Ph.D. Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 1991; Post-Doctoral Johns Hopkins University 1994; Post-Doctoral Massachusetts Institute of Technology (MIT) 1997
1. Li, H. G., Guan, Y., Szczepanska, A., Moreno-Vargas, A. J., Carmona, A. T., Robina, I., Lewis, G. K., Wang, L. X., “Synthesis and anti-HIV activity of trivalent CD4-mimetic miniproteins”, Bioorganic & Medicinal Chemistry, 15, 4220-4228 (2007).
2. Li, X., Wang, L. X., Wang, X., Roseman, S., “The chitin catabolic cascade in the marine bacterium Vibrio Cholerae: Characterization of a unique chitin oligosaccharide deacetylase”, Glycobiology, 17, 1377-1387 (2007).
3. Wang, J., Li, H., Zou, G., Wang, L. X., “Novel template-assembled oligosaccharide clusters as epitope mimics for HIV-neutralizing antibody 2G12. Design, synthesis, and antibody binding study”, Organic & Biomolecular Chemistry, 5, 1529-1540 (2007). (This paper was featured as the front cover of the journal: Organic & Biomolecular Chemistry, Vol. 5, Issue 10, 2007; the work was also highlighted in Chemical Biology (RSC), 2007, 2, B44).
4. Wang, L. X., “Toward oligosaccharide- and glycopeptide-based HIV vaccines”. Current Opinion in Drug Discovery and Development, 9, 194-206 (2006).
5. Li, B., Song, H., Hauser, S., Wang, L. X. “A highly efficient chemoenzymatic approach toward glycoprotein synthesis”, Organic Letters, 8, 3081-3084 (2006). (This paper was featured in the cover story in Chemical & Engineering News, September 4, 2006)
6. Ni. J., Song, H., Wang, Y., Stamatos, N., Wang, L. X. “Toward a carbohydrate-based HIV-1 vaccine: Synthesis and immunological studies of oligomannose-containing glycoconjugates”. Bioconjugate Chemistry, 17, 493-500 (2006).
7. Zeng, Y., Wang, J., Li, B., Hauser, S., Li, H., Wang, L. X. “Glycopeptide synthesis through endoglycosidase-catalyzed oligosaccharide transfer of sugar oxazolines. Probing substrate structural requirement. Chemistry: A European Journal, 12, 3355-3364 (2006).
8. Li, H, Li, B., Song, H., Breydo, L.,Baskakov, I. V., Wang, L. X. “Chemoenzymatic synthesis of HIV-1 V3 domain glycopeptides carrying two N-Glycans and effects of glycosylation on the peptide’s domain”. Journal of Organic Chemistry, 70, 9990-9996 (2005).
9. Li, B., Zeng, Y., Hauser, S., Song, H., Wang, L. X. “Highly efficient endoglycosidase-catalyzed synthesis of glycopeptides using oligosaccharide oxazolines as donor substrates”. Journal of the American Chemical Society, 127, 9692-9693 (2005). (This paper was highlighted in Nature Chemical Biology, 2005, 1(3), August 2005).
10. Wang, J., Le, N., Heredia, A., Song, H., Redfield, R., Wang, L. X. “Modification and structure-activity relationship of a small molecule HIV-1 inhibitor targeting the viral envelope glycoprotein gp120”. Organic & Biomolecular Chemistry, 3, 1781-1786 (2005).
11. Stamatos, N. M., Liang, F., Nan, X., Landry, K., Cross, A. S., Wang, L. X. & Pshezhetsky, A. V. “Endogeneous sialidase activity of human monocytes is up-regulated during cellular differentiation into macrophages”. FEBS Journal, 272, 2545-2556 (2005).
12. Wang, L. X., Song, H., Liu, S., Lu, H., Jiang, S., Ni, J., Li, H. “Chemoenzymatic synthesis of HIV-1 glycopeptides. Effects of glycosylation on the antiviral activity and a-helix bundle-forming ability of gp41 peptide C34”. ChemBioChem, 6, 1068-1074(2005).
13. Hauser, S., Song, H., Li, H., Wang, L. X. “A novel fluorescence-based assay for the transglycosylation activity of endo-beta-N-acetyl-glucosaminidases”. Biochemical & Biophysical Research Communications, 328, 580-585 (2005).
14. Li, H., Singh, S., Song, H., Zeng, Y., Wang, L. X. “Chemoenzymatic synthesis of CD52 glycoprotein carrying native N-glycans”. Bioorganic and Medicinal Chemistry Letters, 15, 895-898(2005).
15. Wang, L. X., Heredia, A., Song, H., Zhang, Z., Yu, B., Davis, C. & Redfield, R. “Resveratrol glucuronides as the metabolites of resveratrol in humans: characterization, synthesis, and anti-HIV activities”. Journal of Pharmaceutical Sciences, 93, 2448-2457 (2004).
16. Li, H., Song, H., Heredia, A., Le, N., Redfield, R., Lewis, G. K., & Wang, L. X. “Synthetic bivalent CD4-mimetic miniproteins show enhanced anti-HIV activity over the monovalent miniprotein”. Bioconjugate Chemistry, 15, 783-789 (2004).
17. Ni, J., Powell, R., Baskakov, I. V., DeVico, A., Lewis, G. K. & Wang, L. X. “Synthesis, conformation, and immunogenicity of monosaccharide-centered multivalent HIV-1 gp41 peptides containing the sequence of DP178”. Bioorganic & Medicinal Chemistry, 12, 3141-3148 (2004).
18. Naicker, K. P., Li, H., Heredia, A., Song, H., & Wang, L. X. Design and synthesis of alpha-Gal-conjugated peptide T20 as novel antiviral agent for HIV-immunotargeting. Organic & Biomolecular Chemistry, 2, 660-664 (2004).(This paper was featured as “hot paper” in Chemical Science,, 2004, 1, C26)
19. Wang, L. X., Ni, J., Singh, S. & Li, H. “Binding of high-mannose type oligosaccharides and synthetic oligomannose clusters to human antibody 2G12. Implications for HIV-1 vaccine design”. Chemistry & Biology, 11, 127-134 (2004).
20. Li, H. & Wang, L. X. “Design and synthesis of a cholic acid-based oligomannose cluster as the epitope mimic for human HIV-neutralizing antibody 2G12”. Organic & Biomolecular Chemistry, 2, 483-488 (2004). (This paper was featured as “hot paper” in Chemical Science,, 2004, 1, C20)
21. Naicker, K. P., Jiang, S., Lu, H., Ni, J., Boyer-Chatenet, L., Wang, L. X. & Debnath, A. K. “Synthesis and anti-HIV-1 activity of 4-[4-(4,6-bisphenylamino-[1,3,5]triazin-2-ylamino)-5-methoxy-2-methylphenylazo]-5-hydroxynaphthalene-2,7-disulfonic acid and its derivatives”. Bioorganic & Medicinal Chemistry, 12, 1215-1220 (2004).
22. Locke, D, Bevans, C., Wang, L. X., Zhang, Y., Harris, A. & Lee, Y. C. “Neutral, acidic and basic amide derivatives of anthranilamide for labeling of reducing oligosaccharides”. Carbohydrate Research, 339, 221-231 (2004).
23. Snaar-Jagalska B. E., Krens, S. F., Robina, I., Wang, L. X. & Spaink, H. P. “Specific activation of ERK pathways by chitin oligosaccharides in embryonic zebrafish cell lines”. Glycobiology, 13, 725-32 (2003).
24. Li, H. & Wang, L. X. “Cholic acid as template for multivalent peptide assembly”. Organic & Biomolecular Chemistry, 1, 3507-13 (2003).
25. Wang, L. X. “Bioorganic approaches towards HIV vaccine design” (Invited review). Current Pharmaceutical Design, 9, 1771-1787 (2003).
26. Cross, A. S., Sakarya, S., Rifat, S., Held, T. K., Drysdale, B. E., Grange, P. A., Cassels, F. J., Wang, L. X., Stamatos, N. M., Farese, A., Casey, D., Powell, J., Bhattacharjee, A. K., Kleinberg, M. & Goldblum, S. E. “Recruitment of murine neutrophils in vivo through endogenous sialidase activity”. Journal of Biological Chemistry, 278, 4112-20 (2003).
27. Ni, J., Singh, S. & Wang, L. X. “Synthesis of maleimide-activated carbohydrates as chemoselective tags for site-specific glycosylation of peptides and proteins”. Bioconjugate Chemistry, 14, 232-38 (2003).
28. Singh, S., Ni, J. & Wang, L. X. “Chemoenzymatic synthesis of high-mannose type HIV-1 gp120 glycopeptides”. Bioorganic & Medicinal Chemistry Letters, 13, 327-30 (2003).
29. Wang, L. X., Ni, J. & Singh, S. “Carbohydrate-centered maleimide cluster as new types of templates for multivalent peptide assembling: Synthesis of multivalent HIV-1 gp41 peptides”. Bioorganic & Medicinal Chemistry, 11, 129-36 (2003).
30. Park, J. K., Wang, L. X., Patel, H. V. & Roseman, S. “Molecular cloning and characterization of a unique beta -glucosidase from vibrio cholerae”. Journal of Biological Chemistry, 277, 29555-60 (2002).
31. Park, J. K., Wang, L. X. & Roseman, S. “Isolation of a glucosamine-specific kinase, a unique enzyme of Vibrio cholerae”. Journal of Biological Chemistry, 277, 15573-78. (2002).
32. Southwick, A. M., Wang, L. X., Long, S. R. & Lee, Y. C. “Activity of Sinorhizobium meliloti NodAB and NodH enzymes on thiochitooligosaccharides”. Journal of Bacteriology, 184, 4039-43. (2002).