Research programs here are directed towards understanding
disease and oxidative damage, structure/reactivity of diverse
compounds and related ions, and developing computational and spectroscopic
tools for structural biology and homeland defense. This generally
cross-disciplinary research relies on a combination of spectroscopic,
biophysical, computational, and theoretical methods to address
fundamental problems in chemical dynamics, energetics, and structure.
Specific examples of ongoing research in inorganic chemistry include
elucidating the role of metals in biology, including diseases
such as Alzheimer’s and those initiated by oxidative damage.
Projects employ a variety of spectroscopies, including absorption,
fluorescence, electron paramagnetic resonance (EPR) and circular
dichroism (CD). Computational and theoretical efforts that focus
on strained, aromatic, and “exotic” compounds cross
the boundaries of physical, organic, and inorganic chemistry.
Laser spectroscopy is applied extensively to understand photochemical
events. For example, ultrafast spectroscopy initiates and probes
the earliest events of photochemical reactions to understand and
even predict the topology of chemical reactions. Time-correlated
single-photon counting can reveal the mechanism of response of
fluorescent polymers, fabricated for environmental sensing applications.
Computational chemists at UMBC are developing novel methods to
predict the structure and vibrational energy transfer processes
in proteins. In addition, ongoing research programs focus on application
of neutron scattering and terahertz spectroscopy for structural
determination of macromolecular assemblies.
The materials that our lab works on are hard inorganic materials that are synthesized through bio-templating.
Dynamics of Charge Separation
Preparation of gold nanoparticles functionalized with different types of dendrons.
Synthesis of gadolinium-functionalized dendrons
Time-resolved spectroscopy is used to elucidate the mechanisms of photoinduced DNA and protein modification. Structure-reactivity correlations in polymer dynamics.
The chemistry of compounds of the nonmetals, especially those containing fluorine, the noble gases and boron; species with exotic structures and their energetics.
Physical chemistry underlying structure, function and dynamics in biological molecules