Post-Doctoral UCLA 1967; Ph.D. University of California at Berkeley 1965; B.S. Loras College 1961
Research in our laboratory is focused on a study of the solution reactions of epoxides, with the goal of better understanding the detailed mechanisms of their hydrolysis reactions and reactions with acidic and nucleophilic reagents. This interest is stimulated by the observation that polycyclic aromatic hydrocarbons, which are widely spread environmental pollutants, are often metabolized to epoxide derivatives. Certain polycyclic aromatic hydrocarbons are highly carcinogenic, and this biological effect is attributed to their metabolism to reactive epoxide intermediates that react with DNA and other cellular macromolecules. Our studies of the reactions of diol epoxide metabolites of polycyclic aromatic hydrocarbons and of model epoxide systems are designed to provide us with a better understanding of their reactions in biological systems.