Samuel Barnett ’25, biochemistry, is on his way to the Ph.D. program in cellular and molecular biology at the University of Pennsylvania this fall, after seizing opportunities to conduct research at Howard Community College and then at UMBC. Always mindful of how others have supported him and wanting to pay it forward, Barnett has served in leadership roles in UMBC student organizations and created resources to help his classmates land their own opportunities.
Q: How did you choose your major?
A: My high school biology teacher at Wilde Lake was adamant about getting high school students involved in STEM. Even though the course was online because of the pandemic, she was still able to enrapture people in the wonders of biological sciences. I added the chemistry aspect because I wanted to dive a little bit deeper into how everything works from a basic science perspective. The interdisciplinary nature of biochemistry can sometimes make things a little more challenging, but also fun. Actually, if what I’m doing isn’t challenging, it’s not going to be as fun, I don’t think.
Q: How did you choose UMBC?
My research mentor at Howard Community College, Joseph Sparenberg, nominated me for the BUILD a BRIDGE to STEM (BBS) Internship at UMBC, part of the STEM BUILD program, after my sophomore year. I can confidently say that BBS was the most crucial turning point of my undergraduate career, making the shift from HCC to the “bigger pond” of UMBC much smoother. The mission of the BBS internship was to give transfer students a sense of belonging while immersing them in biological research. While I had research experience from Howard Community College, BBS made me feel like a researcher at UMBC.
The BBS mentors gave us a lot of autonomy and intellectual freedom to create our own projects, and I acquired experience that was relevant for my lab at UMBC and a later internship at the University of Pennsylvania. I also connected with a diverse network of mentors, familiarized myself with unique scholarship and scientific presentation opportunities, and met fellow community college transfers who helped inspire me to become the scientist I am today.
Q: How did you get connected with your research mentor at UMBC, Fernando Vonhoff, and what are you studying?
A: It’s a funny story, actually—Dr. Vonhoff grew up in Mexico and is fluent in Spanish, and one day he stepped in for my UMBC Spanish teacher. I talked to him after the Spanish class about his work and later visited him in his office to learn more. Even though his lab is mostly focused on behavioral neuroscience, I was up front about the fact that I’m interested in molecular biology. Dr. Vonhoff could have said I wasn’t a good fit, but he gave me a chance and connected me with one of his Ph.D. students, Zach Smith, who does a lot of the molecular work in the lab. Gaining those molecular skills has opened up doors for me when it comes to getting research experience.
I started in the lab in January 2024. Initially, I worked with Zach to master skills like qPCR and later Western blotting—foundational research techniques for identifying and quantifying genetic material and proteins in a sample. This semester I’ve been trusted to do Western blotting completely on my own.
Dr. Vonhoff’s lab works with fruit flies, a common model system for lots of kinds of studies. I’m trying to figure out a better way to identify the presence of a specific very tiny protein in the flies. Because it’s so small, it’s hard to visualize using traditional Western blotting. We tried a procedure that added a larger, fluorescent protein to the small protein to make it easier to see on the blots. It didn’t pan out, but that happens! So now we’re trying to go back to the basics and find new ways to observe the really small protein, but it’s really difficult.
That was definitely disappointing, but I think at the end of the day that’s just how the scientific process works. Progress ebbs and flows. We’re always asking, what can we do beyond this?
Samuel Barnett
That was definitely disappointing, but I think at the end of the day that’s just how the scientific process works. Progress ebbs and flows. We’re always asking, what can we do beyond this? Maybe another type of test or approach will work. I think the best way to approach those challenges is just optimism and to engage your curiosity and expose yourself to alternative solutions.
Q: Along with Vonhoff, who else has supported you along the way?
A: I first met Dr. Maria Cambraia, assistant director for research and international affairs in CNMS, through the BUILD a BRIDGE to STEM internship, and she has since been one of the most influential people on my undergraduate journey. She advised me on what pathways to take when I transferred to UMBC, gave me opportunities to present at national conferences, wrote letters of recommendation for anything and everything under the sun, and has been an overwhelming source of support throughout my undergraduate career. It is genuinely difficult to quantify the impact she has had on me and my fellow undergraduates.
Dr. April Householder, director of undergraduate research and prestigious scholarships, has also been essential in making sure that my place at UMBC was seen and heard. She helped me apply for the prestigious Goldwater and Knight-Hennessy Scholarships, and was always there to lend an ear. She worked overtime with the Goldwater representative at HCC, Cheryl Campo, to help me get my application submitted.
Q: What are you most proud of from your time at UMBC?
A: I am most proud of winning the Barry Goldwater Scholarship. According to the Barry Goldwater Scholarship website it is “the most prestigious undergraduate scholarship in the natural sciences, mathematics, and engineering in America.” An academic institution can select up to five students to apply for the scholarship, including one slot for transfer students. Originally, I competed for the transfer slot at UMBC, but wasn’t selected. However, at a national conference I attended, I met the president of the Goldwater foundation, who told me about a policy change that allowed transfer students to reapply at their previous institution. That led to Dr. Householder and Dr. Campo rushing to help me get my application submitted as a nominee from HCC. In April 2024, I got the email that I had won the scholarship. At the moment I won, I could hardly believe it; I was quite literally shaking and overjoyed.
Q: What else are you involved in at UMBC, and how have those activities benefited, challenged, or surprised you?
A: In addition to research, I’ve served in leadership roles as the vice president of the American Chemical Society’s (ACS) UMBC chapter and secretary of the UMBC chapter of the Tau Sigma National Honor Society, an honor society specifically for transfer students. I’ve also been a tutor for analytical chemistry on campus and volunteered regularly at Grassroots Crisis Intervention.
The biggest surprise was my position within the ACS chapter here. It turned out to be a bigger job than I expected. I compiled a list of 200+ active internships to help out other students. Recently, I leveraged one of my connections at the Institute of Marine and Environmental Technology to invite a guest speaker to campus. A lot of my work for the ACS chapter was self-driven, but I’m grateful to the group’s advisor, Dr. Maria van Staveren, who really supported my ambitions to make the position into more than the minimum required.
Q: What’s next for you, and what are you looking forward to?
A: This fall, I’ll begin a Ph.D. in cellular and molecular biology with a concentration in cancer biology at the University of Pennsylvania. I was an intern at Penn’s Center for Cellular Immunotherapies in summer 2024, and I had a really good time there. The rigorous research environment was just enthralling to me. I was able to focus completely on being a researcher for the first time. I had my own independent project, under guidance from a postdoc. It was really intimidating at first. At Penn, you’re able to work through the entire research process and bring new things to the table.
Q: What has been the best part of your UMBC experience?
A: The best part of my UMBC experience has been the opportunity to meet mentors that have defined my career. I’ve been given a lot of opportunities, and sure, I’ve taken initiative and put in effort, but at every step of my undergraduate journey, I’ve had a mentor in my corner who’s been willing to lend me a hand and give me a chance.
UMBC offers many opportunities for undergraduates to get connected to administrators and research faculty. In my experience, faculty have always been friendly and open to connecting with undergraduates. I am extremely grateful to both UMBC and my mentors for the continued support throughout my career, and all that support has inspired me to try to give back, through efforts like the ACS internship database.
Q: What advice do you have for transfer students and aspiring undergraduate researchers?
A: Don’t feel afraid to reach out to everyone—faculty members, classmates, staff. They can all help you. And if they don’t respond via email, you can go to their office to introduce yourself. Even in a period of uncertainty, move forward anyway—research is still necessary and important. Stay ambitious, and stay involved in science.
Read more Commencement 2025 stories.
Tags: Biochemistry, ChemBiochem, CNMS, undergradresearch
