and Genetics seek to understand how the molecules that make
up cells determine the behavior of living things. Biologists
use molecular and genetic tools to study the function of
those molecules in the complex milieu of the living cell.
Groups in our department are using these approaches to study
a wide variety of questions, including the fundamental processes
of transcription and translation, mechanisms of global gene
control including signal transduction pathways, the function
of the visual and olfactory systems, and the nature of genetic
diversity in natural populations and how that affects their
evolution, among others. The systems under study cover the
range of model organisms (bacteria, yeast, slime molds, worms,
fruit flies, zebrafish, and mice) though the results of these
studies relate directly or indirectly to human health.
Molecular genetics of translational accuracy in the yeast Saccharomyces cerevisiae and bacterium Escherichia coli
Molecular phylogenetic systematics; phylogenetic reconstruction of gene families
Genetic, biochemical, and phylogenetic approaches to understanding the synthesis, structure, and function of ribosomes in bacteria and yeast
Identification and characterization of transposons for tagging important developmental loci in Volvox carteri
Mechanism of mammalian ribosomal RNA synthesis and its regulation.
Characterizing function of genes regulating plant innate immunity and dissecting defense signaling networks
Genetic, biochemical, and phylogenetic approaches to understanding the synthesis, structure, and function of ribosomes in bacteria and yeast.
Wolf, Jr., Richard E.
Investigation of a new mechanism of transcription activation in the bacterium E. coli and investigation of a new mechanism of induction.
We study the role of the Wnt signaling pathway in controlling cell fate decisions during C. elegans development. We also study regulation and function of the Hox gene lin-39 in C. elegans.
Molecular microbial ecology, physiology and genetics
My research program uses the techniques of molecular biology to explore structure function relationships of visual pigments.
We use the methods of Molecular Biology and Genetics to identify and study genes involved in cell fate specification and developmental morphogenesis
Genetic mapping of quantitative traits, association mapping to identify the effects of natural polymorphism in candidate genes on phenotypic variation
We are developing new transgenic mouse models of human prostate cancer.
We are investigating the regulation of brain development and metabolism. These studies are expected to contribute to the prevention of neural tube birth defects and the treatment of stroke.
Tumor immunology; molecular and genetic regulation of tumor-induced immunosuppressive cells
We investigate the role of ubiquitin/proteasome mediated protein degradation in transcription and the regulation of gene expression in eukaryotes
Cross-linking between experimental assays and in-silico data for regulatory elements.
We use loss-of-function and gain-of-function genetic strategies in Drosophila to identify new genes involved in cell migration, and to better understand molecular pathways required for cell movement.
Studying bacterial physiology using systems and synthetic biology; Determining how microbes sense the environment and obtain energy examining the mechanisms of plant cell wall degradation in bacteria