Olesya Chornoguz, a PhD student in the Ostrand-Rosenberg lab was invited to give a short talk to the Annual American Association of Cancer Research meeting held in San Diego, California, April 11-16, 2008.   Ms. Chornoguz was also awarded a travel grant to attend the meeting.

Work in the laboratory of Dr. Suzanne Ostrand-Rosenberg, Robert and Jane Meyerhoff Chair of Biochemistry, was profiled in a recent issue of Science magazine. The article discussed the increased numbers of myeloid derived suppressor cells (MDSCs) in cancer patients and the fact that they interfere with immunotherapy as a cancer treatment. In a series of recent papers, Dr. Rosenberg's laboratory has detailed how inflammation stimulates production of MDSCs and that the cells themselves promote inflammation.

The profiled research was a collaboration between Dr. Rosenberg, Dr. Pratima Sinha (Asst. Research Scientist), Dr. Stephanie Bunt (recent PhD graduate in Biological Sciences), Ms. Virginia Clements (technician) and Dr. Jeff Leips (Associate Professor) among others.

Profile: Marx J. Cancer immunology. Cancer's bulwark against immune attack: MDS cells. Science. 2008 319:154-156 [PDF]

Lab publications cited:
Bunt SK, Yang L, Sinha P, Clements VK, Leips J, Ostrand-Rosenberg S. Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression. Cancer Res. 2007 67:10019-10026 [PDF]
Sinha P, Clements VK, Bunt SK, Albelda SM, Ostrand-Rosenberg S. Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response. J Immunol. 2007 179:977-983 [PDF]