Chem-Biochem Home | UMBC Home | Directory | Apply (Free!) | Administrative Resources | myChem | Search 

CONTACT INFORMATION
MEYR 408
Phone: 410-455-1412
MEYR 411
Phone: 410-455-1412

Research Description
Current Members
Past Members
Projects
Multifunctional Nanovectors for Chemotherapy
Lisinopril-Capped Gold Nanoparticles for Targeted CT Imaging of Tissue ACE
Daniel Group
Lisinopril-Capped Gold Nanoparticles for Targeted CT Imaging of Tissue ACE
Lisinopril-Capped Gold Nanoparticles for Targeted CT Imaging of Tissue ACE
The development of cardiac and pulmonary fibrosis have been associated with overexpression of angiotensin-converting enzyme (ACE). Thus, targeted imaging of the ACE is of crucial importance for monitoring of the tissue ACE activity as well as the treatment efficacy in heart failure.  In this respect, lisinopril-capped gold nanoparticles were prepared to provide a new type of probe for targeted molecular imaging of ACE by tuned K-edge computed tomography (CT) imaging.  Concentrated solutions of these modified gold nanoparticles, with a diameter of around 16 nm, show high contrast in CT imaging and have been used for in vivo testing on rats.