Post-Doctoral Pennsylvania State University 2011; Ph.D. University of Minnesota - Twin Cities 2005; B.S. Yonsei University, Seoul, Korea 1997
Purinosome (red) and microtubule (green) in live HeLa cells
Cellular Biochemistry of Metabolic Multienzyme Complexes in Living Cells:
The broad objective of my laboratory is to contribute to our understanding of how sequential metabolic enzymes are organized in living cells and how such metabolic organizations are spatially and/or temporarily regulated in response to cellular signals relevant to human diseases; including but not limited to cancer, diabetes and obesity.
Since the concept of the “metabolon” was conceived in 1970s, the discovery of the “purinosome”, a reversible metabolic macromolecular complex in human cells [S.An et al. Science (2008) 320, 103], stands as the first examples of transient metabolons in live cells and thus sets the stage for an extraordinary opportunity to explore the spatial and temporal advantages to the cell in assembling and disassembling this cluster of proteins. Indeed, my laboratory is highly motivated to further explore the purinosome and other cellular metabolons as the heart of human disease mechanisms. Collectively, the research projects in my laboratory have potentials to invoke a paradigm shift in our thinking about the operation of cellular biosynthetic pathways, and outcomes will be beneficial for human health.
To learn more about the lab, please click the link: http://sites.google.com/a/umbc.edu/songonan/