A wide range of research projects center on this
sub-discipline including synthesis, structural characterization
and structure determination, the study of chemical reactivity,
and the mechanisms of organic transformations and associated reactive
intermediates and transition states, chiefly of biologically/biochemically
active compounds of carbon. Groups here focus extensively on synthesis
of nucleoside and nucleoside-like compounds, protein/enzyme binding
agents and bio-mimetic complexes. There is also systematic study
of reactions and reactive intermediates and the effects of structure
on reactivity and mechanism, predominantly of electrophilic species
such as epoxides, diazonium ions and carbocations. Additional
areas of interest include the structure of, and factors affecting
the distribution of, covalent adducts of nucleosides and polynucleotides.
Synthesis of thiolated dendrons for the use in gold nanoparticles stabilization.
Mechanisms of biologically relevant organic reactions. Particular emphasis is on the chemistry of reactive intermediates of cancer causing agents and cancer chemopreventives.
The energetics of neutrals and related ions; aromaticity and antiaromaticity; strained rings; compounds with novel functionalities and their energetics.
Synthesis of new tetrapyrrolic derivatives and arrays for fluorescence bioimaging.
Development of unique state of the art synthetic organic strategies to solve chemotherapeutic design challenges for the construction of modified heterocycles, carbohydrates and carbocyclic moieties.
Design and synthesis of anti-viral and anti-cancer compounds
Bioorganic chemistry; synthetic carbohydrate chemistry; chemoenzymatic synthesis