worldwide that looks at air and cloud chemistry.  People around the world rely on the data it collects and the analyses the Beltsville researchers (including many students) conduct for their own work. The Beltsville GRUAN site contributes powerfully to science and also to increasing the diversity of scientists. It is the only GRUAN site in the world operated by a university, which is a source of pride for Demoz.

Students who’ve studied at the GRUAN site from Howard, UMBC, and elsewhere—many of them from underrepresented backgrounds—have gone on to careers at preeminent government and private research organizations. “You can involve students no matter how specialized and difficult your science is,” Demoz says. “The Beltsville site has made quite a number of important scientific advances and also brought diversity to the federal agencies.”

At the same time, the small group of African and African-American climate researchers who had met at the conference in the early 1990s started to formalize their lobby conversations into an official event at other meetings. “It paid off. We used to meet in a bar in the hotel lobby at the American Meteorological Society conferences. Right now, Colour of Weather is perhaps the biggest minority-focused group in atmospheric sciences, and it is what we started,” Demoz says with pride. “It’s held in a ballroom. I look at that and I think, I didn’t go back to Eritrea and seed clouds, but I’m making a difference here.”

Bringing a meaningful vision to life 

With his experience at NASA and as a professor of physics at Howard, and his commitment to mentoring students from all backgrounds, Demoz was a perfect fit to serve as the next director of UMBC’s JCET, a partnership with NASA formed in 1995, when the position opened up in 2014. 

As JCET director, Demoz has clear ideas about what he wants to accomplish. “If I can get a really strong, diverse graduate program here, that would be great. And I think that’s possible here.” In addition to recruiting and mentoring students from diverse backgrounds, Demoz says continuing to diversify the faculty is also a worthy goal. The UMBC physics department is already off to a strong start, with faculty members from Brazil, Eritrea, China, Hungary, Greece, and Puerto Rico.

Students are noticing the changes Demoz has modeled. “He really cares about his students and wants them to succeed,” adds Kylie Hoffman, a third-year graduate student. “He wants to help you do what you want to do.” 

Demoz with a group of his students on top of the physics building. Photo by Marlayna Demond 11.

He supports graduate and undergraduate students alike. After giving his presentation at the lab meeting, sophomore Amanze Ejiogu expected that “a seasoned atmospheric science veteran would pull it apart like cotton candy,” he says. But Demoz didn’t. “He was very respectful and asked genuine, thoughtful questions that will help me take my research forward.”

“Belay has been a great mentor for teaching lessons that are never covered in a classroom,” says Brian Carroll, a fifth-year Ph.D. candidate. “I’m proud to be part of such a diverse research group,” Carroll adds. “Thanks to my experiences with the group, I will pursue and highlight diversity in my own workplaces and the community at large as I progress in my own career.”

When asked about Demoz’s mentoring, Maurice Roots is more straightforward: “He’s good at it,” Roots replied. “So I’m taking notes.”

Demoz himself benefited from support and mentoring—sometimes from unlikely places. “Help will come from the place you least expect it, so be open,” Demoz says, maybe remembering the time a convicted murderer got him through his nuclear physics degree or an arrogant scientist made sure he was ready for programming class. Or maybe even the time he got the green light from Howard University to start the Beltsville Climate program or the call from UMBC to apply for the JCET directorship. 

It’s all part of Demoz’s story. Now he’s taken it as his mission to help students create their own stories, with a strong start at UMBC. 

“By seeing us,” he says, “I hope that students say, ‘I belong here.’”

*****

Header image: Demoz meets with students on top of the physics building. Photo by Marlayna Demond ’11. 

UMBC’s Aaron Smith examines molecular role of iron in human health with $1.5M in new grants

UMBC’s Aaron Smith is now thinking “bigger picture” about how his lab’s research can support human health at the molecular level thanks to $1.5 million in new research funding. 

Smith, assistant professor of chemistry and biochemistry, focuses on how biological systems take up and process iron. Last winter he received a significant grant for research on developing new antibiotic targets. Now, he’s earned a prestigious $500,000 National Science Foundation CAREER Award and $1 million from the National Institute of General Medical Sciences, a division of the NIH. The work he and his students are doing is at the molecular level, but it has implications for everything from cardiovascular disease to embryonic development.

Opening the molecular toolbox

Smith’s bioinorganic chemistry lab works to understand how metals function in biological systems, with a particular focus on iron. While it may be strange to think about metals functioning in our bodies, they are critical. “For biological systems to expand the types of chemistry that they can do, they need metal ions,” Smith says. “Metals open up the toolbox for the protein to be able to accomplish so much more.” 

The NSF and NIH funding will allow Smith’s lab to increase understanding of how iron is involved in adding molecules to proteins after they are made. This process is known as post-translational modification. 

Post-translational modifications are incredibly important,” Smith says. Even the most complex organisms don’t have more than a few tens of thousands of genes that provide instructions for unique proteins, but proteins perform many times that many functions in the body. Post-translational modification “really diversifies the number of functions that proteins can serve,” Smith says. 

Smith’s lab is studying a specific post-translational modification called arginylation. An enzyme known as ATE1 carries out arginylation, by attaching the amino acid arginine to proteins. Then, “the arginine functions as a molecular flag that says, ‘I should be degraded,’” Smith explains. The ability to break down the right proteins, and then use their building blocks to rebuild other cellular materials, is crucial for the healthy functioning of our bodies over time.

“ATE1 is very impactful, but we don’t know a lot about how it does what it does,” Smith says. Even the structure of ATE1 is unknown, as well as the mechanism by which it adds arginine to proteins. Smith says his lab has an idea, “but my guess is it’s going to be much more complex when we figure this out.”

Smith’s research niche: the atomic level

Research on arginylation is increasing rapidly, and Smith believes his lab has a particular role to play. Most labs are looking at arginylation at the cellular level and up, asking questions like how it affects different processes in a cell or even an entire organism. But Smith is taking things to another level by studying the atomic structure of individual ATE1 enzymes and the proteins they interact with. 

“We think that we fit in very nicely in this research space,” Smith says, “We’re filling a niche that remains really uncovered at this point.”

Smith’s group is looking at how ATE1 is regulated, such as how it knows which proteins to add arginine to or how it responds to changes in the cell. They’ve already gotten some promising results related to iron’s role in regulating ATE1. And they’re getting close to revealing the enzyme’s complete molecular structure, which would provide big clues into how it works. The NIH and NSF funding will help answer these questions.

Once the structure and mechanism are in hand, it will be time to explore applications. For example, “Could we think about then making this protein a target for therapeutic development?” Smith asks. “Given how important it is in these various cellular processes, if we understood better the structure and the mechanism, we could think about ways to develop small molecules that could help with diseases associated with arginylation.”

Representation in research

In addition to aiding the progress of his research, Smith is excited that both grants will allow him to expose more students to bioinorganic chemistry. His CAREER Award proposal “has an additional education component that’s about specifically trying to leverage the diversity efforts already going on here at UMBC, and to help increase diversity in bioinorganic chemistry.”

To that end, Smith will introduce all of the first-year chemistry courses at UMBC to bioinorganic chemistry. He’s also developing a new upper-level elective on bioinorganic chemistry. Smith hopes that by taking the course, students may then “consider going into a research career for a field that they didn’t even know existed, that helps tackle some of the most important chemical transformations on the planet.”

“I’m proud to think that my lab reflects the diversity that we see on UMBC’s campus, and I’m happy to continue moving forward with that,” Smith shares. “It’s important to have a lab that reflects this university and the country, to benefit from a broad range of perspectives and to train the researchers of tomorrow.”

This new funding will significantly expand the opportunities available to Smith and his students, and it’s reshaping how they think about the work. Having strong funding “affords you the ability to imagine more,” he says, “to think bigger picture about different avenues you might pursue.” Now, Smith and his students will be dreaming big as they steward this new research funding to better understand arginylation, metal transport, and their roles in human health.

Banner image: Aaron Smith works with his students in the lab. From left to right: graduate students Alexandrea Sestok, Verna Van, and Nathan Max. All photos by Marlayna Demond ’11 for UMBC.

We have liftoff! UMBC-developed mini satellite launched into space to study climate, air quality

In the early morning hours of  Saturday, November 2, a few hundred guests at the NASA Wallops Flight Facility gathered at the VIP launch viewing site—a grassy pad near a large tent. Sitting on metal bleachers and in camping chairs, they gazed upward. The NASA Antares rocket and Northrop Grumman’s Cygnus capsule stared back at them from two miles away, more than 14 stories high and loaded with supplies for the International Space Station (ISS). Also on board were more than 30 “cubesats”—small satellites no bigger than large loaves of bread—all of them containing scientific instruments their makers hoped would contribute to a better understanding of our world.

One cubesat, the Hyper-Angular Rainbow Polarimeter (HARP), has been a labor of love for a small group of dedicated UMBC scientists and engineers for the last five years. There were times when they weren’t sure if HARP would ever get to space, but the big moment had finally arrived. Today, HARP was headed up. Way up.

Around 9:55 a.m., the crowd quieted. Their thoughtful silence spoke to years of late nights, early mornings, sighs and tears, hugs and high-fives. They thought back to team meetings with frantic napkin scribbling, spacecraft models made of children’s toys when an idea struck at home, and big dreams.

UMBC’s Roberto Borda, one of the core engineers for HARP, stood at the front of the viewing area, his arms around his wife. “It’s happening, it’s happening!” he whispered excitedly in her ear. Other team members stood nearby with their spouses, children, and friends.

The crowd collectively held its breath and squinted across open fields at the rocket, which was backed almost directly by the low morning sun. And then, finally, it got loud. Really loud. The silent guests watched as Antares and Cygnus roared to life, 440,000 pounds of oxygen fueling eight massive explosions generating upwards of a million pounds of thrust.

At exactly 9:59:37, right on schedule, the rocket burst from its restraints and bolted upward into the sky. Cheers erupted, and the nervous tension dissipated as the rocket rose ever higher. Within four minutes, it was 100 miles above the Earth, headed to the space station at 17,000 miles per hour.

A few minutes later, champagne bottles popped and the celebration began.

Observing particles in Earth’s atmosphere

The HARP satellite’s unique sensors will collect new kinds of information about clouds and tiny particles in Earth’s atmosphere, such as wildfire smoke, desert dust, and human-generated pollutants. These particles, collectively known as aerosols, have a multitude of effects on the global climate and the health of organisms. For example, rain droplets condense around the particles, so they play a role in global precipitation. The particles can also reflect light away from Earth as well as trap energy inside Earth’s atmosphere, which both affect climate. And pollutants can lead to various respiratory ailments in humans and other animals.

With its innovative design, HARP is able to observe the particles from many angles at once to give scientists a more comprehensive view of what’s going on in the atmosphere. The new data will equip scientists with information they need to better understand climate and air quality concerns. 

“HARP is really a technology demonstration mission,” explains Vanderlei Martins, the lead researcher on HARP and director of UMBC’s Earth and Space Institute, “but our goal is to also do some science with the data.”

The team is comprised of engineers, physicists, and mathematicians. “As an engineer, I’m looking to develop technology that can make the science happen,” says Dominik Cieslak, an assistant research scientist with the Joint Center for Earth Systems Technology (JCET), a UMBC partnership with NASA. Other team members are developing algorithms to effectively analyze the data that will eventually be arriving in huge quantities. Cieslak notes that the data could be used in new ways for years to come as researchers develop new algorithms and computing power continues to grow.

Awaiting “first light”

“We’re going to celebrate every step,” Martins said on the morning of the rocket launch. He is careful to note that the launch is just one step—a particularly exciting one—in a still-lengthy sequence. Only when the satellite is orbiting Earth and sending back data will he and his team know if HARP is working the way they intended.

Cieslak shared Martins’ cautious optimism. “There are many ways for things to go wrong,” he said, “but there is only one way for everything to go right.”

To increase the likelihood of things going right, the team tested HARP many times on two different kinds of aircraft that fly at high and low altitudes, to ensure the instrument is working properly. But still, says Borda, “It’s a different beast going in a plane versus going to space.”

On Monday, November 4, the Cygnus capsule made it safely to the ISS. Another step completed. In about a month, astronauts will launch it and its cubesat companions into space. If that goes smoothly, the satellite will stabilize and enter low-Earth orbit. Then, Earth-bound instrumentation will need to successfully establish a connection with the satellite for transferring data. 

If that succeeds, the team will anxiously await the first images from the satellite, which Martins refers to as “first light.” “I’ll really really celebrate when we get the first light,” Martins says.

An important day

Despite the additional steps to come, the launch “is a big milestone,” says Brent McBride ’14, physics, a current Ph.D. student in atmospheric physics. With the setbacks the project has experienced over five years, to arrive at launch day “is a wonderful thing.”

“We’re all really invested in the spacecraft and the work that will come out of it,” says Ryan Martineau, from the Utah State University Space Dynamics Laboratory, which partnered with UMBC on HARP, and “there’s still more to do.”

Karl Steiner, UMBC’s vice president for research, was thrilled to witness his first NASA rocket launch, especially after being inspired by the moon landing and Apollo missions as a child. “To have seen Vanderlei and his team work on this as long as I’ve known them, and know the amount of work and sacrifice they’ve put in, the chance to be with them on this important day…” He trailed off, brimming with emotion. “It’s a very special day for the team and for UMBC.”

At a pizza party after the launch, the team members reminisced about the time they’ve spent together—some as many as 15 years on other projects and five years on HARP—as the excitement of making it to this next big step began to sink in.

“Life can surprise you. Even five years ago I couldn’t have imagined I’d be here today. So keep dreaming,” said Cieslak. “Keep dreaming.” 

Banner image: Vanderlei Martins, Roberto Borda, and Dominik Cieslak with HARP at UMBC. Photo by Marlayna Demond ’11 for UMBC.