Chem-Biochem Home | UMBC Home | Directory | Apply (Free!) | Administrative Resources | myChem | Search 
CONTACT INFORMATION
Office: MEYR 475D
Phone: 410-455-2512
Professional Interests
Publications
Honors/Awards
Funding
Meeting/Events
Courses Taught
Research Group
Elsa Garcin
Assistant Professor
Post-Doctoral The Scripps Research Institute, La Jolla (CA) 1999; Ph.D. Universite Joseph Fourier, Grenoble (France) 1998; M.S. Universite Joseph Fourier, Grenoble (France) 1994
SELECTED PUBLICATIONS

Visit the Garcin Lab Homepage:

Seeger F, Quintyn R, Tanimoto A, Williams GJ, Tainer JA, Wysocki VH, Garcin ED. “Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity” Biochemistry [epub ahead online] March 14 2014.

Rogers NM, Seeger F, Garcin ED, Roberts DD, Isenberg JS. “Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow” Frontiers in Physiology 5(134), [epub ahead online] March 18 2014.

Purohit R, Fritz BG, The J, Issaian A, Weichsel A, David CL, Campbell EV, Hausrath AC, Rassouli-Taylor L, Garcin ED, Gage MJ, and Montfort WR. 'YC-1 binding to the beta subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the alpha subunit'. Biochemistry  53(1), (2014), 101-114. PMC3914721

 

Guan ZW, Haque MM, Wei CC, Garcin ED, Getzoff ED, Stuehr DJ “Lys842 in neuronal nitric-oxide synthase enables the autoinhibitory insert to antagonize calmodulin binding, increase FMN shielding, and suppress interflavin electron transfer” J. Biol. Chem. 285 (5), (2010), 3064-3075. PMC2823414

Elsa Garcin, 'La clé vers de nouveaux inhibiteurs (A novel strategy to design iNOS specific inhibitors)' Médecines Sciences, 25 (2009), 562-564.

Nature Research Highlights

Garcin E.D., Arvai, A.S., Rosenfeld R.J., Kroeger, M.D., Crane, B.R., Andersson G., Andrews A., Hamley P.J., Mallinder P.R., Nicholls D.J., St-Gallay S.A., Tinker A.C., Gensmantel N.P., Mete A., Cheshire D.R., Connolly S., Stuehr D.J., Aberg A., Wallace A.V., Tainer J.A., Getzoff E.D. 'Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.' Nat. Chem. Biol. 4 (2008), 700-707. Published online: 12 October 2008; |doi:10.1038/nchembio.115

Garcin E.D., Hosfield D.J., Haas B.J.,Björas M., Cunningham R., Tainer J.A. 'DNA apurinic/apyrimidinic site binding and excision by endonuclease IV' Nat. Struct. Mol. Biol. 15 (5), (2008), 515-522.

Rameau G.A., Tukey D.S., Garcin-Hosfield E.D., Misra C., Titcombe R.F., Khatri L., Getzoff E.D., Ziff E.B. 'Biphasic coupling of neuronal nitric oxide synthase phosphorylation to the NMDA receptor induces AMPA receptor trafficking and neuronal cell death.' J. Neurosciences 27 (13), 3445-3455 (2007)

Panda K., Haque M.M., Garcin-Hosfield E.D., Durra D., Getzoff E.D., Stuehr D.J. 'Surface charge interactions of electron transport modules govern catalysis by nitric oxide synthase.' J. Biol. Chem. 281(48), 36819-36827 (2006).

Tiso M, Konas DW, Panda K, Garcin ED, Sharma M, Getzoff ED, Stuehr DJ. 'C-terminal tail residue Arg1400 enables NADPH to regulate electron transfer in neuronal nitric oxide synthase.' J. Biol. Chem. 280(47), 39208-39219 (2005).

Garcin E.D., Bruns C.M., Lloyd S.J., Hosfield D.J., Tiso M., Gachhui R., Stuehr D., Tainer J.A. and Getzoff E.D. 'Structural Basis for isozyme-specific regulation of electron transfer in Nitric Oxide Synthase.' J. Biol. Chem. 279(36), 37918-27 (2004).

Rosenfeld R.J., Garcin E.D., Panda K., Andersson G., Aberg A., Wallace A.V., Morris G.M., Olson A.J., Stuehr D.J., Tainer J.A. and Getzoff E.D. 'Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency. 'Biochemistry 41 (47), 13915-13925 (2002).

E. Garcin, X. Vernede, C. Hatchikian, A. Volbeda, M. Frey, J.-C. Fontecilla-Camps 'The Crystal Structure of a reduced [NiFeSe] hydrogenase provides an image of the activated catalytic center.' Structure 7(5), 557-566 (1999).