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CONTACT INFORMATION
MEYR 408
Phone: 410-455-1412
MEYR 411
Phone: 410-455-1412

Research Description
Current Members
Past Members
Projects
Multifunctional Nanovectors for Chemotherapy
Lisinopril-Capped Gold Nanoparticles for Targeted CT Imaging of Tissue ACE
Daniel Group
Gold Nanoparticle-cored PPI dendrimers as platform for multifunctional drug delivery systems.
Gold Nanoparticle-cored PPI dendrimers as platform for multifunctional drug delivery systems.
Multifunctional Nanovectors for Chemotherapy
The objective of this project is the preparation and testing of a multifunctional drug delivery system based on gold nanoparticles and functionalized dendrons (Scheme ), for use in  cancer chemotherapy. The functionalized dendrons to be constructed will contain the therapeutic agents  (dendrons D and E), a targeting moiety (dendron T) for preferential uptake by tumor cells. At the moment, the group is focusing on pancreatic and prostate cancer.
The in vitro testing will be conducted in collaboration with the Greenebaum Cancer Center Translational Laboratory at the University of Maryland School of Medicine (UMSOM). The targeting properties of the nanovectors will be fisrt evaluated. Antiproliferative activity/cytotoxicity of the nanovectors will be assessed by using the methyltetrazolium (MTT) proliferation assay. Inhibitory concentrations 50 and 100% will be determined.