The Wang Lab is working in the areas of bioorganic chemistry, synthetic carbohydrate chemistry, glycobiology, and immunology. Current research in the group is centered on protein glycosylation, one of the most ubiquitous posttranslational modifications of proteins in eukaryotes. It is estimated that half of total human proteins are glycoproteins. Glycosylation adds a new level of structural and functional diversity of proteins and expands the biological information of an otherwise concise human genome. Students in Wang group combine synthetic organic chemistry, structural biology, and immunology to understand the functional roles of glycans and glycoproteins in biological system. Current research projects include: 1) Development of new chemoenzymatic methods for the synthesis of oligosaccharides and glycoproteins; 2) Structural and mechanistic study of endoglycosidases and glycosynthases; and 3) HIV glycobiology and vaccine design targeting the viral envelope glycoproteins.