Ph.D. University of South Florida, Tampa 1978; M.S. University of South Florida 1976; Post-Doctoral University of Illinois at Urbana-Champaign 1979
SELECTED PUBLICATIONS
R. S. Hosmane and J. F. Liebman, Paradoxes and paradigms: why is quinoline less basic than pyridine or isoquinoline? A classical organic chemical perspective, “ Struct. Chem.2009, 20, 693-697.
R. S. Hosmane, “Ring-expanded (“fat”) purines and their nucleoside/nucleotide analogues as broad-spectrum therapeutics,” Prog. Heterocycl. Chem. 2009, 21, 35-68.
R. Kumar, R. K. Ujjinamatada, and R. S. Hosmane, 'The first synthesis of a novel 5:7:5-fused diimidazodiazepine ring system and some of its chemical properties, Org. Lett. 2008, 10, 4681-4684.
V. S. R. K. Yedavalli, N. Zhang, P. Zhang, H. Cai, M. F. Starost, R. S. Hosmane, and K-T. Jeang, 'Ring-expanded nucleoside (REN) analogues inhibit RNA helicase and intracellular HIV-1 replication,' J. Med. Chem. 2008, 51, 5043-5051.
R. K. Ujjinamatada, P. Phatak, A. M. Burger, and R. S. Hosmane, “Inhibition of adenosine deaminase by analogues of adenosine and inosine incorporating a common heterocyclic base, 4(7)-amino-6(5)H-imidazo[4,5-d]pyridazin-7(4)one,” J. Med. Chem.2008, 51, 694-698.
P. Zhang, N. Zhang, V. Buckwold, R. S. Hosmane, “Chemical and biological effects of substitution of the 2-position of ring-expanded (“fat”) nucleosides containing the imidazo[4,5-e][1,3] diazepine-4,8-dione ring system: The role of electronic and steric factors on glycosidic bond stability and anti-HCV activity,” Bioorg. Med. Chem., 2007, 15, 4933-4945.
R. K. Ujjinamatada, A. Baier, P. Borowski, and R. S. Hosmane, 'An analogue of AICAR with dual inhibitory activity against WNV and HCV NTPase/helicase: Synthesis and in vitro screening of 4-carbamoyl-5- (4,6-diamino-2,5-dihydro-1,3,5-triazin-2-yl)imidazole-1-ß-D-ribofuranoside,' Bioorg. Med. Chem. Lett. 2007, 17, 2285-2288.
P. Zhang, N. Zhang, B. E. Korba, and R. S. Hosmane, “Structure-activity relationship studies on anti-HCV activity of ring-expanded (‘fat’) nucleobase analogues containing the imidazo[4,5-e][1,3]diazepine-4,8-dione ring system,” Bioorg. Med. Chem. Lett.2007, 17, 2225-2228.
R. K. Ujjinamatada, A. Bhan, and R. S. Hosmane, 'Design of Inhibitors Against Guanase: Synthesis and Biochemical Evaluation of Analogues of Azepinomycin,' Bioorg. Med. Chem. Lett.2006, 16, 5551-5554.
Ravi K. Ujjinamatada, Robin L. Paulman, Roger G. Ptak, and Ramachandra S. Hosmane, “Nucleosides with Self-Complementary Hydrogen-Bonding Motifs: Synthesis and Base-Pairing Studies of Two Nucleosides Containing the Imidazo[4,5-d]pyridazine Ring System” Bioorg. Med. Chem.2006, 14, 6359-6367.
P. Zhang, N. Zhang, B. E. Korba, and R. S. Hosmane, “Synthesis and In Vitro Anti-Hepatitis B and C Virus Activities of Ring-Expanded ('Fat') Nucleobase Analogues Containing the Imidazo[4,5-e][1,3]diazepine-4,8-dione Ring System,” Bioorg. Med. Chem. Lett.2005, 15, 5397-5401.
R. K. Ujjinamatada and R. S. Hosmane, “Selective Functional Group Transformation Using Guanidine: The Conversion of an Ester Group into an Amide in Vinylogous Ester-Aldehydes,” Tetrahedron Lett.2005, 46, 6005-6009.
R. K. Ujjinamatada, Y. S. Agasimundin, P. Zhang, V. Koch,H. Schmitz, P. Borowski, K. Kalicharran, A. Fattom,and R. S. Hosmane, “A Novel Imidazole Nucleoside Containing a Diaminodihydro-s-Triazine as a Substituent and an Inhibitory Activity against the West Nile Virus NTPase/Helicase,” Nucleosides Nucleotides Nucleic Acids 2005, 24, 1775-1788.
R. K. Ujjinamatada, Y. S. Agasimundin, Y. S., P. Borowski, and R. S. Hosmane, “ Reactions of Guanidine with Vinylogous Ester-Aldehydes: Synthesis and Anti-West Nile Virus Activity of a Novel Imidazole Nucleoside Containing a Diaminodihydro-s-triazine as a Substituent,” Antiviral Res. 2005, 65, A68-A69.
T. A. Roach, V. W. Macdonald, and R. S. Hosmane, “A Novel Site-Directed Affinity Reagent for Cross-Linking Human Hemoglobin: Bis[2-(4-phosphonooxy phenoxy)carbonylethyl]phosphinic Acid (BPPCEP)” J. Med. Chem.2004, 47, 5847-5859.
A. Reayi and R. S. Hosmane, “Inhibition of Adenosine Deaminase by Novel 5:7-Fused Heterocycles Containing the Imidazo[4,5-e][1,2,4]triazepine Ring System: A Structure-Activity Relationship Study,” J. Med. Chem. 2004, 47, 1044-1050.
A. Reayi and R. S. Hosmane, 'Inhibitors of Adenosine Deaminase: Continued Studies of Structure-Activity Relationships in Analogues of Coformycin,' Nucleosides Nucleotides Nucleic Acids 2004, 23, 263-270.
R. S. Hosmane and J. F. Liebman, “Resonance Stabilization in Diazophenoxides,” Struct. Chem.2004, 15, 253-255.
R. S. Hosmane, “Antiviral Agents,” in Kirk-Othmer Encyclopedia of Chemical Technology, John Wiley & Sons, New York, 2004, Vol. 3, pp 135-182 (invited article).
S. Gunther, M. Asper, C. Röser, L. K. S. Luna, C. Drosten, B. Becker-Ziaja, P. Borowski, H. –M. Chen, and R. S. Hosmane, “Application of Real-Time PCR for Testing Antiviral Compounds Against Lassa Virus, SARS Corona Virus, and Ebola Virus In Vitro,” Antiviral Res.2004, 63, 209-215.
N. Zhang, H.-M. Chen, V. Koch, H. Schmitz, C.-L. Liao, M. Bretner, V. S. Bhadti, A. I. Fattom, R. B. Naso, R. S. Hosmane, and P. Borowski, 'Ring-Expanded Nucleoside and Nucleotide (REN) Analogues Exhibit Potent In Vitro Activity Against Flaviviridae NTPases/Helicases, including Those of the West Nile Virus (WNV), Hepatitis C Virus (HCV), and Japanese Encephalitis Virus (JEV),' J. Med. Chem. 2003, 46, 4149-4164.
N. Zhang, H.-M. Chen, V. Koch, H. Schmitz, C.-L. Liao, A. I. Fattom, R. B. Naso, K. Kalicharran, P. Borowski, and R. S. Hosmane, 'Potent inhibition of NTPase/helicase of the West Nile Virus by Ring-Expanded Nucleoside (REN) Analogues,' J. Med. Chem. 2003, 46, 4776 - 4789.
P. Borowski, M. Lang, A. Haag, H. Schmitz, J. Choe, H. ‑M. Chen, and R. S. Hosmane, “Characterization of Imidazo[4,5‑d]pyridazine Nucleosides as Modulators of Unwinding Reaction Mediated by West Nile Virus NTPase/Helicase: Evidence for Activity on the Level of Substrate and/or Enzyme,” Antimicrob. Agents Chemotherap., 2002, 46, 1231-1239.
R. K. Sood, V. S. Bhadti, A. I. Fattom, R. B. Naso, H. Chen, B. E. Korba, E. Kern, and R. S. Hosmane, 'Novel Ring-Expanded Nucleoside Analogs Exhibit Potent and Selective Inhibition of Hepatitis B Virus Replication in Cultured Human Hepatoblastoma Cells,' Antiviral Res.2002, 53, 159-164.
F. N. Burnett and R. S. Hosmane, 'Synthesis of a Novel Ring-Expanded Purine Analogue Containing a 5:8-Fused Imidazo[4,5-e][1,2,4]triazocine Ring System Amidst Opportunistic Rearrangements and Ring Transformations,' Tetrahedron 2002, 58, 9567-9578.
N. Zhang, H. -M. Chen, R. Sood, K. Kalicharran, A. I. Fattom, R. B. Naso, D. L. Barnard, R. W. Sidwell, and R. S. Hosmane, 'In Vitro Inhibition of Measles Virus Replication by Novel Ring-Expanded Nucleoside Analogues Containing the Imidazo[4,5-e][1,3]diazepine Ring System,” Bioorg. Med. Chem. Lett.2002, 12, 3391-3394.
R. Hosmane, 'Ring-Expanded ('Fat') Nucleosides as Broad-Spectrum Anticancer and Antiviral Agents,' in 'Current Topics in Medicinal Chemistry: Recent Developments in Antiviral Nucleosides, Nucleotides, and Oligonucleotides,' Hosmane, R. S., Ed., Bentham Science Publishers, 2002, Vol. 2, pp. 1093-1109 (invited article).
R. Hosmane, 'Coformycin and Analogues as Inhibitors of Adenosine Deaminase,' in 'Modified Nucleosides, Synthesis, and Applications,' Loakes, D, Ed., Transworld Research Network, Trivendrum, 2002; pp.133-151 (invited article).
P. Borowski, A. Niebuhr, H. Schmitz, R. S. Hosmane, M. Bretner, M. A. Siwecka, and T. Kulikowski, 'NTPase/Helicase of Flaviviridae: Inhibitors and Inhibition of the Enzyme,' Acta Biochem. Polon.2002, 49, 597-614.
M. V. Roux, M. Temprado, J. Z. Dávalos, P. Jiménez, R. S. Hosmane, and J. F. Liebman, 'Enthalpy of Formation of Methyl Benzoate: Calorimetry and Consequences,' Phys. Chem. Chem. Phys.2002, 4, 3611-3613.
R. S. Hosmane and J. F. Liebman, 'Diazomethane and Ethyl Diazoacetate: The Role of Substituent Effects on Stability,' Struct. Chem. 2002, 5-6, 501-503.
