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Office: MRF/UMB S516
Phone: 410-706-4980
Professional Interests
Research Group
Wuyuan Lu
B.S. Nanjing University, China 1984; Ph.D. Purdue University, West Lafayette 1994; Post-Doctoral The Scripps Research Institute, La Jolla 1996

88. Liu M, Li C, Pazgier M, Li C, Mao Y, Lv Y, Gu B, Wei G, Zhan C, Yuan W, Lu W-Y, Lu W (2010). D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms. Proc Natl Acad Sci USA 107(32):14321-6. (Featured by SciBX


87. Li C, Li X, Lu W (2010). Total chemical synthesis of human T-cell leukemia virus type 1 protease via native chemical ligation. Biopolymers 94(4):487-494.


86. Smith JG, Silvestry M, Lindert S, Lu W, Nemerow GR, Stewart PL (2010). Insight into the mechanisms of adenovirus capsid disassembly from studies of defensin neutralization. PLoS Pathogens 6(6):e1000959


85. Moulaei T, Stuchlik O, Reed M, Yuan W, Pohl J, Lu W, Haugh-Krumpe L, O'Keefe BR, Wlodawer A (2010). Topology of the disulfide bonds in the antiviral lectin scytovirin. Protein Sci 19(9):1649-61.


84. Liu M, Pazgier M, Li C, Yuan W, Li C, Lu W (2010). A left-handed solution to peptide inhibition of the p53-MDM2 interaction. Angew Chem Int Ed Engl 49(21):3649-52.


83. Li S, Bozzo L, Wu Z, Lu W, Romerio F (2010). The HIV-1 matrix protein p17 activates the transcription factors c-Myc and CREB in human B cells. New Microbiol 33(1):13-24.


82. Li C, Pazgier M, Li J, Li C, Liu M, Zou G, Li Z, Chen J, Tarasov SG, Lu W-Y, Lu W (2010). Limitations of peptide retro-inverso isomerization in molecular mimicry. J Biol Chem 285(25):19572-81.


81. Li C, Pazgier M, Li C, Yuan W, Liu M, Wei G, Lu WY, Lu W (2010). Systematic mutational analysis of peptide inhibition of the p53-MDM2/MDMX interactions. J Mol Biol 398(2):200-13.


80. Wei G, Pazgier M, de Leeuw E, Rajabi M, Li J, Zou G, Jung G, Yuan W, Lu WY, Lehrer RI, Lu W (2010). Trp-26 imparts functional versatility to human alpha-defensin HNP1. J Biol Chem 285(21):16275 85. (Selected by Faculty of 1000 Biology as a Recommended Paper


79. de Leeuw E, Li C, Zeng P, Li C, Buin MD, Lu WY, Breukink E, Lu W (2010). Functional interaction of human neutrophil peptide 1 with the cell wall precursor lipid II. FEBS Lett 584(8):1543-8.


78. Zhang Y, Doherty T, Li J, Lu W, Barinka C, Lubkowski J, Hong M (2010). Resonance assignment and three-dimensional structure determination of a human alpha-defensin, HNP-1, by solid-state NMR. J Mol Biol 397(2):408-422.


77. Lafferty MK, Sun L, DeMasi L, Lu W, Garzino-Demo A (2010). CCR6 ligands inhibit HIV by inducing APOBEC3G. Blood 115(8):1564-71.


76. Li C, Pazgier M, Liu M, Lu WY, Lu W (2009). Apamin as a template for structure-based rational design of potent peptide activators of p53. Angew Chem Int Ed Engl 48(46):8712-5.

(Featured by SciBX


75. Wei G, de Leeuw E, Pazgier M, Yuan W, Zou G, Wang J, Ericksen B, Lu WY, Lehrer RI, Lu W (2009). Through the looking glass, mechanistic insights from enantiomeric human defensins. J Biol Chem 284(42):29180-92.


74. Miles K, Clarke DJ, Lu W, Sibinska Z, Beaumont PE, Davidson DJ, Barr TA, Campopiano DJ, Gray M (2009). Dying and necrotic neutrophils are anti-inflammatory secondary to the release of alpha-defensins. J Immunol 183(3):2122-32.


73. de Leeuw E, Rajabi M, Zou G, Pazgier M, Lu W (2009). Selective arginines are important for the antibacterial activity and host cell interaction of human alpha-defensin 5. FEBS Lett 583(15):2507-12.


72. Lehrer RI, Jung G, Ruchala P, Wang W, Micewicz ED, Waring AJ, Gillespie EJ, Bradley KA, Ratner AJ, Rest RF, Lu W (2009). Human alpha-defensins inhibit hemolysis mediated by cholesterol-dependent cytolysins. Infect Immun 77(9):4028-40.


71. Lehrer RI, Jung G, Ruchala P, Andre S, Gabius HJ, Lu W (2009). Multivalent binding of carbohydrates by the human alpha-defensin, HD5. J Immunol 183(1):480-90.


70. Pazgier M, Liu M, Zou G, Yuan W, Li C, Li C, Li J, Monbo J, Zella D, Tarasov SG, Lu W (2009). Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX. Proc Natl Acad Sci USA 106(12):4665-70.


69. Gryllos I, Tran-Winkler HJ, Cheng MF, Chung H, Bolcome R 3rd, Lu W, Lehrer RI, Wessels MR (2008). Induction of group A Streptococcus virulence by a human antimicrobial peptide. Proc Natl Acad Sci USA 105(43):16755-60.


68. Wang S, Han J, Wang Y, Lu W, Chi C (2008). Design of peptide inhibitors for furin based on the C-terminal fragment of histone H1.2. Acta Biochim Biophys Sin 40(10):848-54.


67. Li C, Liu M, Monbo J, Zou G, Li C, Yuan W, Zella D, Lu WY, Lu W (2008). Turning a scorpion toxin into an antitumor miniprotein. J Am Chem Soc 130(41):13546-8.

(Selected by Faculty of 1000 Biology as a Must Read Paper and highlighted by ChemBioChem


66. Zou G, de Leeuw E, Lubkowski J, Lu W (2008). Molecular determinants for the interaction of human neutrophil alpha defensin 1 with its propeptide. J Mol Biol 381(5):1281-91.


65. Li C, Wu Z, Liu M, Pazgier M, Lu W (2008). Chemically synthesized human survivin does not inhibit caspase-3. Protein Sci 17(9):1624-9.


64. Rajabi M, de Leeuw E, Pazgier M, Li J, Lubkowski J, Lu W (2008). The conserved salt bridge in human alpha-defensin 5 is required for its precursor processing and proteolytic stability. J Biol Chem 283(31):21509-18.

(Selected as a Paper of the Week by the JBC Editorial Board


63. Klotman ME, Rapista A, Teleshova N, Micsenyi A, Jarvis GA, Lu W, Porter E, Chang TL (2008). Neisseria gonorrhoeae-induced human defensins 5 and 6 increase HIV infectivity: role in enhanced transmission. J Immunol 180(9):6176-85.