Research interests
Our research investigates chemical senses using methods of electrophysiology, functional imaging, immunocytochemistry, and behavior assay in transgenic mice. Current research focus is to elucidate effects of acute and long term exposure to environmental chemicals causing irritation on the chemosensory system including olfactory and trigeminal systems and to find out how the systems maintain the sensory functions during the chemical challenges adapting the environmental changes.
Education
- Ph D, Study on Ca2+ current and Ca2+-dependent Cl- current in cultured trigeminal ganglion cells using whole-cell patch recording — Teikyo University School of Medicine (1993)
- , (Medical Science), Department of Physiology — Niigata University School of Medicine (1987)
- MS, Department of Biology, Faculty of Science — Niigata University (1985)
- BS, Department of Biology, Faculty of Science — Niigata University (1983)
Publications
- IntegraPose: A unified framework for simultaneous pose estimation and behavior classification 2025
- Chemosensory tobacco product toxicology part 1: sensory mechanisms. 2025
- Chemosensory tobacco product toxicology part 2: toxicological testing, assays, and state of the science 2025
- Modification of the Peripheral Olfactory System by Electronic Cigarettes. 2021
- Electronic Cigarette Liquid Constituents Induce Nasal and Tracheal Sensory Irritation in Mice in Regionally Dependent Fashion 2020
- TRPM5-expressing Microvillous Cells Regulate Region-specific Cell Proliferation and Apoptosis During Chemical Exposure 2020
- Mice lacking transient receptor potential channel M5-expressing microvillous cells show different changes in the expression of neurotrophins and their receptors in the main olfactory system in response to chemical exposure 2018
- ATP and odor mixture activate TRPM5-expressing microvillous cells and potentially induce acetylcholine release to enhance supporting cell endocytosis in mouse main olfactory epithelium 2018
- Lack of TRPM5-expressing microvillous cells in mouse main olfactory epithelium leads to impaired odor-evoked responses and olfactory-guided behavior in a challenged chemical environment 2017
- Dichotomous Distribution of Putative Cholinergic Interneurons in Mouse Accessory Olfactory Bulb 2017
- Increases in intracellular calcium via activation of potentially multiple phospholipase C isozymes in mouse olfactory neurons 2014
- Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium 2014
- An effective manual deboning method to prepare intact mouse nasal tissue with preserved anatomical organization 2013
- Automated measurement of nerve fiber density using line intensity scan analysis 2012
- Diverse populations of intrinsic cholinergic interneurons in the mouse olfactory bulb 2012
- Cholinergic microvillous cells in the mouse main olfactory epithelium and effect of acetylcholine on olfactory sensory neurons and supporting cells 2011
- Chemoreception regulates chemical access to mouse vomeronasal organ: Role of solitary chemosensory cells 2010
- Vagal gustatory reflex circuits for intraoral food sorting behavior in the goldfish: Cellular organization and neurotransmitters. J Comp Neurol 2009
- TRPM5-expressing solitary chemosensory cells respond to odorous irritants 2008
- Immuno-localization of Vesicular Acetylcholine Transporter in Mouse Taste Cells and Adjacent Nerve Fibers: Indication of Acetylcholine Release 2007
- Acetylcholine and acetylcholine receptors in taste receptor cells. Chemical Senses 2005
- A chromaffin cell model to simulate calcium dynamics and secretory responses in various conditions. In “Cell Biology of the Chromaffin Cell” 2004
- Expression of P2Y1 receptors in rat taste buds. Histochem. Cell Biol 2004
- Modeling of stimulation-secretion coupling in a chromaffin cell. Pluger Arc Eur J Physiol 2004
- Making sense with TRP channels: Store-operated calcium entry and the ion channel Trpm5 in taste receptor cells. Cell Calcium 2003
- Responses to di-sodium guanosine 5’-monophosphate and monosodium L-glutamate in taste receptor cells of rat fungiform papillae 2003
- Acetylcholine increases intracellular Ca2+ in taste cells via activation of muscarinic receptors. J. Neurophysiol 2002
- Acid-activated cation currents in rat vallate taste receptor cells 2002
- Taste receptor cell responses to the bitter stimulus denatonium involve Ca2+ influx via store-operated channels. J. Neurophysiol 2002
- Maintenance of rat taste buds in primary culture. Chemical Senses 2001
- Neural networks distinguish between taste qualities based on receptor cell population responses. Chemical Senses 2001
- IP3-independent release of Ca2+ from intracellular stores: A novel mechanism for transduction for bitter stimuli. J Neurophys 1999
- Bitter taste transduction of denatonium in the mudpuppy, Necturus maculosus. J Neurosci 1997
- Functional nonequality of the cardiac and skeletal ryanodine receptors. Proc Natl Acad Sci USA 1997
- Chloride current observed as calcium-gated tail current in trigeminal ganglion neurons of the marine catfish, Plotosus. Brain Res 1993
- The membrane properties and Ca-currents of the trigeminal root ganglion cells in primary culture of the marine catfish, Plotosus, studied with whole-cell recordings. Brain Res 1992
- Binding Properties of Sea Anemone Toxins to Sodium Channels in the Crayfish Giant Axon. Comp Biochem Physiol 1988
- Effects of histrionicotoxin derivatives on ion channels and acetylcholine receptor-channel complexes in bullfrog sympathetic ganglia. Comp Biochem Physiol 1988
- Potential-dependent action of Anemonia sulcata toxins III and IV on sodium channels in crayfish giant axons. Pflugers Arch -Eur J Physiol 1988
- Respiratory inhibition by cyanide and salicylhydroxamic acid on the three species of Paramecium in stationary growth phase. Comp Biochem Physiol 1985